Hepatobiliary Transport in Health and Disease / / ed. by Dieter Häussinger, Ralf Kubitz, Verena Keitel.

• Superior document: Title is part of eBook package: De Gruyter DGBA Backlist Complete English Language 2000-2014 PART1
• MitwirkendeR: Baghdasaryan, Anna,; Beuers, Ulrich,; Bode, Johannes,; Claudel, Thierry,; Ellinger, Philipp,; Fabris, Luca,; Gadaleta, Raffaella,; Graf, Dirk,; Herebian, Diran,; Hohenester, Simon,; Hov, Johannes Roksund,; Häussinger, Dieter,; Karlsen, Tom Hemming,; Keitel, Verena,; Keppler, Dietrich,; Kluth, Marianne,; Kubitz, Ralf,; Lammert, Frank,; Mayatepek, Ertan,; Meier, Peter J.,; Moschetta, Antonio,; Müllenbach, Roman,; Pauli-Magnus, Christiane,; Przybylla, Susanne,; Raizner, Aileen,; Reinehr, Roland,; Schmitt, Lutz,; Schrumpf, Erik,; Smits, Sander H. J.,; Stieger, Bruno,; Strazzabosco, Mario,; Trauner, Michael,; Wittenburg, Henning,
• HerausgeberIn: Häussinger, Dieter,; Keitel, Verena,; Kubitz, Ralf,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2012]; ©2012
• Year of Publication: 2012
• Language: English
• Physical Description: 1 online resource (292 p.)

One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians.

Table of Contents

Frontmatter -- Preface -- List of Contributors -- Contents -- Abbreviations -- 1 Physiology of bile formation: Hepatocellular bile salt transporters -- 2 Structure and function of hepatic ABC transporters -- 3 Short- and long-term regulation of hepatobiliary transport -- 4 Nuclear bile acid receptor FXR and hepatobiliary transport systems -- 5 Bile acid signaling in the liver and the biliary tree -- 6 Modulation of innate immunity and inflammation by bile acids and their receptors -- 7 Bile acids as extrahepatic and interorgan signaling molecules -- 8 Disorders of bile duct development -- 9 Mutations of the bile salt export pump (BSEP) and multidrug-resistance protein 3 (MDR3) -- 10 MRP2 (ABCC2) and disorders of bilirubin handling in liver -- 11 Hepatobiliary transport during pregnancy: Crosstalk between transporters and hormones -- 12 Hepatobiliary transport and gallstone formation -- 13 Molecular basis of primary biliary cirrhosis -- 14 The molecular basis of primary sclerosing cholangitis -- 15 Drug-induced cholestatic liver injury -- 16 Bile acids and receptors: Therapeutic relevance -- 17 Analysis of bile acids by tandem mass spectrometry -- Index