Vitamin B12 : : Proceedings of the 3rd European Symposium on Vitamin B12 and Intrinsic Factor, University of Zurich, March 5–8, 1979, Zurich, Switzerland / / ed. by B. Zagalak, Universität ‹Zürich›, 1979, Zürich› European Symposium on Vitamin B 12 and Intrinsic Factor ‹3, W. Friedrich.

• Superior document: Title is part of eBook package: De Gruyter DGBA Medicine and Life Sciences - <1990
• MitwirkendeR: Abeles, R. H.,; Abels, J.,; Aleksiene, A. M.,; Alioniene, A. J.,; Amess, J. A. L.,; Angelova, S.,; Anton, D. L.,; Antoshkina, N. V.,; Arigoni, D.,; Atkins, M. P.,; Awtrey, A. W.,; Babior, B. M.,; Babior, Bernard M.,; Banks, A. R.,; Bartkeviciene, V. V.,; Bash, R.,; Battersby, A. R.,; Baumgartner, R.,; Beck, R. A.,; Beck, William S.,; Becker, Carter M.,; Begley, A.,; Begley, James A.,; Bieganowski, R.,; Boduch, K.,; Bradbeer, Clive,; Brazenas, G. R.,; Brody, T.,; Broekelmann, T. J.,; Brown, K. L.,; Bucher, D.,; Burman, J. F.,; Bykhovsky, V. Ya.,; Bütler, R.,; Carmel, Ralph,; Chanarin, I.,; Chock, P. B.,; Choe, J. Y.,; Cohen, Raphael,; Colman, N.,; Cooksley, W. G. E.,; Cooper, B. A.,; Crowfoot Hodgkin, Dorothy,; Cullen, M. H.,; Cullen, W. R.,; Cutler, A. R.,; Das, K. C.,; Deacon, Rosemary,; Deeg, R.,; Diekert, G. B.,; Dinn, J.,; Diziol, P.,; Dolphin, D.,; Dowd, Paul,; Dresow, B.,; Elsborg, L.,; Engel, P.,; England, J. M.,; Ernst, L.,; Eschenmoser, A.,; Fanchiang, Y.-T.,; Fendler, Janos H.,; Fenrych, W.,; Folkers, K.,; Fountoulakis, M.,; Frater-Schröder, M.,; Friedmann, H. C.,; Friedrich, W.,; Fràter-Schröder, Marijke,; Fujii, Katsuhiko,; Fukui, Saburo,; Gilbert, H.,; Gimsing, P.,; Gneuß, K. D.,; Golding, B. T.,; Gossauer, A.,; Goswami, P. C.,; Graf, E. G.,; Grate, J. H.,; Graves, S.,; Green, Pamela D.,; Green, R.,; Grosberg, S.,; Gräsbeck, R.,; Gräsbeck, Ralph,; Grüning, B.,; Gunzer, G.,; Gupta, R. K.,; Günthard, Hs. H.,; Haas, H.,; Hall, Charles A.,; Halsey, M. J.,; Hansen, Marianne R.,; Hansz, J.,; Hashimoto, M.,; Hasler-Häkkinen, Aila,; Hauptmann, E.,; Haurani, F. I.,; Haus, Mary,; Hayashi, M.,; Herbert, V.,; Hippe, E.,; Hitzig, W. H.,; Hoffbrand, A. V.,; Hogenkamp, H. P. C.,; Hollaway, M. R.,; Hollenberg, M. D.,; Holländer, N. H.,; Hopper, Sarah,; Horton, M. A.,; Huennekens, F. M.,; Hussein, H. A.,; Häkkinen, A. K.,; Hörig, J.,; Imfeld, M.,; Inada, M.,; Inhoffen, H. H.,; Inukai, S.,; Izumi, Y.,; Jackson, Beverley,; Jacobsen, D.,; Jaenicke, L.,; Jaszewski, B.,; Joblin, K. N.,; Johnson, A. W.,; Jonas, Erika,; Jordan, E. P.,; Jorgensen, Jens,; Jörin, E.,; Kalnev, V. R.,; Kameyama, H.,; Kameyama, M.,; Kamikubo, T.,; Kanopkaite, S. J.,; Kapel, J. van,; Katz, M.,; Koppenhagen, V. B.,; Korsova, T. L.,; Kouvonen, I.,; Kouvonen, Ilkka,; Kriemler, H. -P.,; Kwen, Y. Z.,; Landau, L.,; Lappert, M. F.,; Lexa, D.,; Lindemans, J.,; Linnell, J. C.,; Lumb, M.,; Lundberg, Margaretha,; M., O.,; Maihub, A.,; Malleson, P. N.,; Marcoullis, G.,; Matthews, D. M.,; May-Sheng