Chemistry of Nucleic Acids / / Harri Lönnberg.

• Superior document: Title is part of eBook package: De Gruyter DG Ebook Package English 2020
• VerfasserIn: Lönnberg, Harri,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2020]; ©2020
• Year of Publication: 2020
• Language: English
• Series: De Gruyter Textbook
• Physical Description: 1 online resource (XI, 353 p.)
• Other title: Frontmatter --; Preface --; Contents --; 1 Nucleosides: structure, nomenclature and solution equilibria --; 2 Nucleosides: synthesis, reactions and use in chemotherapy --; 3 Nucleotides --; 4 Oligonucleotides: synthesis --; 5 Oligonucleotides: reactions of phosphodiester linkages --; 6 Oligonucleotide conjugates --; 7 Nucleic acids --; 8 Catalytic nucleic acids --; 9 Nucleic acids as drugs and drug targets 1: antisense, splice-switching, triplex-forming and immune-stimulatory oligonucleotides --; 10 Nucleic acids as drugs and drug targets 2: RNA interference, 2′,5′-oligoadenylates and riboswitches --; 11 Nucleic acids as drugs and drug targets 3: target recognition and delivery --; Abbreviations --; Index
• Format: Mode of access: Internet via World Wide Web.
• ISBN: 9783110609295; 9783110696288; 9783110696271; 9783110659061; 9783110704716; 9783110704518; 9783110704754; 9783110704556
• DOI: 10.1515/9783110609295
• Access: restricted access
• Hierarchical level: Monograph
• Statement of Responsibility: Harri Lönnberg.

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.