Biophysical Theory of Radiation Action : : A Treatise on Relative Biological Effectiveness / / Wolfgang Schulz, Klaus Günther.

• VerfasserIn: Günther, Klaus,; Schulz, Wolfgang,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2022]; ©1983
• Year of Publication: 2022
• Edition: Reprint 2022
• Language: German
• Physical Description: 1 online resource (368 p.) :; with 80 Figures and 32 Tables

Table of Contents

• Frontmatter
• Preface
• Contents
• Chapter 1 Review of theoretical conceptions
• 1.1. Introduction
• 1.2. Classical target theory
• 1.3. The LET concept
• 1.4. Microdosimetry
• 1.5. Gross sensitive volume with structure
• 1.6. Some descriptive approaches to survival curves and RBE
• Chapter 2 An approximate approach based on microdosimetry
• 2.1. Introduction
• 2.2. Formalism of the microdosimetric version of theory
• 2.3. Theoretical consequences for the relative biological effectiveness
• 2.4. Analysis of experimental data
• 2.5. Primary lesions and the relevant RBE
• 2.6. Appendix
• Chapter 3 The mathematical formalism of the DNA-lesion theory of radiation action
• 3.1. Introduction
• 3.2. Prerequisites and basic principles of approximation
• 3.3. Description of radiation fields
• 3.4. Description of absorption events
• 3.5. The model of DNA-lesion production
• 3.6. The theory of cellular radiation effects
• 3.7. Formal properties and consistency of the theory
• 3.8. Appendix: estimation of errors
• Chapter 4 The underlying physical relationships
• 4.1. Introduction
• 4.2. Linear energy transfer
• 4.3. Energy spectrum of 8-rays
• 4.4. Primary ionizations and ionization cluster frequencies
• 4.5. Electron range
• 4.6. Secondary electron spectrum of photon radiation
• 4.7. Secondary charged particle spectra of fast neutrons
• Chapter 5 Implications concerning microdosimetry
• 5.1. Introduction
• 5.2. The mathematical formalism
• 5.3. Comparison with experimental data
• Chapter 6 Evaluation of the model of DNA-lesion production
• 6.1. Introduction
• 6.2. Methodic particulars
• 6.3. General results
• 6.4. DNA-strand breaks
• Chapter 7 Mammalian cell killing
• 7.1. Introduction
• 7.2. Survival curve analysis for monoenergetic ion radiations
• 7.3. Ion radiations
• 7.4. Fast neutron radiations
• Chapter 8 Re-formulation of the theory
• 8.1. Introduction
• 8.2. Virtual mierodosimetry
• 8.3. The ultimate general formalism of the theory of cellular radiation effects
• 8.4. Evaluation of RBE in LETapproximation for monoenergetic ions
• Chapter 9 Concise instructions for practical calculations
• 9.1. Introduction
• 9.2. Calculation of dose-effect relations
• 9.3. Expressing a dose-effect relation by a sum of exponential functions
• Appendix
• References
• Subject index