Peptide Antibiotics Biosynthesis and Functions : : Enzymatic Formation of Bioactive Peptidesand Related Compounds / / ed. by Hans von Döhren, Horst Kleinkauf.

• Superior document: Title is part of eBook package: De Gruyter DGBA Reference Works <1990
• MitwirkendeR: Aarstad, Kjell,; Akashi, Katsuhiko,; Altmann, Michael,; Aust, Hans Jürgen,; Bauer, Karl,; Bernhard, Thomas,; Bose, Susil Kumar,; Bothe, Dagmar,; Chandrasekaran, G. N.,; Chiu, Chung-Wai,; Christiansen, Cath.,; Danders, Wolf,; De Buyser, Dirk,; De Visscher, Patrick,; Dellweg, Hans Werner,; Demain, Arnold L.,; Döhren, H. v.,; Döhren, Hans von,; Ebert, Marion,; El-Samaraie, Ali,; Elander, Richard P.,; Frøyshov, Øystein,; Gerhardt, Sabine,; Haavik, Hans Ivar,; Haeselbarth, Gisela,; Heaney-Kieras, Joy,; Hook, Derek J.,; Hori, Makoto,; Ishihara, Hiroaki,; Jayaraman, Kunthala,; Johnson, Billy E. C.,; Jungblut, Peter,; Kaur, N. Satwant,; Keller, Ullrich,; Kittelberger, Reinhold,; Kleinkauf, Horst,; Komura, Sadaaki,; Kraepelin, Gunda,; Krause, Michael,; Kurahashi, Kiyoshi,; Kurylo-Borowska, Zofia,; Laland, Søren G.,; Leyman, Dirk,; Lipmann, Fritz,; Little, Michael,; Mallow, Norbert,; Marahiel, Mohamed A.,; Marshall, Finley D.,; Mathiesen, Anita,; Morin, Robert B.,; Mullersman, Jerald E.,; Nimi, Osamu,; Nishio, Chika,; Nordvi, Berit,; Ogawa, Ikuzo,; Paulus, Henry,; Pfaender, Peter,; Poirier, Agnès,; Pore, Mrinalini S.,; Preston, James F.,; Radhakrishna, G.,; Ramachandran, L. K.,; Ristow, Hansjürgen,; Romeo, Tony,; Russo, Joseph,; Rönspeck, Wolfgang,; Saito, Yoshitaka,; Salnikow, Johann,; Schröter, Christa,; Seely, James E.,; Sengupta, Subhabrata,; Shane, Barry,; Shimura, Kensuke,; Shirafuji, Hideo,; Spriet, Jan,; Srinivasa, B. R.,; Stark, Henry J.,; Stochaj, Eleanor,; Suzukake, Kayoko,; Troy, Frederic A.,; Umezawa, Hidemi Hayashi Hamao,; Vandamme, Erick J.,; Vansteenkiste, Ghislain C.,; Vasantha, N.,; Vater, Joachim,; Vitkovic, Ljubisa,; Yoneda, Masahiko,; Zimmer, Trine-Lise,; Zocher, Rainer,; Zschiedrich, Harald,
• HerausgeberIn: Döhren, Hans von,; Kleinkauf, Horst,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2023]; ©1982
• Year of Publication: 2023
• Edition: Reprint 2019
• Language: English
• Physical Description: 1 online resource (XI, 479 p.) :; Num. figs. and tables

Table of Contents

Frontmatter -- Preface -- Foreword -- Contents -- I. Introduction -- A Survey of Enzymatic Peptide Formation -- On Biosynthesis of the Cyclic Antibiotics Gramicidin S and Tyrocidine, and of Linear Gramicidin -- II. Pathways and Genetics -- Chemistry and Biosynthesis of the Poly (y-D-Glutamyl) Capsule in Bacillus licheniformis -- Recent Developments with Cell free Extracts on the Enzymic Biosynthesis of Penicillins and Cephalosporins -- Accumulation of <5-(L-a-Aminoadipyl)-L-Cysteinyl-D-Valine Derivatives by Mutants of Cephalosporium acremonium -- Genetic Studies on the Biosynthesis of Actinomycin -- Role of Peptides from Mycobacillin-Synthesizing System in the Biosynthesis of Mycobacillin -- III. Fermentations and Peptide Production -- Environmental Influences on the Dynamics of the Gramicidin S Fermentation -- Production of Gramicidin S-Synthetase from Bacillus brevis ATCC 9999 by Batch Fermentation -- Studies on the Gramicidin S-Synthetase Production in Bacillus brevis ATCC 9999 in C- and P-Limited Chemostat Cultures -- On the Role of L-Leucine in the Control of Bacitracin Formation by Bacillus licheniformis -- Current Research in Ergot Peptide Synthesis by Claviceps purpurea -- Applications of Multienzyme Systems in the Production of Peptide Antibiotics -- IV. Enzyme Systems -- The Fidelity of Gramicidin S-Synthetase with Particular Reference to the Amino Acids Cyclohexylalanine and Phenylalanine -- Some Characteristics of Gramicidin S-Synthetase Obtained from Mutants of Bacillus brevis which could not form DPhenylalanyl- L-Prolyl Diketo-Piperazine -- Kinetics of Amino Acid Activation in Gramicidin S Synthesis -- The Temperature Dependence of the Partial Processes Involved in the Biosynthesis of Gramicidin S -- Further Characterization of Multienzyme Fragments of Gramicidin S Synthetase obtained from Gramicidin S Nonproducer Mutants -- Limited Proteolysis: Studies on the Multienzyme GS2 of Gramicidin S-Synthetase -- Tryptic Cleavage of the Heavy Enzyme of Gramicidin SSynthetase -- Use of Affinity Chromatography in Purification of Gramicidin S-Synthetases -- A Survey on the Use of Affinity Chromatography for Studying the Mechanism of Gramicidin S Formation -- Other Synthetases -- Enniatin-Synthetase: Studies on the Activation of Residues Involved in Enniatin Synthesis -- Biosynthesis of Antibiotic Peptides Polymyxin E and Gramicidin A -- Component I Protein of Bacitracin Synthetase: A Multifunctional Protein -- Bacitracin Synthetase Subenzymes and Tail Peptide Formation in Bacitracin -- Bacitracin Synthetase. Tryptic Cleavage of Enzymes B and C -- Edeine Synthetase: Evidence for Bidirectional Synthesis of Edeines -- Biosynthesis of Leupeptin -- Biosynthesis of Carnosine and Related Peptides -- Inhibition of Carnosine Synthetase by Spermidine -- Corynebacterium species Folylpoly-y-Glutamate Synthetase -- Discussion Peptide Synthetases - Problems and Properties Summary of a round-table discussion held on Sept. 5th, 1980 -- V. Possible Functions of Peptide Antibiotics in their Producer Organisms -- A Survey of Possible Functions of Peptide Antibiotics in the Producer Organisms -- Tyrocidine Induced Sporulation of Bacillus brevis in a Medium Lacking A Nitrogen Source -- Studies on the Role of Gramicidin S in the Life Cycle of its Producer Bacillus brevis ATCC 9999 -- Investigations on the Function of Amatoxins in Amanita Species: A Case for Amatoxins as Potential Regulators of Transcription -- Structural Requirements for the Biological Activity of Polymyxin B -- Gramicidin S - Fragments Generated by Mild Acid Hydrolysis of the Antibiotic -- Relevance of the Association of Polymyxin Biosynthetic Complex with Membrane DNA During Growth and Sporulation of B. polymyxa -- Author Index -- Subject Index