Vitamin B12 : : Proceedings of the 3rd European Symposium on Vitamin B12 and Intrinsic Factor, University of Zurich, March 5–8, 1979, Zurich, Switzerland / / ed. by B. Zagalak, Universität ‹Zürich›, 1979, Zürich› European Symposium on Vitamin B 12 and Intrinsic Factor ‹3, W. Friedrich.
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Table of Contents:
- Frontmatter
- Preface
- CONTENTS
- Chapter 1. CHEMISTRY OF CORRINOIDS. TOTAL SYNTHESIS OF VITAMIN B12
- Introductory remarks for opening of 3rd European Symposium on vitamin B12
- Introductory remarks. Historical perspectives on the isolation of crystalline vitamin B12
- New and old problems in the structure analysis of vitamin B12
- Synthetic vitamin B12
- Chemical synthesis of corrinoids: current problems and recent advances
- Recent studies on the synthesis of vitamin B12
- New reactions of the chromophoric system of vitamin B12 derivatives
- Structure and reactivity of the so-called stable yellow corrinoids
- Concerning the structure of so-called yellow products obtained from naturally occurring metal-free corrinoids
- Correlation of vitamin B12 methanolysis products with cobyrinic methyl ester amides prepared from hydrogenobyrinic acid amides
- Preparation and X-ray structural analyses of a cobyrinic acid diamide and the corresponding rhodium analogue
- Concerning a new corrinoid from municipal sludge
- Steric course of the substitution by vitamin B12s as studied by 1H-NMR spectroscopy
- Synthesis and X-ray analysis of a porphyrin-type Co(I)-complex
- Stereochemistry of the formation and cleavage of the Co-C bond in a vitamin B12 model
- The structure of superoxocobalamin, a single crystal ESR study
- NMR studies of a novel form of vitamin B12
- Circular dichroism study of organocobalamins
- Concerning electronic, CD and ORD spectra of isomeric pairs of several (Co-methyl)-corrinoids
- Some properties of cobalaminhexacyanoferrate
- Temperature-jump kinetics of the "base-on" - "base-off" equilibrium of methylcobalamin
- Electrochemistry of vitamin B12. Equilibria, kinetics and mechanisms in the B12a - B12r - B12s oxido-reduction
- Electrochemistry of vitamin B12. Alkyl cobalamins and cobinamides
- Chapter 2. BIOSYNTHESIS OF CORRINOIDS
- Recent biosynthetic researches on vitamin B12
- Intermediary metabolism of cobyrinic acid biosynthesis
- On the methylation process in cobyrinic acid biosynthesis
- Biogenesis of tetrapyrrole compounds (porphyrins and corrinoids), and its regulation
- Factor I ex Clostridium tetanomorphum: proof of structure and relationship to vitamin B12 biosynthesis
- On the biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B12
- The enzyme system of propionic acid bacteria transforming riboflavin into 5,6-dimethylbenzimidazole
- Straight approaches to the nucleotide loop
- Ribosomal proteins share in vitamin B12 biosynthesis
- The ribosomal proteins L2, L5, L18 and L25 involved in vitamin B12 biosynthesis
- Formation and role of vitamin B12 in Protaminobacter ruber and Rhizobium meliloti
- Chapter 3. CORRINOID DEPENDENT ENZYMES AND REACTIONS. MODEL SYSTEMS
- Current status of the mechanism of action of B12 - coenzyme
- A stereochemical approach to the diol dehydratase reaction
- Coenzyme B12-dependent diol dehydratase - distribution and metabolic role in Enterobacteriaceae, enzymological properties and interaction with coenzyme B12
- Adenosylcobalamin-dependent glycerol dehydratase interaction with substrates and their analogs
- Glycerol dehydratase from Aerobacter aerogenes
- The mechanism of action of methylmalonyl-CoA mutase as studied with isotope labelling and synthetic models
- Recent studies on the mechanism of action of ethanolamine ammonia-lyase
- Studies on the mechanism of reactions catalysed by ethanolamine ammonia-lyase
- Steric course of the ethanolamine-ammonia lyase reaction
- The chemical synthesis and coenzymatic properties of analogs of adenosylcobalamin in the ribonucleotide reductase reaction
