Basic and clinical aspects of immunity to insulin : : Proceedings, International Workshop, September 28–October 1, 1980, Konstanz / / ed. by Klaus Keck, P. Erb.

• Superior document: Title is part of eBook package: De Gruyter DGBA Medicine and Life Sciences - <1990
• MitwirkendeR: Abromson-Leeman, S.,; Arquilla, E. R.,; Bertrams, J.,; Brandenburg, D.,; Brandenburg, Dietrich,; Bucy, R. P.,; Bullesbach, E.,; Büllesbach, Erika E.,; Cantor, H.,; Cohen, I. R.,; Cohen, Irun R.,; Danho, W.,; Erb, P.,; Federlin, K.,; Fleischer, N.,; Fraga, E.,; Frenkel, A.,; Freytag, G.,; Föhles, J.,; Gattner, H.-G.,; Gotlib, Esther,; Grüneklee, D.,; Hansen, B.,; Hansen, T.,; Hedrich, H. J.,; Huber, B. T.,; Johnson, A. H.,; Kahn, R.,; Kallenberger, I.,; Kapp, J. A.,; Keck, K.,; Knorr, R.,; Kontiainen, Sirkka,; Kruse, V.,; Lin, C. S.,; Mann, D. L.,; Maron, Ruth,; Maser, E.,; Mayr, W. R.,; Mendell, N.,; Michalski, R. E.,; Momayezi, M.,; Mäser, E.,; Naithani, V. K.,; Neubauer, H. P.,; Nielsen, J. Høiriis,; Paik, S.-G.,; Petersen, K.-G.,; Prujansky-Jakobovitz, A.,; Ramila, G.,; Rapp, B. J.,; Reeves, W. G.,; Reske-Kunz, A.,; Rosenthal, A. S.,; Rosenwasser, L. J.,; Rude, E.,; Scheinin, Tom,; Schernthaner, G.,; Schlüter, K.,; Schmitt, E. W.,; Schroer, J. A.,; Schroer, J.,; Schöne, H. H.,; Schüttler, A.,; Schüttler, Achim,; Sharon, N.,; Shin, S.,; Singh, B.,; Sklenar, I.,; Spaeth, E.,; Studer, S.,; Stötter, H.,; Talmon, Janet,; Thomas, J. W.,; Thomas, K.,; Thompson, R.,; Trindler, Peter,; Valdes, I.,; Velcovsky, H. G.,; Velcovsky, H.-G.,; Vogt, P.,; Weimann, Hans-Josef,; Welinder, B.,; Zahn, H.,; Zimmermann, F.,; Zoumbou, E.,
• HerausgeberIn: Erb, P.,; Keck, Klaus,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2019]; ©1981
• Year of Publication: 2019
• Edition: Reprint 2019
• Language: English
• Physical Description: 1 online resource (442 p.) :; Num. figs.

Table of Contents

Frontmatter -- PREFACE -- LIST OF PARTICIPANTS -- CONTENTS -- SECTION I. BASIC ASPECTS OF IMMUNITY TO INSULIN -- Introduction: Insulin as a tool for the study of immunological problems -- Genetic control of the immune response to insulin -- Analysis of the in vitro induction of insulin-specific helper T cells -- Immunogenic determinants of insulin: Synthesis and immunogenicity of the A-chain loop peptides of beef insulin -- Analysis of H-2 gene regulation of the response of T lymphocytes to insulin using synthetic antigenic determinants and anti-idiotypes -- Ir gene control of the insulin-specific immune response in mice -- Influence of insulin modification upon the immune response to insulin -- Function and complementation of Ir genes controlling the responsiveness of mice to insulin -- The XID gene controls Ia.W39 associated immune response gene function for insulin induced T cell activation -- Induction of immunity and suppression by pig insulin in mice -- Genetic control of anti-insulin responses is associated with activation of different T-cell sets -- Suppression of insulin responses in vitro -- Immune response phenotype of insulin-presenting cells modified by insertion of H-2 gene products into cell membranes -- Differences in insulin antibodies induced with varying antigenic forms -- Mouse hybridoma antibody recognition of the insulin molecule -- SECTION II. CLINICAL ASPECTS OF IMMUNITY TO INSULIN -- Clinical aspects of immunity to insulin -- Antibody production during insulin therapy - patterns of response and clinical sequels -- Studies of the immunogenicity of chromatographically purified insulins in Type-I and Type-II diabetics -- Genetic control of the IgE response to insulin -- HLA-DR association of humoral immunoresponsiveness to insulin in insulin-dependent (Type I) diabetes mellitus -- Insulin antibody formation following conventional or monocomponent insulin treatment is influenced by genes of the HLA-DR locus -- A study of HLA alloantigen frequencies in insulin allergic and non-allergic diabetics -- Morphologic changes in pancreas islets after active or passive immunization against insulin: a review -- The role of autoimmune processes in the development of insulin-dependent diabetes mellitus in mice treated with streptozotocin -- Effect of insulin-binding antibodies of free insulin in plasma and tissue after subcutaneous injection. A model study -- Immunogenicity of insulin in relation to its physicochemical properties -- Potentation of insulin immunogenicity by different types of adjuvant -- Use of modified insulins for the separation of insulin antibodies by affinity chromatography -- The immunogenicity of insulin from our point of view -- SECTION III. CHEMISTRY TO INSULIN -- Preparation of insulins with modified N-terminals by semisynthesis and chemical modification of the native hormone -- Synthesis of insulin analogues -- Modification of the C-terminal region of insulin -- SUBJECT INDEX -- AUTHOR INDEX