Peptide Antibiotics Biosynthesis and Functions : : Enzymatic Formation of Bioactive Peptidesand Related Compounds / / ed. by Hans von Döhren, Horst Kleinkauf.
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| Other title: | Frontmatter -- Preface -- Foreword -- Contents -- I. Introduction -- A Survey of Enzymatic Peptide Formation -- On Biosynthesis of the Cyclic Antibiotics Gramicidin S and Tyrocidine, and of Linear Gramicidin -- II. Pathways and Genetics -- Chemistry and Biosynthesis of the Poly (y-D-Glutamyl) Capsule in Bacillus licheniformis -- Recent Developments with Cell free Extracts on the Enzymic Biosynthesis of Penicillins and Cephalosporins -- Accumulation of <5-(L-a-Aminoadipyl)-L-Cysteinyl-D-Valine Derivatives by Mutants of Cephalosporium acremonium -- Genetic Studies on the Biosynthesis of Actinomycin -- Role of Peptides from Mycobacillin-Synthesizing System in the Biosynthesis of Mycobacillin -- III. Fermentations and Peptide Production -- Environmental Influences on the Dynamics of the Gramicidin S Fermentation -- Production of Gramicidin S-Synthetase from Bacillus brevis ATCC 9999 by Batch Fermentation -- Studies on the Gramicidin S-Synthetase Production in Bacillus brevis ATCC 9999 in C- and P-Limited Chemostat Cultures -- On the Role of L-Leucine in the Control of Bacitracin Formation by Bacillus licheniformis -- Current Research in Ergot Peptide Synthesis by Claviceps purpurea -- Applications of Multienzyme Systems in the Production of Peptide Antibiotics -- IV. Enzyme Systems -- The Fidelity of Gramicidin S-Synthetase with Particular Reference to the Amino Acids Cyclohexylalanine and Phenylalanine -- Some Characteristics of Gramicidin S-Synthetase Obtained from Mutants of Bacillus brevis which could not form DPhenylalanyl- L-Prolyl Diketo-Piperazine -- Kinetics of Amino Acid Activation in Gramicidin S Synthesis -- The Temperature Dependence of the Partial Processes Involved in the Biosynthesis of Gramicidin S -- Further Characterization of Multienzyme Fragments of Gramicidin S Synthetase obtained from Gramicidin S Nonproducer Mutants -- Limited Proteolysis: Studies on the Multienzyme GS2 of Gramicidin S-Synthetase -- Tryptic Cleavage of the Heavy Enzyme of Gramicidin SSynthetase -- Use of Affinity Chromatography in Purification of Gramicidin S-Synthetases -- A Survey on the Use of Affinity Chromatography for Studying the Mechanism of Gramicidin S Formation -- Other Synthetases -- Enniatin-Synthetase: Studies on the Activation of Residues Involved in Enniatin Synthesis -- Biosynthesis of Antibiotic Peptides Polymyxin E and Gramicidin A -- Component I Protein of Bacitracin Synthetase: A Multifunctional Protein -- Bacitracin Synthetase Subenzymes and Tail Peptide Formation in Bacitracin -- Bacitracin Synthetase. Tryptic Cleavage of Enzymes B and C -- Edeine Synthetase: Evidence for Bidirectional Synthesis of Edeines -- Biosynthesis of Leupeptin -- Biosynthesis of Carnosine and Related Peptides -- Inhibition of Carnosine Synthetase by Spermidine -- Corynebacterium species Folylpoly-y-Glutamate Synthetase -- Discussion Peptide Synthetases - Problems and Properties Summary of a round-table discussion held on Sept. 5th, 1980 -- V. Possible Functions of Peptide Antibiotics in their Producer Organisms -- A Survey of Possible Functions of Peptide Antibiotics in the Producer Organisms -- Tyrocidine Induced Sporulation of Bacillus brevis in a Medium Lacking A Nitrogen Source -- Studies on the Role of Gramicidin S in the Life Cycle of its Producer Bacillus brevis ATCC 9999 -- Investigations on the Function of Amatoxins in Amanita Species: A Case for Amatoxins as Potential Regulators of Transcription -- Structural Requirements for the Biological Activity of Polymyxin B -- Gramicidin S - Fragments Generated by Mild Acid Hydrolysis of the Antibiotic -- Relevance of the Association of Polymyxin Biosynthetic Complex with Membrane DNA During Growth and Sporulation of B. polymyxa -- Author Index -- Subject Index |
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| Format: | Mode of access: Internet via World Wide Web. |
| ISBN: | 9783110837834 9783110637342 |
| DOI: | 10.1515/9783110837834 |
| Access: | restricted access |
| Hierarchical level: | Monograph |
| Statement of Responsibility: | ed. by Hans von Döhren, Horst Kleinkauf. |
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