Insulin, chemistry, structure, and function of insulin and related hormones : : Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979 / / ed. by Dietrich Brandenburg, Axel Wollmer.
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| Superior document: | Title is part of eBook package: De Gruyter DGBA Medicine and Life Sciences - <1990 |
|---|---|
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| HerausgeberIn: | |
| Place / Publishing House: | Berlin ;, Boston : : De Gruyter, , [2019] ©1980 |
| Year of Publication: | 2019 |
| Edition: | Reprint 2019 |
| Language: | English |
| Online Access: | |
| Physical Description: | 1 online resource (752 p.) :; Num. figs. |
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| 035 | |a (DE-B1597)114131 | ||
| 035 | |a (OCoLC)1102793767 | ||
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| 245 | 0 | 0 | |a Insulin, chemistry, structure, and function of insulin and related hormones : |b Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979 / |c ed. by Dietrich Brandenburg, Axel Wollmer. |
| 250 | |a Reprint 2019 | ||
| 264 | 1 | |a Berlin ; |a Boston : |b De Gruyter, |c [2019] | |
| 264 | 4 | |c ©1980 | |
| 300 | |a 1 online resource (752 p.) : |b Num. figs. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 505 | 0 | 0 | |t Frontmatter -- |t ACKNOWLEDGEMENTS -- |t Preface -- |t CONTENTS -- |t INTRODUCTION -- |t SECTION I. STRUCTURE OF INSULIN -- |t A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals -- |t Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid -- |t Correlation of Structural Details of Insulin in the Crystal and in Solution -- |t SECTION II. PEPTIDE SYNTHESIS -- |t An Assessment of Protecting Group Strategies in Synthesis of Large Peptides -- |t Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase -- |t [A14-Phenylalanine-Insulin]: A Synthetic Analogue -- |t [B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin -- |t The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin -- |t A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives -- |t Alternative Approach for Human Proinsulin Synthesis -- |t An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments -- |t SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION -- |t Progress Towards the Semisynthesis of Preproinsulin -- |t Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin -- |t Enzyme-Catalyzed Semisynthesis with Insulin Derivatives -- |t The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies -- |t A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin -- |t Preparation of Covalent Insulin Dimers -- |t Reactions of Insulin Derivatives with ETAC Reagents -- |t SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES -- |t The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin -- |t Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr -- |t Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1 -- |t Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium -- |t Radioactive Labelling (14 C, 3 H) of Insulin and Insulin Derivatives by Reductive Methylation; Isolation of Homogeneous N, N-Di-Methylated Derivatives -- |t Quantitative Determination of Insulin by Gradient Elution HPLC -- |t Some Preliminary Findings in Isotachophoretic Analyses of Insulin -- |t Studies on the Denaturation of Dissolved Insulin -- |t SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION -- |t 125 I-SpHPP-Avidin: A Tool for Hormone Receptor Studies -- |t Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor -- |t Hydrophobic Interaction Chromatography as a Tool in Insulin Receptor Purification -- |t Localization of Insulin-Receptor Complexes on the Surface of Whole Cells by Autoradiography -- |t Insulin Receptors in the Heart Muscle: Evidence for the Negative Cooperativity Binding Model -- |t Insulin Receptors, Insulin Degradation, and Biological Activity -- |t Regulation of Insulin Receptors in Isolated Hepatocytes from Normal and Streptozotocin-Diabetic Rats in the Fed and 48 H Fasted State -- |t Insulin-Receptor Turnover and Down Regulation -- |t Receptor-Mediated Internalisation of Insulin, Glucagon and Growth Hormone in Intact Rat Liver. A Biochemical Study -- |t Kinetics of Insulin Binding to Its Receptors in vivo. Effects of Fasting -- |t Hystricomorph Insulins and Insulin Receptors -- |t SECTION VI. PHOTO-INDUCED HORMONE-RECEPTOR COUPLING -- |t Photoreactive Insulin Derivatives: Preparation and Characterization -- |t Photoreactive Insulin Derivatives: Chemical and Physical Properties -- |t The Preparation and Application of an A1-Substituted Photo-Reactive Insulin Analogue -- |t Photoaffinity Labeling of Insulin Receptor Proteins of Liver Plasma Membranes -- |t Characterisation of Insulin Binding Sites in Rat Liver Plasma Membranes Using Photoreactive Insulin Analogues -- |t Permanent Activation of Lipogenesis by Insulin Covalently Bound to Adipocyte Receptors -- |t SECTION VII. STRUCTURE, BINDING, ACTIVITY -- |t The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding -- |t Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites -- |t Properties of a Mutant Insulin Species Causing Human Diabetes -- |t A1-Modified Insulins: Receptor Binding and Biological Activity -- |t Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine -- |t Functional Role of the N-Terminal Region of the B-Chain of Insulin -- |t Biological Properties of Covalent Insulin Dimers -- |t Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin -- |t In vitro and in vivo Effects of Poly-N-Vinylpyrrolidone- Insulin -- |t Study of Insulin Action by Use of Insulin-Dextran Complex: Uptake of Insulin into Subcellular Fractions and Stimulation of Pyruvate Dehydrogenase in Mouse Adipocytes -- |t Studies on the Mechanism of Insulin Action VI: The Interaction of Insulin Fragments with Insulin Receptor -- |t Stimulation of Intracellular H2 02 Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities -- |t Early Events in Insulin Binding and Insulin Action in Fat Cells and Hepatocytes -- |t Role of the Biodegradation Process in the Action of Insulin. A Proposal for a Model Consisting of Sulfhydryl- Disulfide Interchange Reaction and Proteolysis -- |t Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action -- |t SECTION VIII. DEGRADATION -- |t Studies on Uptake of [3 H]-Insulin by Erythrocytes -- |t An Insulin-Degrading Enzyme from Human Erythrocytes: Isolation and Characterization -- |t Comparison of 125 I-Insulin and [B1- 3 H-Phenylalanine]- Insulin Degradation by Insulin Protease -- |t The Chemical Characterization of the Products of the Processing of Subcutaneously Injected Insulin -- |t Some Inhibitors of Insulin Degradation -- |t Excretion of Endogenous and Exogenous Insulin by Kidney in Diabetic Ketoacidosis -- |t Incubation of Insulin in Hyperglycemic Blood Generates Insulin Dimers -- |t SECTION IX. IMMUNOLOGY -- |t Genetic Regulation of the Immune Response of Mice to Insulins of Different Species -- |t Genetic Control of the Immune Response to Insulin -- |t Analysis of the Immunogenicity of Three