Insulin, chemistry, structure, and function of insulin and related hormones : : Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979 / / ed. by Dietrich Brandenburg, Axel Wollmer.

• Superior document: Title is part of eBook package: De Gruyter DGBA Medicine and Life Sciences - <1990
• MitwirkendeR: Andres, R.,; Arquilla, E.R.,; Bachmann, L.,; Bahrami, S.,; Baird, K.L.,; Baldesten, A.,; Baldwin, D.,; Bedarkav, S.,; Behr, W.,; Berger, M.,; Biemond, M.E.F.,; Birr, C.,; Blake, J.T.,; Blundell, T.L.,; Boime, I.,; Bradshaw, R.A.,; Brandenburg, D.,; Brocks, D.G.,; Bryant-Greenwood, G.,; Büllesbach, E.,; Büllesbach, E.E.,; Cannon, M.M.,; Canova-Davis, E.,; Carpenter, F.H.,; Carter-Su, C.,; Casaretto, M.,; Chance, R.,; Csorba, T.R.,; Cutfield, S.,; Czech, M.P.,; Danho, W.,; Davies, J.G.,; Desbuquois, B.,; Diaconescu, C.,; Dodson, E.J.,; Dodson, G.G.,; Drewes, S.E.,; Dron, D.I.,; Duckworth, W.C.,; Easter, B.R.D.,; Eckel, J.,; Emdin, S.O.,; Epand, R.M.,; Ernest, C.,; Falkmer, S.,; Federlin, K.,; Feng, Y-M,; Finn, F.M.,; Fleischhauer, J.,; Folke, M.,; Friesen, H. -J.,; Friesen, H.-J.,; Froesch, E.R.,; Föhles, J.,; Galloway, J.,; Gammeltoft, S.,; Gast, M.,; Gattner, H-G.,; Gattner, H.-G.,; Gattner,,; Geiger, R.,; Geisen, K.,; Giesen, C.,; Given, B.,; Glatter, U.,; Gliemann, J.,; Goeddel, D.V.,; Goodwin, P.,; Gray, A.,; Grunfeld, C.,; Gu, J-L.,; Halban, P.A.,; Hansen, B.,; Haselbacher, G.,; Haën, C. de,; Hepp, K.D.,; Hoare, S.M.,; Hoenjet, E.,; Hofmann, K.,; Horuk, R.,; Hubenstein, A.M.,; Humbel, R.E.,; Häring, H.,; Häring, H.-U.,; Isaacs, N.,; Jahr, H.,; James, R.,; Jansen, F.K.,; John, M.,; Jones, R.H.,; Junger, E.,; Jäger, K.,; Kahn, C.R.,; Ke, L-T.,; Keck, K.,; Kelso, J.M.,; Kemmler, W.,; Keneko, T.,; Kerp, L .,; Kiesel, U.,; King, G.L.,; Kitabohi, A.E.,; Knorr, R.,; Kobayashi, M.,; Kolb, H.J.,; Kolterman, O.G.,; Kristensen, L.Ø..,; Kuehn, L.,; Kung, Y-T.,; Kuzuya, T.,; Kwok, S.,; Lange, R.H.,; Larsen, U.D.,; Lawton, R.G.,; Lazarus, N.R.,; Linde, S.,; Little, S.A.,; Lu, Z-X.,; Magojo, H.E.M.,; Mako, M.,; Mann, D.,; Markese, J.,; Markussen, J.,; Meienhofer, J.,; Mercado, R.,; Mercola, D.A.,; Meyer, H.,; Meyts, P. De,; Michiels-Place, M.,; Momayezi, M.,; Moule, M.L.,; Muchmore, D.B.,; Mäser, E.,; Naithani, V.K.,; Neubauer, H.,; Neubauer, H.P.,; Neville, R.W.J.,; Niall, H.D.,; Nishida, N.,; Obermeier, R.,; Offord, R.E.,; Olefsky, J.M.,; Olivié, J,; Ozaki, J.,; O’Connor, K.,; Petersen, K.-G.,; Philippe, J.,; Pilch, P.F.,; Pipkorn, R.,; Piron, M.,; Pitts, J.E.,; Postel-Vinay, M.-C.,; Poucher, H.,; Qiu, X-D.,; Rees, A.R.,; Regitz, G.,; Reinauer, H.,; Renner, R.,; Reynolds,,; Rinderknecht, E.,; Robinson, H.M.,; Root, M.A.,; Rosenthal, A.S.,; Roth, M.D.,; Rösen, P.,; Sacks, H.S.,; Saekow, M.,; Sakagami, M.,; Sakamoto, Y.,; Sasaki, A.,; Saunders, D.,; Saunders, D.J.,; Schlüter, K.,; Schmidt, S.,; Schroer, J.,; Schröder, D.,; Schwabe, C.,; Schwander, J.,; Schöne, H.H.,; Schüttler, A.,; Semmler, M.,; Sestoft, L.,; Shield, J.,; Siess, E.A.,; Simon, M.,; Sip, C.C.,; Sipman, W.A.,; Smith, D.G.,; Sodoyez, J.C.,; Sodoyez-Goffaux, F.,; Sonne, 0.,; Sonne, O.,; Standl, E.,; Steiner, D.F.,; Stenz, F.B.,; Stone, D.,; Straßburger, W.,; Summ, H.D.,; Sures, I.,; Sönksen, P.H.,; Tager, H.,; Tamai, I.Y.,; Tatnell, M.A.,; Teetz, V.,; Terris, S.,; Thamm, P.,; Thiry-Moris, Y.M.,; Thomas, J.H.,; Thomas, J.W.,; Thurow, H.,; Track, N.S.,; Tschesche, H.,; Tsohesahe, H.,; Uhmann, R.,; Ullrich, A.,; Ungar, M.,; Uschkoreit, J.,; Vallely, D.,; Van Obberghen, E.,; Varandani, P.T.,; Velcovsky, H.-G.,; Vollmer, A.,; Waelbroeok, M.,; Walter, H.,; Wei, W.,; Whittle, M.R.,; Wick, R.,; Willey, K.P.,; Wisher, M.H.,; Wollmer, A.,; Wood, S.P.,; Xu, W-J.,; Yanaihara, C.,; Yanaihara, N.,; Yeung, C. W.-T.,; Yeung, C.W.-T.,; Yip, C.C.,; Yuan, X-W.,; Zahn, E.,; Zahn, H.,; Zapf, J.,; Zhang, X-T.,; Zhu, D-Y.,; Zhu, J-H,; Ziegler, M.,; Zühlke, H.,; de Graaf, R.A.G.,; von Specht, B.U.,
