Biophysical Theory of Radiation Action : : A Treatise on Relative Biological Effectiveness / / Wolfgang Schulz, Klaus Günther.

• VerfasserIn: Günther, Klaus,; Schulz, Wolfgang,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2022]; ©1983
• Year of Publication: 2022
• Edition: Reprint 2022
• Language: German
• Physical Description: 1 online resource (368 p.) :; with 80 Figures and 32 Tables

Table of Contents

Frontmatter -- Preface -- Contents -- Chapter 1 Review of theoretical conceptions -- 1.1. Introduction -- 1.2. Classical target theory -- 1.3. The LET concept -- 1.4. Microdosimetry -- 1.5. Gross sensitive volume with structure -- 1.6. Some descriptive approaches to survival curves and RBE -- Chapter 2 An approximate approach based on microdosimetry -- 2.1. Introduction -- 2.2. Formalism of the microdosimetric version of theory -- 2.3. Theoretical consequences for the relative biological effectiveness -- 2.4. Analysis of experimental data -- 2.5. Primary lesions and the relevant RBE -- 2.6. Appendix -- Chapter 3 The mathematical formalism of the DNA-lesion theory of radiation action -- 3.1. Introduction -- 3.2. Prerequisites and basic principles of approximation -- 3.3. Description of radiation fields -- 3.4. Description of absorption events -- 3.5. The model of DNA-lesion production -- 3.6. The theory of cellular radiation effects -- 3.7. Formal properties and consistency of the theory -- 3.8. Appendix: estimation of errors -- Chapter 4 The underlying physical relationships -- 4.1. Introduction -- 4.2. Linear energy transfer -- 4.3. Energy spectrum of 8-rays -- 4.4. Primary ionizations and ionization cluster frequencies -- 4.5. Electron range -- 4.6. Secondary electron spectrum of photon radiation -- 4.7. Secondary charged particle spectra of fast neutrons -- Chapter 5 Implications concerning microdosimetry -- 5.1. Introduction -- 5.2. The mathematical formalism -- 5.3. Comparison with experimental data -- Chapter 6 Evaluation of the model of DNA-lesion production -- 6.1. Introduction -- 6.2. Methodic particulars -- 6.3. General results -- 6.4. DNA-strand breaks -- Chapter 7 Mammalian cell killing -- 7.1. Introduction -- 7.2. Survival curve analysis for monoenergetic ion radiations -- 7.3. Ion radiations -- 7.4. Fast neutron radiations -- Chapter 8 Re-formulation of the theory -- 8.1. Introduction -- 8.2. Virtual mierodosimetry -- 8.3. The ultimate general formalism of the theory of cellular radiation effects -- 8.4. Evaluation of RBE in LETapproximation for monoenergetic ions -- Chapter 9 Concise instructions for practical calculations -- 9.1. Introduction -- 9.2. Calculation of dose-effect relations -- 9.3. Expressing a dose-effect relation by a sum of exponential functions -- Appendix -- References -- Subject index