Chan, Margaret,; McCann, S.,; Minty, Barbara,; Mollin, D. L.,; Montejano, Y.,; Morishita, R.,; Mosbech, J.,; Moskophidis, M.,; Muir, M.,; Myasishcheva, N. V.,; Myers, P.,; Müller, G.,; Nagasaki, Tomohisa,; Nath, A.,; Nexø, Ebba,; Nicolas, J. P.,; Nishii, S.,; Nunn, J. F.,; Ogawa, M.,; Olesen, H.,; Osusky, R.,; Owens, J. A.,; O’Sullivan, H.,; Parmentier, Y.,; Perlman, D.,; Perlman, K. L.,; Perrin, M. O.,; Perry, Janet,; Peyman, J.,; Pezacka, E.,; Pilbrow, John R.,; Popova, Y.,; Porck, H. J.,; Pospelova, T. A.,; Poznanskaya, A. A.,; Pytlak, B.,; Quadros, E. V.,; Rabinowitz, R.,; Rachmilewitz, B.,; Rachmilewitz, M.,; Rackus, J. A.,; Reed, B.,; Renz, P.,; Reynolds, E. H.,; Rhee, S. G.,; Robinson, J. A.,; Rudakova, I. P.,; Rytz, G.,; Rétey, J.,; S., P. R.,; Salonen, E. -M.,; Sato, K.,; Sauer, H.,; Savage, M.,; Savéant, J. M.,; Scheffold, R.,; Schlesinger, M.,; Schlingmann, G.,; Schneider, Zenon,; Schrauzer, G. N.,; Schweiger, A.,; Schömer, U.,; Scott, A. I.,; Scott, J. M.,; Seger, R.,; Seki, T.,; Sellars, P. J.,; Sharpe, P. C.,; Sheldrick, W. S.,; Shimizu, S.,; Shizukuishi, S.,; Silverman, R. B.,; Skupin, J.,; Soufflet, J. P.,; Sourial, N. A.,; Stankevicius, V. A.,; Stenman, U.-H.,; Stevens, R. V.,; Stokstad, E. L. R.,; Stopa, E.,; Stroinski, A.,; Tacconi, N. de,; Tachkova, E. M.,; Tan, C. H.,; Taraseviciene, L. E.,; Tavill, A. S.,; Tenhunen, R.,; Thauer, R. K.,; Thomsen, J.,; Todd, Lord,; Toraya, Tetsuo,; Toyoshima, M.,; Trachtenberg, Alan,; Uchino, H.,; Udaka, F.,; Ueda, S.,; Vares, Y. V.,; Vitins, P.,; Vorobjeva, L. I.,; Vögeli, U.,; Walder, L.,; Walerych, W.,; Waliszewski, K.,; Wallis, O. C.,; Warmuth, E.,; Warnock Thenen, Shirley,; Watson, J. E.,; Weir, D. G.,; White, H. A.,; Whitehead, V. M.,; Wick, H.,; Williams, T. H.,; Wilson, P.,; Wood, Harland G.,; Wood, J. M.,; Woodward, R. B.,; Wurm, R.,; Yki-Järvinen, Hannele,; Yurkevich, A. M.,; Zagalak, B.,; Zickler, J.,; Zovyte, V. F.,
• HerausgeberIn: European Symposium on Vitamin B 12 and Intrinsic Factor ‹3, 1979, Zürich›,; Friedrich, W.,; Universität ‹Zürich›, ,; Zagalak, B.,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2019]; ©1979
• Year of Publication: 2019
• Edition: Reprint 2019
• Language: English
• Physical Description: 1 online resource (1212 p.) :; Num. figs.

