Basic and clinical aspects of immunity to insulin : : Proceedings, International Workshop, September 28–October 1, 1980, Konstanz / / ed. by Klaus Keck, P. Erb.
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Other title: | Frontmatter -- PREFACE -- LIST OF PARTICIPANTS -- CONTENTS -- SECTION I. BASIC ASPECTS OF IMMUNITY TO INSULIN -- Introduction: Insulin as a tool for the study of immunological problems -- Genetic control of the immune response to insulin -- Analysis of the in vitro induction of insulin-specific helper T cells -- Immunogenic determinants of insulin: Synthesis and immunogenicity of the A-chain loop peptides of beef insulin -- Analysis of H-2 gene regulation of the response of T lymphocytes to insulin using synthetic antigenic determinants and anti-idiotypes -- Ir gene control of the insulin-specific immune response in mice -- Influence of insulin modification upon the immune response to insulin -- Function and complementation of Ir genes controlling the responsiveness of mice to insulin -- The XID gene controls Ia.W39 associated immune response gene function for insulin induced T cell activation -- Induction of immunity and suppression by pig insulin in mice -- Genetic control of anti-insulin responses is associated with activation of different T-cell sets -- Suppression of insulin responses in vitro -- Immune response phenotype of insulin-presenting cells modified by insertion of H-2 gene products into cell membranes -- Differences in insulin antibodies induced with varying antigenic forms -- Mouse hybridoma antibody recognition of the insulin molecule -- SECTION II. CLINICAL ASPECTS OF IMMUNITY TO INSULIN -- Clinical aspects of immunity to insulin -- Antibody production during insulin therapy - patterns of response and clinical sequels -- Studies of the immunogenicity of chromatographically purified insulins in Type-I and Type-II diabetics -- Genetic control of the IgE response to insulin -- HLA-DR association of humoral immunoresponsiveness to insulin in insulin-dependent (Type I) diabetes mellitus -- Insulin antibody formation following conventional or monocomponent insulin treatment is influenced by genes of the HLA-DR locus -- A study of HLA alloantigen frequencies in insulin allergic and non-allergic diabetics -- Morphologic changes in pancreas islets after active or passive immunization against insulin: a review -- The role of autoimmune processes in the development of insulin-dependent diabetes mellitus in mice treated with streptozotocin -- Effect of insulin-binding antibodies of free insulin in plasma and tissue after subcutaneous injection. A model study -- Immunogenicity of insulin in relation to its physicochemical properties -- Potentation of insulin immunogenicity by different types of adjuvant -- Use of modified insulins for the separation of insulin antibodies by affinity chromatography -- The immunogenicity of insulin from our point of view -- SECTION III. CHEMISTRY TO INSULIN -- Preparation of insulins with modified N-terminals by semisynthesis and chemical modification of the native hormone -- Synthesis of insulin analogues -- Modification of the C-terminal region of insulin -- SUBJECT INDEX -- AUTHOR INDEX |
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Format: | Mode of access: Internet via World Wide Web. |
ISBN: | 9783111518053 9783110637861 |
DOI: | 10.1515/9783111518053 |
Access: | restricted access |
Hierarchical level: | Monograph |
Statement of Responsibility: | ed. by Klaus Keck, P. Erb. |
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