Vitamin B12 : : Proceedings of the 3rd European Symposium on Vitamin B12 and Intrinsic Factor, University of Zurich, March 5–8, 1979, Zurich, Switzerland / / ed. by B. Zagalak, Universität ‹Zürich›, 1979, Zürich› European Symposium on Vitamin B 12 and Intrinsic Factor ‹3, W. Friedrich.
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Other title: | Frontmatter -- Preface -- CONTENTS -- Chapter 1. CHEMISTRY OF CORRINOIDS. TOTAL SYNTHESIS OF VITAMIN B12 -- Introductory remarks for opening of 3rd European Symposium on vitamin B12 -- Introductory remarks. Historical perspectives on the isolation of crystalline vitamin B12 -- New and old problems in the structure analysis of vitamin B12 -- Synthetic vitamin B12 -- Chemical synthesis of corrinoids: current problems and recent advances -- Recent studies on the synthesis of vitamin B12 -- New reactions of the chromophoric system of vitamin B12 derivatives -- Structure and reactivity of the so-called stable yellow corrinoids -- Concerning the structure of so-called yellow products obtained from naturally occurring metal-free corrinoids -- Correlation of vitamin B12 methanolysis products with cobyrinic methyl ester amides prepared from hydrogenobyrinic acid amides -- Preparation and X-ray structural analyses of a cobyrinic acid diamide and the corresponding rhodium analogue -- Concerning a new corrinoid from municipal sludge -- Steric course of the substitution by vitamin B12s as studied by 1H-NMR spectroscopy -- Synthesis and X-ray analysis of a porphyrin-type Co(I)-complex -- Stereochemistry of the formation and cleavage of the Co-C bond in a vitamin B12 model -- The structure of superoxocobalamin, a single crystal ESR study -- NMR studies of a novel form of vitamin B12 -- Circular dichroism study of organocobalamins -- Concerning electronic, CD and ORD spectra of isomeric pairs of several (Co-methyl)-corrinoids -- Some properties of cobalaminhexacyanoferrate -- Temperature-jump kinetics of the "base-on" - "base-off" equilibrium of methylcobalamin -- Electrochemistry of vitamin B12. Equilibria, kinetics and mechanisms in the B12a - B12r - B12s oxido-reduction -- Electrochemistry of vitamin B12. Alkyl cobalamins and cobinamides -- Chapter 2. BIOSYNTHESIS OF CORRINOIDS -- Recent biosynthetic researches on vitamin B12 -- Intermediary metabolism of cobyrinic acid biosynthesis -- On the methylation process in cobyrinic acid biosynthesis -- Biogenesis of tetrapyrrole compounds (porphyrins and corrinoids), and its regulation -- Factor I ex Clostridium tetanomorphum: proof of structure and relationship to vitamin B12 biosynthesis -- On the biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B12 -- The enzyme system of propionic acid bacteria transforming riboflavin into 5,6-dimethylbenzimidazole -- Straight approaches to the nucleotide loop -- Ribosomal proteins share in vitamin B12 biosynthesis -- The ribosomal proteins L2, L5, L18 and L25 involved in vitamin B12 biosynthesis -- Formation and role of vitamin B12 in Protaminobacter ruber and Rhizobium meliloti -- Chapter 3. CORRINOID DEPENDENT ENZYMES AND REACTIONS. MODEL SYSTEMS -- Current status of the mechanism of action of B12 - coenzyme -- A stereochemical approach to the diol dehydratase reaction -- Coenzyme B12-dependent diol dehydratase - distribution and metabolic role in Enterobacteriaceae, enzymological properties and interaction with coenzyme B12 -- Adenosylcobalamin-dependent glycerol dehydratase interaction with substrates and their analogs -- Glycerol dehydratase from Aerobacter aerogenes -- The mechanism of action of methylmalonyl-CoA mutase as studied with isotope labelling and synthetic models -- Recent studies on the mechanism of action of ethanolamine ammonia-lyase -- Studies on the mechanism of reactions catalysed by ethanolamine ammonia-lyase -- Steric course of the ethanolamine-ammonia lyase reaction -- The chemical synthesis and coenzymatic properties of analogs of adenosylcobalamin in the ribonucleotide reductase reaction -- Review of the EPR of B12r and B12 -dependent enzyme reactions -- Vitamin B12: current problems and recent