Table of Contents

Frontmatter -- Preface -- CONTENTS -- Chapter 1. CHEMISTRY OF CORRINOIDS. TOTAL SYNTHESIS OF VITAMIN B12 -- Introductory remarks for opening of 3rd European Symposium on vitamin B12 -- Introductory remarks. Historical perspectives on the isolation of crystalline vitamin B12 -- New and old problems in the structure analysis of vitamin B12 -- Synthetic vitamin B12 -- Chemical synthesis of corrinoids: current problems and recent advances -- Recent studies on the synthesis of vitamin B12 -- New reactions of the chromophoric system of vitamin B12 derivatives -- Structure and reactivity of the so-called stable yellow corrinoids -- Concerning the structure of so-called yellow products obtained from naturally occurring metal-free corrinoids -- Correlation of vitamin B12 methanolysis products with cobyrinic methyl ester amides prepared from hydrogenobyrinic acid amides -- Preparation and X-ray structural analyses of a cobyrinic acid diamide and the corresponding rhodium analogue -- Concerning a new corrinoid from municipal sludge -- Steric course of the substitution by vitamin B12s as studied by 1H-NMR spectroscopy -- Synthesis and X-ray analysis of a porphyrin-type Co(I)-complex -- Stereochemistry of the formation and cleavage of the Co-C bond in a vitamin B12 model -- The structure of superoxocobalamin, a single crystal ESR study -- NMR studies of a novel form of vitamin B12 -- Circular dichroism study of organocobalamins -- Concerning electronic, CD and ORD spectra of isomeric pairs of several (Co-methyl)-corrinoids -- Some properties of cobalaminhexacyanoferrate -- Temperature-jump kinetics of the "base-on" - "base-off" equilibrium of methylcobalamin -- Electrochemistry of vitamin B12. Equilibria, kinetics and mechanisms in the B12a - B12r - B12s oxido-reduction -- Electrochemistry of vitamin B12. Alkyl cobalamins and cobinamides -- Chapter 2. BIOSYNTHESIS OF CORRINOIDS -- Recent biosynthetic researches on vitamin B12 -- Intermediary metabolism of cobyrinic acid biosynthesis -- On the methylation process in cobyrinic acid biosynthesis -- Biogenesis of tetrapyrrole compounds (porphyrins and corrinoids), and its regulation -- Factor I ex Clostridium tetanomorphum: proof of structure and relationship to vitamin B12 biosynthesis -- On the biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B12 -- The enzyme system of propionic acid bacteria transforming riboflavin into 5,6-dimethylbenzimidazole -- Straight approaches to the nucleotide loop -- Ribosomal proteins share in vitamin B12 biosynthesis -- The ribosomal proteins L2, L5, L18 and L25 involved in vitamin B12 biosynthesis -- Formation and role of vitamin B12 in Protaminobacter ruber and Rhizobium meliloti -- Chapter 3. CORRINOID DEPENDENT ENZYMES AND REACTIONS. MODEL SYSTEMS -- Current status of the mechanism of action of B12 - coenzyme -- A stereochemical approach to the diol dehydratase reaction -- Coenzyme B12-dependent diol dehydratase - distribution and metabolic role in Enterobacteriaceae, enzymological properties and interaction with coenzyme B12 -- Adenosylcobalamin-dependent glycerol dehydratase interaction with substrates and their analogs -- Glycerol dehydratase from Aerobacter aerogenes -- The mechanism of action of methylmalonyl-CoA mutase as studied with isotope labelling and synthetic models -- Recent studies on the mechanism of action of ethanolamine ammonia-lyase -- Studies on the mechanism of reactions catalysed by ethanolamine ammonia-lyase -- Steric course of the ethanolamine-ammonia lyase reaction -- The chemical synthesis and coenzymatic properties of analogs of adenosylcobalamin in the ribonucleotide reductase reaction -- Review of the EPR of B12r and B12 -dependent enzyme reactions -- Vitamin B12: current problems and recent advances -- The role of corrinoids in the total synthesis of acetate