Insulin, chemistry, structure, and function of insulin and related hormones : : Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979 / / ed. by Dietrich Brandenburg, Axel Wollmer.
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Table of Contents:
- Frontmatter
- ACKNOWLEDGEMENTS
- Preface
- CONTENTS
- INTRODUCTION
- SECTION I. STRUCTURE OF INSULIN
- A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals
- Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid
- Correlation of Structural Details of Insulin in the Crystal and in Solution
- SECTION II. PEPTIDE SYNTHESIS
- An Assessment of Protecting Group Strategies in Synthesis of Large Peptides
- Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase
- [A14-Phenylalanine-Insulin]: A Synthetic Analogue
- [B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin
- The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin
- A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives
- Alternative Approach for Human Proinsulin Synthesis
- An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments
- SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION
- Progress Towards the Semisynthesis of Preproinsulin
- Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin
- Enzyme-Catalyzed Semisynthesis with Insulin Derivatives
- The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies
- A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin
- Preparation of Covalent Insulin Dimers
- Reactions of Insulin Derivatives with ETAC Reagents
- SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES
- The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin
- Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr
- Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1
- Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium
- Radioactive Labelling (14 C, 3 H) of Insulin and Insulin Derivatives by Reductive Methylation; Isolation of Homogeneous N, N-Di-Methylated Derivatives
- Quantitative Determination of Insulin by Gradient Elution HPLC
- Some Preliminary Findings in Isotachophoretic Analyses of Insulin
- Studies on the Denaturation of Dissolved Insulin
- SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION
- 125 I-SpHPP-Avidin: A Tool for Hormone Receptor Studies
- Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor
- Hydrophobic Interaction Chromatography as a Tool in Insulin Receptor Purification
- Localization of Insulin-Receptor Complexes on the Surface of Whole Cells by Autoradiography
- Insulin Receptors in the Heart Muscle: Evidence for the Negative Cooperativity Binding Model
- Insulin Receptors, Insulin Degradation, and Biological Activity
- Regulation of Insulin Receptors in Isolated Hepatocytes from Normal and Streptozotocin-Diabetic Rats in the Fed and 48 H Fasted State
- Insulin-Receptor Turnover and Down Regulation
- Receptor-Mediated Internalisation of Insulin, Glucagon and Growth Hormone in Intact Rat Liver. A Biochemical Study
- Kinetics of Insulin Binding to Its Receptors in vivo. Effects of Fasting
- Hystricomorph Insulins and Insulin Receptors
- SECTION VI. PHOTO-INDUCED HORMONE-RECEPTOR COUPLING
- Photoreactive Insulin Derivatives: Preparation and Characterization
- Photoreactive Insulin Derivatives: Chemical and Physical Properties
- The Preparation and Application of an A1-Substituted Photo-Reactive Insulin Analogue
- Photoaffinity Labeling of Insulin Receptor Proteins of Liver Plasma Membranes
- Characterisation of Insulin Binding Sites in Rat Liver Plasma Membranes Using Photoreactive Insulin Analogues
- Permanent Activation of Lipogenesis by Insulin Covalently Bound to Adipocyte Receptors
- SECTION VII. STRUCTURE, BINDING, ACTIVITY
- The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding
- Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites
- Properties of a Mutant Insulin Species Causing Human Diabetes
- A1-Modified Insulins: Receptor Binding and Biological Activity
- Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine
- Functional Role of the N-Terminal Region of the B-Chain of Insulin
- Biological Properties of Covalent Insulin Dimers
- Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin
- In vitro and in vivo Effects of Poly-N-Vinylpyrrolidone- Insulin
- Study of Insulin Action by Use of Insulin-Dextran Complex: Uptake of Insulin into Subcellular Fractions and Stimulation of Pyruvate Dehydrogenase in Mouse Adipocytes
- Studies on the Mechanism of Insulin Action VI: The Interaction of Insulin Fragments with Insulin Receptor
- Stimulation of Intracellular H2 02 Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities
- Early Events in Insulin Binding and Insulin Action in Fat Cells and Hepatocytes
- Role of the Biodegradation Process in the Action of Insulin. A Proposal for a Model Consisting of Sulfhydryl- Disulfide Interchange Reaction and Proteolysis
- Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action
- SECTION VIII. DEGRADATION
- Studies on Uptake of [3 H]-Insulin by Erythrocytes
- An Insulin-Degrading Enzyme from Human Erythrocytes: Isolation and Characterization
- Comparison of 125 I-Insulin and [B1- 3 H-Phenylalanine]- Insulin Degradation by Insulin Protease
- The Chemical Characterization of the Products of the Processing of Subcutaneously Injected Insulin
- Some Inhibitors of Insulin Degradation
- Excretion of Endogenous and Exogenous Insulin by Kidney in Diabetic Ketoacidosis
- Incubation of Insulin in Hyperglycemic Blood Generates Insulin Dimers
- SECTION IX. IMMUNOLOGY
- Genetic Regulation of the Immune Response of Mice to Insulins of Different Species
- Genetic Control of the Immune Response to Insulin
- Analysis of the Immunogenicity of Three Insulin- Preparations
- Studies on the Immunological Properties of Natural and Modified Insulins
- Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin
- The Induction of Hyperglycemia with Insulin Antibodies to B-Chain Determinants
- The Pattern of B-Lymphocyte Specificities for Modified and Unmodified Insulins in the Mouse
- Specificity of Rabbit Anti-Insulin Antibody
- Radioimmunoassay of Chemically-Modified Insulins - Use and Misuse
- Purity of Chromatographycally Purified Insulins Measured by Skin-Reactivity and Insulin-Specific IGE
- SECTION X. BIOSYNTHESIS, STORAGE, EVOLUTION
- Human Preproinsulin: Primary Structure of the Messenger RNA
- Quantification of Proinsulin Biosynthesis by Determination of Specific Radioactivity of [3 H]-Leucine in Pancreatic Islets
- Immunoreactive Rat C-Peptides I and II in Glucose Perfusate of Isolated Pancreas
- Biosynthesis of Somatostatin in Pancreatic Islets of Wistar Rats
- Crystallography of Intracellular Insulin and Glucagon as Revealed by Investigations of Tissues and Models
- Pancreatic Hormone Storage Granules: The Role of Metal Ions and Polypeptide Oligomers
- On the Molecular Biology of Hagfish Insulin
- SECTION XI. INSULIN-RELATED HORMONES
- Possible Relationships in the Processing, Storage and Secretion of Some Insulin-Related Peptides
- Insulin-Like Growth Factors
- Relaxin and Relaxin-Like Peptides in Ovaries of Pregnant Sows and Sharks
- Structural Studies on Porcine Relaxins and their Biosynthetic Precursors
- PRESENTATIONS NOT INCLUDED IN THIS VOLUME
- LIST OF PARTICIPANTS
- ABBREVIATIONS
- SUBJECT INDEX
- AUTHOR INDEX
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