Insulin- Preparations -- |t Studies on the Immunological Properties of Natural and Modified Insulins -- |t Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin -- |t The Induction of Hyperglycemia with Insulin Antibodies to B-Chain Determinants -- |t The Pattern of B-Lymphocyte Specificities for Modified and Unmodified Insulins in the Mouse -- |t Specificity of Rabbit Anti-Insulin Antibody -- |t Radioimmunoassay of Chemically-Modified Insulins - Use and Misuse -- |t Purity of Chromatographycally Purified Insulins Measured by Skin-Reactivity and Insulin-Specific IGE -- |t SECTION X. BIOSYNTHESIS, STORAGE, EVOLUTION -- |t Human Preproinsulin: Primary Structure of the Messenger RNA -- |t Quantification of Proinsulin Biosynthesis by Determination of Specific Radioactivity of [3 H]-Leucine in Pancreatic Islets -- |t Immunoreactive Rat C-Peptides I and II in Glucose Perfusate of Isolated Pancreas -- |t Biosynthesis of Somatostatin in Pancreatic Islets of Wistar Rats -- |t Crystallography of Intracellular Insulin and Glucagon as Revealed by Investigations of Tissues and Models -- |t Pancreatic Hormone Storage Granules: The Role of Metal Ions and Polypeptide Oligomers -- |t On the Molecular Biology of Hagfish Insulin -- |t SECTION XI. INSULIN-RELATED HORMONES -- |t Possible Relationships in the Processing, Storage and Secretion of Some Insulin-Related Peptides -- |t Insulin-Like Growth Factors -- |t Relaxin and Relaxin-Like Peptides in Ovaries of Pregnant Sows and Sharks -- |t Structural Studies on Porcine Relaxins and their Biosynthetic Precursors -- |t PRESENTATIONS NOT INCLUDED IN THIS VOLUME -- |t LIST OF PARTICIPANTS -- |t ABBREVIATIONS -- |t SUBJECT INDEX -- |t AUTHOR INDEX |
| 506 | 0 | |a restricted access |u http://purl.org/coar/access_right/c_16ec |f online access with authorization |2 star | |
| 538 | |a Mode of access: Internet via World Wide Web. | ||
| 546 | |a In English. | ||
| 588 | 0 | |a Description based on online resource; title from PDF title page (publisher's Web site, viewed 30. Aug 2021) | |
| 650 | 4 | |a Insulin. | |
| 650 | 7 | |a MEDICAL / General. |2 bisacsh | |
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| 700 | 1 | |a Brandenburg, D., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Brandenburg, Dietrich, |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Brocks, D.G., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Lange, R.H., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Larsen, U.D., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Lawton, R.G., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Lazarus, N.R., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Linde, S., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Little, S.A., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Lu, Z-X., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Magojo, H.E.M., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Mako, M., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Mann, D., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Markese, J., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Markussen, J., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Meienhofer, J., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Mercado, R., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Mercola, D.A., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Meyer, H., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Meyts, P. De, |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Michiels-Place, M., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Momayezi, M., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Moule, M.L., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Muchmore, D.B., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Mäser, E., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Naithani, V.K., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Neubauer, H., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Neubauer, H.P., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Neville, R.W.J., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Niall, H.D., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Nishida, N., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Obermeier, R., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Offord, R.E., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Olefsky, J.M., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Olivié, J, |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Ozaki, J., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a O’Connor, K., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Petersen, K.-G., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Philippe, J., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Pilch, P.F., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Pipkorn, R., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Piron, M., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Pitts, J.E., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Postel-Vinay, M.-C., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Poucher, H., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Qiu, X-D., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Rees, A.R., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Renner, R., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Reynolds,, |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Robinson, H.M., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Rosenthal, A.S., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Sasaki, A., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Saunders, D., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Schlüter, K., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Sipman, W.A., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Velcovsky, H.-G., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
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| 700 | 1 | |a Wollmer, A., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Wollmer, Axel, |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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| 700 | 1 | |a Zhu, D-Y., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Zhu, J-H, |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Ziegler, M., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a Zühlke, H., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a de Graaf, R.A.G., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 700 | 1 | |a von Specht, B.U., |e contributor. |4 ctb |4 https://id.loc.gov/vocabulary/relators/ctb | |
| 773 | 0 | 8 | |i Title is part of eBook package: |d De Gruyter |t DGBA Medicine and Life Sciences - <1990 |z 9783110637861 |o ZDB-23-GML |
| 776 | 0 | |c print |z 9783110081565 | |
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| 856 | 4 | 0 | |u https://www.degruyter.com/isbn/9783111646190 |
| 856 | 4 | 2 | |3 Cover |u https://www.degruyter.com/cover/covers/9783111646190.jpg |
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