from C02 -- Mechanisms for B12 -dependent methylation -- Nonenzymic models for the enigmatic coenzyme B12-dependent carbon-skeleton rearrangements -- The mechanism of action of coenzyme B12 -- Model systems for adenosylcobalamin dependent enzymic reactions -- Bridged cobaloximes as vitamin B12 models -- Modified adenosylaobalamin: model systems for the active sites of corrinoid-dependent enzymes -- Chapter 4. ANALOGUES AND ANTAGONISTS OF VITAMIN B12 -- Naturally occurring vitamin B12 antagonists and their potential therapeutic value -- Structures of some vitamin B12 analogues and their biological as well as biochemical functions -- Novel metal-free corrinoids and metal analogues -- Preparation of ferribalamin, the Fe(III)-analogue of vitamin B12 -- Chapter 5. VITAMIN B12 ASSAY -- Vitamin B12 assay: an evaluation of radiodilution assay using cobinamide to increase specificity -- Effect of residual extract products and the type of binders (R or IF) on serum vitamin B12 levels by radioisotope dilution assay -- Differential assay of cobamides in serum using R-protein radioisotopic dilution assay, E.coli and E.gracilis assays -- Rapid determination of corrinoids by high performance liquid chromatography -- Determination of the plasma cobalamins by one-dimensional thin-layer chromatography -- Chemical quantitation of corrinoids -- Enzymatic estimation of vitamin B12 -- Essential prerequisites for the analysis of cyanocobalamin in biochemically complex samples using radiometric competitive binding assays -- Chapter 6. ABSORPTION, TRANSPORT AND DISTRIBUTION OF VITAMIN B12 -- Distribution of cobalamins in the animal body -- Vitamin B12 in membrane mimetic agents - theoretical considerations and practical applications -- Transport of vitamin B12 in Escherichia coli -- The plasma transport of cobalamin (Cbl) -- Soluble and membrane-bound vitamin B12 transport proteins -- The origin and clinical implications of vitamin B12 binders - the transcobalamins -- Large vitamin B12-binding proteins and complexes in human serum -- Heterogeneity of antibodies against B12 binders in pernicious anaemia -- The intraluminal phase of vitamin B12 transport in humans -- Polymorphic variants of transcobalamin II rare alleles in family studies -- Relationship between cobalophilin releasing and functional state of polymorphonuclear granulocytes -- The significance of vitamin B12 binders in the central nervous system -- In vitro acid dissociation of cobalamin-transcobalamin II complexes formed in vivo: a probe in the study of TC II-kinetics -- Calcium dependencies in the binding of transcobalamins to subcellular particles of liver cells -- The effect of antibiotics on transcobalamin II synthesis in rabbit liver cell culture -- Solubilization and characterization of the transcobalamin II acceptor from human placenta and rabbit liver -- Strength of binding of methyl-, 5 '-deoxyadenosyl-, cyano- and hydroxocobalamin to human transcobalamin I and II and intrinsic factor -- Adsorptive endocytosis of transcobalamin II-vitamin B12 by isolated rat liver parenchymal cells -- Species specificity between TC II, TC II-Cbl uptake and anti-TC II -- Transcobalamin II polymorphism in african populations -- Transcobalamins during induction of nutritional cobalamin deficiency in the fruit bat -- Heterogeneity of transcobalamin II demonstrated by isoelectric focusing in urea -- Radioimmunosorbent determinations of unsaturated and total transcobalamin II in human serum -- The "dU suppression test" and "thymidine suppression test": evidence for reciprocal relationship between the "de novo" and "salvage" pathways of DNA synthesis -- TC II deficiency: observations with deoxyuridine suppression test -- Spectral studies on hog intrinsic factor and hog non-intrinsic factor -- Amino terminal sequence of hog non-intrinsic factor and hog intrinsic factor -- Subunit structure of the pig ileal intrinsic factor receptor -- Cobinamide blocking assay for intrinsic factor -- Intracelular transport of vitamin B12 in enterocytes -- Evidence for the chief cell as the source of intrinsic factor secretion in the rat -- Long-term treatment of pernicious anemia patients with intrinsic factor -- An analogy of cobalamin membrane transport: an intestinal receptor for heme -- A simplified method for quantitative determination of vitamin B12 absorption -- Vitamin B12 absorption studies with plastic whole body counter in

