Insulin, chemistry, structure, and function of insulin and related hormones : : Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979 / / ed. by Dietrich Brandenburg, Axel Wollmer.
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| Other title: | Frontmatter -- ACKNOWLEDGEMENTS -- Preface -- CONTENTS -- INTRODUCTION -- SECTION I. STRUCTURE OF INSULIN -- A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals -- Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid -- Correlation of Structural Details of Insulin in the Crystal and in Solution -- SECTION II. PEPTIDE SYNTHESIS -- An Assessment of Protecting Group Strategies in Synthesis of Large Peptides -- Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase -- [A14-Phenylalanine-Insulin]: A Synthetic Analogue -- [B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin -- The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin -- A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives -- Alternative Approach for Human Proinsulin Synthesis -- An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments -- SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION -- Progress Towards the Semisynthesis of Preproinsulin -- Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin -- Enzyme-Catalyzed Semisynthesis with Insulin Derivatives -- The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies -- A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin -- Preparation of Covalent Insulin Dimers -- Reactions of Insulin Derivatives with ETAC Reagents -- SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES -- The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin -- Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr -- Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1 -- Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium -- Radioactive Labelling (14 C, 3 H) of Insulin and Insulin Derivatives by Reductive Methylation; Isolation of Homogeneous N, N-Di-Methylated Derivatives -- Quantitative Determination of Insulin by Gradient Elution HPLC -- Some Preliminary Findings in Isotachophoretic Analyses of Insulin -- Studies on the Denaturation of Dissolved Insulin -- SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION -- 125 I-SpHPP-Avidin: A Tool for Hormone Receptor Studies -- Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor -- Hydrophobic Interaction Chromatography as a Tool in Insulin Receptor Purification -- Localization of Insulin-Receptor Complexes on the Surface of Whole Cells by Autoradiography -- Insulin Receptors in the Heart Muscle: Evidence for the Negative Cooperativity Binding Model -- Insulin Receptors, Insulin Degradation, and Biological Activity -- Regulation of Insulin Receptors in Isolated Hepatocytes from Normal and Streptozotocin-Diabetic Rats in the Fed and 48 H Fasted State -- Insulin-Receptor Turnover and Down Regulation -- Receptor-Mediated Internalisation of Insulin, Glucagon and Growth Hormone in Intact Rat Liver. A Biochemical Study -- Kinetics of Insulin Binding to Its Receptors in vivo. Effects of Fasting -- Hystricomorph Insulins and Insulin Receptors -- SECTION VI. PHOTO-INDUCED HORMONE-RECEPTOR COUPLING -- Photoreactive Insulin Derivatives: Preparation and Characterization -- Photoreactive Insulin Derivatives: Chemical and Physical Properties -- The Preparation and Application of an A1-Substituted Photo-Reactive Insulin Analogue -- Photoaffinity Labeling of Insulin Receptor Proteins of Liver Plasma Membranes -- Characterisation of Insulin Binding Sites in Rat Liver Plasma Membranes Using Photoreactive Insulin Analogues -- Permanent Activation of Lipogenesis by Insulin Covalently Bound to Adipocyte Receptors -- SECTION VII. STRUCTURE, BINDING, ACTIVITY -- The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding -- Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites -- Properties of a Mutant Insulin Species Causing Human Diabetes -- A1-Modified Insulins: Receptor Binding and Biological Activity -- Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine -- Functional Role of the N-Terminal Region of the B-Chain of Insulin -- Biological Properties of Covalent Insulin Dimers -- Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin -- In vitro and in vivo Effects of Poly-N-Vinylpyrrolidone- Insulin -- Study of Insulin Action by Use of Insulin-Dextran Complex: Uptake of Insulin into Subcellular Fractions and Stimulation of Pyruvate Dehydrogenase in Mouse Adipocytes -- Studies on the Mechanism of Insulin Action VI: The Interaction of Insulin Fragments with Insulin Receptor -- Stimulation of Intracellular H2 02 Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities -- Early Events in Insulin Binding and Insulin Action in Fat Cells and Hepatocytes -- Role of the Biodegradation Process in the Action of Insulin. A Proposal for a Model Consisting of Sulfhydryl- Disulfide Interchange Reaction and Proteolysis -- Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action -- SECTION VIII. DEGRADATION -- Studies on Uptake of [3 H]-Insulin by Erythrocytes -- An Insulin-Degrading Enzyme from Human Erythrocytes: Isolation and Characterization -- Comparison of 125 I-Insulin and [B1- 3 H-Phenylalanine]- Insulin Degradation by Insulin Protease -- The Chemical Characterization of the Products of the Processing of Subcutaneously Injected Insulin -- Some Inhibitors of Insulin Degradation -- Excretion of Endogenous and Exogenous Insulin by Kidney in Diabetic Ketoacidosis -- Incubation of Insulin in Hyperglycemic Blood Generates Insulin Dimers -- SECTION IX. IMMUNOLOGY -- Genetic Regulation of the Immune Response of Mice to Insulins of Different Species -- Genetic Control of the Immune Response to Insulin -- Analysis of the Immunogenicity of Three Insulin- Preparations -- Studies on the Immunological Properties of Natural and Modified Insulins -- Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin -- The Induction of Hyperglycemia with Insulin Antibodies to B-Chain Determinants -- The Pattern of B-Lymphocyte Specificities for Modified and Unmodified Insulins in the Mouse -- Specificity of Rabbit Anti-Insulin Antibody -- Radioimmunoassay of Chemically-Modified Insulins - Use and Misuse -- Purity of Chromatographycally Purified Insulins Measured by Skin-Reactivity and Insulin-Specific IGE -- SECTION X. BIOSYNTHESIS, STORAGE, EVOLUTION -- Human Preproinsulin: Primary Structure of the Messenger RNA -- Quantification of Proinsulin Biosynthesis by Determination of Specific Radioactivity of [3 H]-Leucine in Pancreatic Islets -- Immunoreactive Rat C-Peptides I and II in Glucose Perfusate of Isolated Pancreas -- Biosynthesis of Somatostatin in Pancreatic Islets of Wistar Rats -- Crystallography of Intracellular Insulin and Glucagon as Revealed by Investigations of Tissues and Models -- Pancreatic Hormone Storage Granules: The Role of Metal Ions and Polypeptide Oligomers -- On the Molecular Biology of Hagfish Insulin -- SECTION XI. INSULIN-RELATED HORMONES -- Possible Relationships in the Processing, Storage and Secretion of Some Insulin-Related Peptides -- Insulin-Like Growth Factors -- Relaxin and Relaxin-Like Peptides in Ovaries of Pregnant Sows and Sharks -- Structural Studies on Porcine Relaxins and their Biosynthetic Precursors -- PRESENTATIONS NOT INCLUDED IN THIS VOLUME -- LIST OF PARTICIPANTS -- ABBREVIATIONS -- SUBJECT INDEX -- AUTHOR INDEX |
|---|---|
| Format: | Mode of access: Internet via World Wide Web. |
| ISBN: | 9783111646190 9783110637861 |
| DOI: | 10.1515/9783111646190 |
| Access: | restricted access |
| Hierarchical level: | Monograph |
| Statement of Responsibility: | ed. by Dietrich Brandenburg, Axel Wollmer. |
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