Peptide Antibiotics Biosynthesis and Functions : : Enzymatic Formation of Bioactive Peptidesand Related Compounds / / ed. by Hans von Döhren, Horst Kleinkauf.
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Table of Contents:
- Frontmatter
- Preface
- Foreword
- Contents
- I. Introduction
- A Survey of Enzymatic Peptide Formation
- On Biosynthesis of the Cyclic Antibiotics Gramicidin S and Tyrocidine, and of Linear Gramicidin
- II. Pathways and Genetics
- Chemistry and Biosynthesis of the Poly (y-D-Glutamyl) Capsule in Bacillus licheniformis
- Recent Developments with Cell free Extracts on the Enzymic Biosynthesis of Penicillins and Cephalosporins
- Accumulation of <5-(L-a-Aminoadipyl)-L-Cysteinyl-D-Valine Derivatives by Mutants of Cephalosporium acremonium
- Genetic Studies on the Biosynthesis of Actinomycin
- Role of Peptides from Mycobacillin-Synthesizing System in the Biosynthesis of Mycobacillin
- III. Fermentations and Peptide Production
- Environmental Influences on the Dynamics of the Gramicidin S Fermentation
- Production of Gramicidin S-Synthetase from Bacillus brevis ATCC 9999 by Batch Fermentation
- Studies on the Gramicidin S-Synthetase Production in Bacillus brevis ATCC 9999 in C- and P-Limited Chemostat Cultures
- On the Role of L-Leucine in the Control of Bacitracin Formation by Bacillus licheniformis
- Current Research in Ergot Peptide Synthesis by Claviceps purpurea
- Applications of Multienzyme Systems in the Production of Peptide Antibiotics
- IV. Enzyme Systems
- The Fidelity of Gramicidin S-Synthetase with Particular Reference to the Amino Acids Cyclohexylalanine and Phenylalanine
- Some Characteristics of Gramicidin S-Synthetase Obtained from Mutants of Bacillus brevis which could not form DPhenylalanyl- L-Prolyl Diketo-Piperazine
- Kinetics of Amino Acid Activation in Gramicidin S Synthesis
- The Temperature Dependence of the Partial Processes Involved in the Biosynthesis of Gramicidin S
- Further Characterization of Multienzyme Fragments of Gramicidin S Synthetase obtained from Gramicidin S Nonproducer Mutants
- Limited Proteolysis: Studies on the Multienzyme GS2 of Gramicidin S-Synthetase
- Tryptic Cleavage of the Heavy Enzyme of Gramicidin SSynthetase
- Use of Affinity Chromatography in Purification of Gramicidin S-Synthetases
- A Survey on the Use of Affinity Chromatography for Studying the Mechanism of Gramicidin S Formation
- Other Synthetases
- Enniatin-Synthetase: Studies on the Activation of Residues Involved in Enniatin Synthesis
- Biosynthesis of Antibiotic Peptides Polymyxin E and Gramicidin A
- Component I Protein of Bacitracin Synthetase: A Multifunctional Protein
- Bacitracin Synthetase Subenzymes and Tail Peptide Formation in Bacitracin
- Bacitracin Synthetase. Tryptic Cleavage of Enzymes B and C
- Edeine Synthetase: Evidence for Bidirectional Synthesis of Edeines
- Biosynthesis of Leupeptin
- Biosynthesis of Carnosine and Related Peptides
- Inhibition of Carnosine Synthetase by Spermidine
- Corynebacterium species Folylpoly-y-Glutamate Synthetase
- Discussion Peptide Synthetases - Problems and Properties Summary of a round-table discussion held on Sept. 5th, 1980
- V. Possible Functions of Peptide Antibiotics in their Producer Organisms
- A Survey of Possible Functions of Peptide Antibiotics in the Producer Organisms
- Tyrocidine Induced Sporulation of Bacillus brevis in a Medium Lacking A Nitrogen Source
- Studies on the Role of Gramicidin S in the Life Cycle of its Producer Bacillus brevis ATCC 9999
- Investigations on the Function of Amatoxins in Amanita Species: A Case for Amatoxins as Potential Regulators of Transcription
- Structural Requirements for the Biological Activity of Polymyxin B
- Gramicidin S - Fragments Generated by Mild Acid Hydrolysis of the Antibiotic
- Relevance of the Association of Polymyxin Biosynthetic Complex with Membrane DNA During Growth and Sporulation of B. polymyxa
- Author Index
- Subject Index
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