patients with gastroenterological operation -- Affinity photo-release purification of cobalamin-binding proteins -- Effect of pentagastrin in vitamin B12 absorption in the guinea pig -- Synthesis of cobalamin coenzymes in the rat and their secretion from the liver into plasma and bile -- The pattern of cobalamins in human erythrocytes -- Presence of sulfitocobalamin in cell extracts. Resolution and identification by SP-Sephadex C-25 cation exchange chromatography -- Mitochondrial cobalamins: types, sources, and functions with evidence of their noninvolvement in mitochondrial DNA synthesis -- Chapter 7. PHYSIOLOGY AND PATHOLOGY OF VITAMIN B12 -- Studies on vitamin B12 and ubiquinone -- Haematological aspects of cobalamin deficiency -- The neurology of vitamin B12 deficiency -- Clinioal diseases related to defioienoies of vitamin B12 transport proteins -- Effects of methylaobalamin on peripheral neuropathies or experimentally-induced neuropathies -- Inherited deficiencies of the deoxyadenosylcobalamin (Ado-Cbl) dependent L-methylmalonyl-CoA mutase system: clinical and biochemical aspects -- An investigation of a possible role for coenzyme B12 in ribonucleotide reduction in rabbit bone marrow -- Participation of cAMP in regulation of coenzyme B12 dependent glycerol dehydratase synthesis from Klebsiella pneumoniae ATCC 85955 -- Carbon monoxide oxidation by Clostridia: evidence for the involvement of a corrinoid-like compound -- The in vivo effects of nitrous oxide on human bone marrow - a morphological, biochemical and cell cycle study -- Interconversion of cobalamins in human lymphocytes in vitro and the influence of nitrous oxide on synthesis of cobalamin coenzymes -- Studies on cobalamin and folate metabolism in rats exposed to nitrous oxide (N2O) -- Alterations in mammalian cells induced by inactivation of vitamin B12 with nitrous oxide -- High ascorbic acid intake and vitamin B12 status in the rat -- Ability of megadoses of vitamin C to destroy vitamin B12 and cobinamide and to reduce absorption of vitamin B12 (with a note on B12 radioassays) -- Interaction between methylcobalamin and some amino acids in single cell proteins -- Methylcobalamin and the modification of proteins in vitro -- Deoxyadenosylcobalamin and the process of methylation of tRNA in model systems -- The participation of coenzyme B12 in the synthesis of DNA by Propionibacterium shermanii -- Recent advances in cobalamin metabolism: abnormalities in coenzyme distribution in tumor development and in inherited metabolic disease -- On some properties of the effect and metabolism of different cobalamins in tumor-bearing rats -- Gastric cancer as a risk factor in pernicious anaemia -- Interference with cobalamin metabolism and tumour growth by an analogue of methylcobalamin -- Vitamin B12 requirement for replication of mouse leukemia L1210 cells: functional relevance to folate metabolism -- Vitamin B12 and folia acid interrelations: a new look -- The effect of hypothyroidism on histidine oxidation and folate-dependent enzyme levels -- Cobalamin-dependent methionine synthesis and the regulation of the metabolism of activated folic acid derivatives in cultured human lymphoblasts -- Author and Citation Index -- Subject Index -- Collection of Photographs from the Symposium