• HerausgeberIn: Brandenburg, Dietrich,; Wollmer, Axel,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2019]; ©1980
• Year of Publication: 2019
• Edition: Reprint 2019
• Language: English
• Physical Description: 1 online resource (752 p.) :; Num. figs.

Table of Contents

Frontmatter -- ACKNOWLEDGEMENTS -- Preface -- CONTENTS -- INTRODUCTION -- SECTION I. STRUCTURE OF INSULIN -- A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals -- Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid -- Correlation of Structural Details of Insulin in the Crystal and in Solution -- SECTION II. PEPTIDE SYNTHESIS -- An Assessment of Protecting Group Strategies in Synthesis of Large Peptides -- Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase -- [A14-Phenylalanine-Insulin]: A Synthetic Analogue -- [B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin -- The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin -- A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives -- Alternative Approach for Human Proinsulin Synthesis -- An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments -- SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION -- Progress Towards the Semisynthesis of Preproinsulin -- Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin -- Enzyme-Catalyzed Semisynthesis with Insulin Derivatives -- The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies -- A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin -- Preparation of Covalent Insulin Dimers -- Reactions of Insulin Derivatives with ETAC Reagents -- SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES -- The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin -- Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr -- Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1 -- Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium -- Radioactive Labelling (14 C, 3 H) of Insulin and Insulin Derivatives by Reductive Methylation; Isolation of Homogeneous N, N-Di-Methylated Derivatives -- Quantitative Determination of Insulin by Gradient Elution HPLC -- Some Preliminary Findings in Isotachophoretic Analyses of Insulin -- Studies on the Denaturation of Dissolved Insulin -- SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION -- 125 I-SpHPP-Avidin: A Tool for Hormone Receptor Studies -- Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor -- Hydrophobic Interaction Chromatography as a Tool in Insulin Receptor Purification -- Localization of Insulin-Receptor Complexes on the Surface of Whole Cells by Autoradiography -- Insulin Receptors in the Heart Muscle: Evidence for the Negative Cooperativity Binding Model -- Insulin Receptors, Insulin Degradation, and Biological Activity -- Regulation of Insulin Receptors in Isolated Hepatocytes from Normal and Streptozotocin-Diabetic Rats in the Fed and 48 H Fasted State -- Insulin-Receptor Turnover and Down Regulation -- Receptor-Mediated Internalisation of Insulin, Glucagon and Growth Hormone in Intact Rat Liver. A Biochemical Study -- Kinetics of Insulin Binding to Its Receptors in vivo. Effects of Fasting -- Hystricomorph Insulins and Insulin Receptors -- SECTION VI. PHOTO-INDUCED HORMONE-RECEPTOR COUPLING -- Photoreactive Insulin Derivatives: Preparation and Characterization -- Photoreactive Insulin Derivatives: Chemical and Physical Properties -- The Preparation and Application of an A1-Substituted Photo-Reactive Insulin Analogue -- Photoaffinity Labeling of Insulin Receptor Proteins of Liver Plasma Membranes -- Characterisation of Insulin Binding Sites in Rat Liver Plasma Membranes Using Photoreactive Insulin Analogues -- Permanent