advances -- The role of corrinoids in the total synthesis of acetate from C02 -- Mechanisms for B12 -dependent methylation -- Nonenzymic models for the enigmatic coenzyme B12-dependent carbon-skeleton rearrangements -- The mechanism of action of coenzyme B12 -- Model systems for adenosylcobalamin dependent enzymic reactions -- Bridged cobaloximes as vitamin B12 models -- Modified adenosylaobalamin: model systems for the active sites of corrinoid-dependent enzymes -- Chapter 4. ANALOGUES AND ANTAGONISTS OF VITAMIN B12 -- Naturally occurring vitamin B12 antagonists and their potential therapeutic value -- Structures of some vitamin B12 analogues and their biological as well as biochemical functions -- Novel metal-free corrinoids and metal analogues -- Preparation of ferribalamin, the Fe(III)-analogue of vitamin B12 -- Chapter 5. VITAMIN B12 ASSAY -- Vitamin B12 assay: an evaluation of radiodilution assay using cobinamide to increase specificity -- Effect of residual extract products and the type of binders (R or IF) on serum vitamin B12 levels by radioisotope dilution assay -- Differential assay of cobamides in serum using R-protein radioisotopic dilution assay, E.coli and E.gracilis assays -- Rapid determination of corrinoids by high performance liquid chromatography -- Determination of the plasma cobalamins by one-dimensional thin-layer chromatography -- Chemical quantitation of corrinoids -- Enzymatic estimation of vitamin B12 -- Essential prerequisites for the analysis of cyanocobalamin in biochemically complex samples using radiometric competitive binding assays -- Chapter 6. ABSORPTION, TRANSPORT AND DISTRIBUTION OF VITAMIN B12 -- Distribution of cobalamins in the animal body -- Vitamin B12 in membrane mimetic agents - theoretical considerations and practical applications -- Transport of vitamin B12 in Escherichia coli -- The plasma transport of cobalamin (Cbl) -- Soluble and membrane-bound vitamin B12 transport proteins -- The origin and clinical implications of vitamin B12 binders - the transcobalamins -- Large vitamin B12-binding proteins and complexes in human serum -- Heterogeneity of antibodies against B12 binders in pernicious anaemia -- The intraluminal phase of vitamin B12 transport in humans -- Polymorphic variants of transcobalamin II rare alleles in family studies -- Relationship between cobalophilin releasing and functional state of polymorphonuclear granulocytes -- The significance of vitamin B12 binders in the central nervous system -- In vitro acid dissociation of cobalamin-transcobalamin II complexes formed in vivo: a probe in the study of TC II-kinetics -- Calcium dependencies in the binding of transcobalamins to subcellular particles of liver cells -- The effect of antibiotics on transcobalamin II synthesis in rabbit liver cell culture -- Solubilization and characterization of the transcobalamin II acceptor from human placenta and rabbit liver -- Strength of binding of methyl-, 5 '-deoxyadenosyl-, cyano- and hydroxocobalamin to human transcobalamin I and II and intrinsic factor -- Adsorptive endocytosis of transcobalamin II-vitamin B12 by isolated rat liver parenchymal cells -- Species specificity between TC II, TC II-Cbl uptake and anti-TC II -- Transcobalamin II polymorphism in african populations -- Transcobalamins during induction of nutritional cobalamin deficiency in the fruit bat -- Heterogeneity of transcobalamin II demonstrated by isoelectric focusing in urea -- Radioimmunosorbent determinations of unsaturated and total transcobalamin II in human serum -- The "dU suppression test" and "thymidine suppression test": evidence for reciprocal relationship between the "de novo" and "salvage" pathways of DNA synthesis -- TC II deficiency: observations with deoxyuridine suppression test -- Spectral studies on hog intrinsic factor and hog non-intrinsic factor -- Amino terminal sequence of hog non-intrinsic factor and hog intrinsic factor -- Subunit structure of the pig ileal intrinsic factor receptor -- Cobinamide blocking assay for intrinsic factor -- Intracelular transport of vitamin B12 in enterocytes -- Evidence for the