- Review of the EPR of B12r and B12 -dependent enzyme reactions
- Vitamin B12: current problems and recent advances
- The role of corrinoids in the total synthesis of acetate from C02
- Mechanisms for B12 -dependent methylation
- Nonenzymic models for the enigmatic coenzyme B12-dependent carbon-skeleton rearrangements
- The mechanism of action of coenzyme B12
- Model systems for adenosylcobalamin dependent enzymic reactions
- Bridged cobaloximes as vitamin B12 models
- Modified adenosylaobalamin: model systems for the active sites of corrinoid-dependent enzymes
- Chapter 4. ANALOGUES AND ANTAGONISTS OF VITAMIN B12
- Naturally occurring vitamin B12 antagonists and their potential therapeutic value
- Structures of some vitamin B12 analogues and their biological as well as biochemical functions
- Novel metal-free corrinoids and metal analogues
- Preparation of ferribalamin, the Fe(III)-analogue of vitamin B12
- Chapter 5. VITAMIN B12 ASSAY
- Vitamin B12 assay: an evaluation of radiodilution assay using cobinamide to increase specificity
- Effect of residual extract products and the type of binders (R or IF) on serum vitamin B12 levels by radioisotope dilution assay
- Differential assay of cobamides in serum using R-protein radioisotopic dilution assay, E.coli and E.gracilis assays
- Rapid determination of corrinoids by high performance liquid chromatography
- Determination of the plasma cobalamins by one-dimensional thin-layer chromatography
- Chemical quantitation of corrinoids
- Enzymatic estimation of vitamin B12
- Essential prerequisites for the analysis of cyanocobalamin in biochemically complex samples using radiometric competitive binding assays
- Chapter 6. ABSORPTION, TRANSPORT AND DISTRIBUTION OF VITAMIN B12
- Distribution of cobalamins in the animal body
- Vitamin B12 in membrane mimetic agents - theoretical considerations and practical applications
- Transport of vitamin B12 in Escherichia coli
- The plasma transport of cobalamin (Cbl)
- Soluble and membrane-bound vitamin B12 transport proteins
- The origin and clinical implications of vitamin B12 binders - the transcobalamins
- Large vitamin B12-binding proteins and complexes in human serum
- Heterogeneity of antibodies against B12 binders in pernicious anaemia
- The intraluminal phase of vitamin B12 transport in humans
- Polymorphic variants of transcobalamin II rare alleles in family studies
- Relationship between cobalophilin releasing and functional state of polymorphonuclear granulocytes
- The significance of vitamin B12 binders in the central nervous system
- In vitro acid dissociation of cobalamin-transcobalamin II complexes formed in vivo: a probe in the study of TC II-kinetics
- Calcium dependencies in the binding of transcobalamins to subcellular particles of liver cells
- The effect of antibiotics on transcobalamin II synthesis in rabbit liver cell culture
- Solubilization and characterization of the transcobalamin II acceptor from human placenta and rabbit liver
- Strength of binding of methyl-, 5 '-deoxyadenosyl-, cyano- and hydroxocobalamin to human transcobalamin I and II and intrinsic factor
- Adsorptive endocytosis of transcobalamin II-vitamin B12 by isolated rat liver parenchymal cells
- Species specificity between TC II, TC II-Cbl uptake and anti-TC II
- Transcobalamin II polymorphism in african populations
- Transcobalamins during induction of nutritional cobalamin deficiency in the fruit bat
- Heterogeneity of transcobalamin II demonstrated by isoelectric focusing in urea
- Radioimmunosorbent determinations of unsaturated and total transcobalamin II in human serum
- The "dU suppression test" and "thymidine suppression test": evidence for reciprocal relationship between the "de novo" and "salvage" pathways of DNA synthesis
- TC II deficiency: observations with deoxyuridine suppression test
- Spectral studies on hog intrinsic factor and hog non-intrinsic factor