Activation of Lipogenesis by Insulin Covalently Bound to Adipocyte Receptors -- SECTION VII. STRUCTURE, BINDING, ACTIVITY -- The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding -- Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites -- Properties of a Mutant Insulin Species Causing Human Diabetes -- A1-Modified Insulins: Receptor Binding and Biological Activity -- Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine -- Functional Role of the N-Terminal Region of the B-Chain of Insulin -- Biological Properties of Covalent Insulin Dimers -- Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin -- In vitro and in vivo Effects of Poly-N-Vinylpyrrolidone- Insulin -- Study of Insulin Action by Use of Insulin-Dextran Complex: Uptake of Insulin into Subcellular Fractions and Stimulation of Pyruvate Dehydrogenase in Mouse Adipocytes -- Studies on the Mechanism of Insulin Action VI: The Interaction of Insulin Fragments with Insulin Receptor -- Stimulation of Intracellular H2 02 Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities -- Early Events in Insulin Binding and Insulin Action in Fat Cells and Hepatocytes -- Role of the Biodegradation Process in the Action of Insulin. A Proposal for a Model Consisting of Sulfhydryl- Disulfide Interchange Reaction and Proteolysis -- Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action -- SECTION VIII. DEGRADATION -- Studies on Uptake of [3 H]-Insulin by Erythrocytes -- An Insulin-Degrading Enzyme from Human Erythrocytes: Isolation and Characterization -- Comparison of 125 I-Insulin and [B1- 3 H-Phenylalanine]- Insulin Degradation by Insulin Protease -- The Chemical Characterization of the Products of the Processing of Subcutaneously Injected Insulin -- Some Inhibitors of Insulin Degradation -- Excretion of Endogenous and Exogenous Insulin by Kidney in Diabetic Ketoacidosis -- Incubation of Insulin in Hyperglycemic Blood Generates Insulin Dimers -- SECTION IX. IMMUNOLOGY -- Genetic Regulation of the Immune Response of Mice to Insulins of Different Species -- Genetic Control of the Immune Response to Insulin -- Analysis of the Immunogenicity of Three Insulin- Preparations -- Studies on the Immunological Properties of Natural and Modified Insulins -- Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin -- The Induction of Hyperglycemia with Insulin Antibodies to B-Chain Determinants -- The Pattern of B-Lymphocyte Specificities for Modified and Unmodified Insulins in the Mouse -- Specificity of Rabbit Anti-Insulin Antibody -- Radioimmunoassay of Chemically-Modified Insulins - Use and Misuse -- Purity of Chromatographycally Purified Insulins Measured by Skin-Reactivity and Insulin-Specific IGE -- SECTION X. BIOSYNTHESIS, STORAGE, EVOLUTION -- Human Preproinsulin: Primary Structure of the Messenger RNA -- Quantification of Proinsulin Biosynthesis by Determination of Specific Radioactivity of [3 H]-Leucine in Pancreatic Islets -- Immunoreactive Rat C-Peptides I and II in Glucose Perfusate of Isolated Pancreas -- Biosynthesis of Somatostatin in Pancreatic Islets of Wistar Rats -- Crystallography of Intracellular Insulin and Glucagon as Revealed by Investigations of Tissues and Models -- Pancreatic Hormone Storage Granules: The Role of Metal Ions and Polypeptide Oligomers -- On the Molecular Biology of Hagfish Insulin -- SECTION XI. INSULIN-RELATED HORMONES -- Possible Relationships in the Processing, Storage and Secretion of Some Insulin-Related Peptides -- Insulin-Like Growth Factors -- Relaxin and Relaxin-Like Peptides in Ovaries of Pregnant Sows and Sharks -- Structural Studies on Porcine Relaxins and their Biosynthetic Precursors -- PRESENTATIONS NOT INCLUDED IN THIS VOLUME -- LIST OF PARTICIPANTS -- ABBREVIATIONS -- SUBJECT INDEX -- AUTHOR INDEX