chief cell as the source of intrinsic factor secretion in the rat -- Long-term treatment of pernicious anemia patients with intrinsic factor -- An analogy of cobalamin membrane transport: an intestinal receptor for heme -- A simplified method for quantitative determination of vitamin B12 absorption -- Vitamin B12 absorption studies with plastic whole body counter in patients with gastroenterological operation -- Affinity photo-release purification of cobalamin-binding proteins -- Effect of pentagastrin in vitamin B12 absorption in the guinea pig -- Synthesis of cobalamin coenzymes in the rat and their secretion from the liver into plasma and bile -- The pattern of cobalamins in human erythrocytes -- Presence of sulfitocobalamin in cell extracts. Resolution and identification by SP-Sephadex C-25 cation exchange chromatography -- Mitochondrial cobalamins: types, sources, and functions with evidence of their noninvolvement in mitochondrial DNA synthesis -- Chapter 7. PHYSIOLOGY AND PATHOLOGY OF VITAMIN B12 -- Studies on vitamin B12 and ubiquinone -- Haematological aspects of cobalamin deficiency -- The neurology of vitamin B12 deficiency -- Clinioal diseases related to defioienoies of vitamin B12 transport proteins -- Effects of methylaobalamin on peripheral neuropathies or experimentally-induced neuropathies -- Inherited deficiencies of the deoxyadenosylcobalamin (Ado-Cbl) dependent L-methylmalonyl-CoA mutase system: clinical and biochemical aspects -- An investigation of a possible role for coenzyme B12 in ribonucleotide reduction in rabbit bone marrow -- Participation of cAMP in regulation of coenzyme B12 dependent glycerol dehydratase synthesis from Klebsiella pneumoniae ATCC 85955 -- Carbon monoxide oxidation by Clostridia: evidence for the involvement of a corrinoid-like compound -- The in vivo effects of nitrous oxide on human bone marrow - a morphological, biochemical and cell cycle study -- Interconversion of cobalamins in human lymphocytes in vitro and the influence of nitrous oxide on synthesis of cobalamin coenzymes -- Studies on cobalamin and folate metabolism in rats exposed to nitrous oxide (N2O) -- Alterations in mammalian cells induced by inactivation of vitamin B12 with nitrous oxide -- High ascorbic acid intake and vitamin B12 status in the rat -- Ability of megadoses of vitamin C to destroy vitamin B12 and cobinamide and to reduce absorption of vitamin B12 (with a note on B12 radioassays) -- Interaction between methylcobalamin and some amino acids in single cell proteins -- Methylcobalamin and the modification of proteins in vitro -- Deoxyadenosylcobalamin and the process of methylation of tRNA in model systems -- The participation of coenzyme B12 in the synthesis of DNA by Propionibacterium shermanii -- Recent advances in cobalamin metabolism: abnormalities in coenzyme distribution in tumor development and in inherited metabolic disease -- On some properties of the effect and metabolism of different cobalamins in tumor-bearing rats -- Gastric cancer as a risk factor in pernicious anaemia -- Interference with cobalamin metabolism and tumour growth by an analogue of methylcobalamin -- Vitamin B12 requirement for replication of mouse leukemia L1210 cells: functional relevance to folate metabolism -- Vitamin B12 and folia acid interrelations: a new look -- The effect of hypothyroidism on histidine oxidation and folate-dependent enzyme levels -- Cobalamin-dependent methionine synthesis and the regulation of the metabolism of activated folic acid derivatives in cultured human lymphoblasts -- Author and Citation Index -- Subject Index -- Collection of Photographs from the Symposium |
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Format: | Mode of access: Internet via World Wide Web. |
ISBN: | 9783111510828 9783110637861 |
DOI: | 10.1515/9783111510828 |
Access: | restricted access |
Hierarchical level: | Monograph |
Statement of Responsibility: | ed. by B. Zagalak, Universität ‹Zürich›, 1979, Zürich› European Symposium on Vitamin B 12 and Intrinsic Factor ‹3, W. Friedrich. |
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