- Amino terminal sequence of hog non-intrinsic factor and hog intrinsic factor
- Subunit structure of the pig ileal intrinsic factor receptor
- Cobinamide blocking assay for intrinsic factor
- Intracelular transport of vitamin B12 in enterocytes
- Evidence for the chief cell as the source of intrinsic factor secretion in the rat
- Long-term treatment of pernicious anemia patients with intrinsic factor
- An analogy of cobalamin membrane transport: an intestinal receptor for heme
- A simplified method for quantitative determination of vitamin B12 absorption
- Vitamin B12 absorption studies with plastic whole body counter in
- patients with gastroenterological operation
- Affinity photo-release purification of cobalamin-binding proteins
- Effect of pentagastrin in vitamin B12 absorption in the guinea pig
- Synthesis of cobalamin coenzymes in the rat and their secretion from the liver into plasma and bile
- The pattern of cobalamins in human erythrocytes
- Presence of sulfitocobalamin in cell extracts. Resolution and identification by SP-Sephadex C-25 cation exchange chromatography
- Mitochondrial cobalamins: types, sources, and functions with evidence of their noninvolvement in mitochondrial DNA synthesis
- Chapter 7. PHYSIOLOGY AND PATHOLOGY OF VITAMIN B12
- Studies on vitamin B12 and ubiquinone
- Haematological aspects of cobalamin deficiency
- The neurology of vitamin B12 deficiency
- Clinioal diseases related to defioienoies of vitamin B12 transport proteins
- Effects of methylaobalamin on peripheral neuropathies or experimentally-induced neuropathies
- Inherited deficiencies of the deoxyadenosylcobalamin (Ado-Cbl) dependent L-methylmalonyl-CoA mutase system: clinical and biochemical aspects
- An investigation of a possible role for coenzyme B12 in ribonucleotide reduction in rabbit bone marrow
- Participation of cAMP in regulation of coenzyme B12 dependent glycerol dehydratase synthesis from Klebsiella pneumoniae ATCC 85955
- Carbon monoxide oxidation by Clostridia: evidence for the involvement of a corrinoid-like compound
- The in vivo effects of nitrous oxide on human bone marrow - a morphological, biochemical and cell cycle study
- Interconversion of cobalamins in human lymphocytes in vitro and the influence of nitrous oxide on synthesis of cobalamin coenzymes
- Studies on cobalamin and folate metabolism in rats exposed to nitrous oxide (N2O)
- Alterations in mammalian cells induced by inactivation of vitamin B12 with nitrous oxide
- High ascorbic acid intake and vitamin B12 status in the rat
- Ability of megadoses of vitamin C to destroy vitamin B12 and cobinamide and to reduce absorption of vitamin B12 (with a note on B12 radioassays)
- Interaction between methylcobalamin and some amino acids in single cell proteins
- Methylcobalamin and the modification of proteins in vitro
- Deoxyadenosylcobalamin and the process of methylation of tRNA in model systems
- The participation of coenzyme B12 in the synthesis of DNA by Propionibacterium shermanii
- Recent advances in cobalamin metabolism: abnormalities in coenzyme distribution in tumor development and in inherited metabolic disease
- On some properties of the effect and metabolism of different cobalamins in tumor-bearing rats
- Gastric cancer as a risk factor in pernicious anaemia
- Interference with cobalamin metabolism and tumour growth by an analogue of methylcobalamin
- Vitamin B12 requirement for replication of mouse leukemia L1210 cells: functional relevance to folate metabolism
- Vitamin B12 and folia acid interrelations: a new look
- The effect of hypothyroidism on histidine oxidation and folate-dependent enzyme levels
- Cobalamin-dependent methionine synthesis and the regulation of the metabolism of activated folic acid derivatives in cultured human lymphoblasts
- Author and Citation Index
- Subject Index
- Collection of Photographs from the Symposium
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