Applications of toxicogenomics in safety evaluation and risk assessment / edited by Darrell R. Boverhof, B. Bhaskar Gollapudi.
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| Year of Publication: | 2011 |
| Language: | English |
| Online Access: | |
| Physical Description: | xiii, 377 p., [8] p. of plates :; ill. (some col.) |
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Table of Contents:
- Toxicology, "omics" technologies, and toxicogenomics : a primer
- Introduction to human health risk assessment
- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward
- Approaches and practical considerations for the analysis of toxicogenomics data
- Genomics in identifying mutagenic mode of action in carcinogenesis
- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens
- Genomics in characterizing endocrine toxicity
- Studying organ specific toxicity using gene expression profiling
- Toxicogenomic studies in human populations
- Toxicogenomics applied to ecological risk assessment
- Analysis of transcriptomic dose response data for toxicology and risk assessment
- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges
- Toxicogenomics and animal alternatives
- Toxicogenomics and the regulatory framework
- Standardization of gene expression information for the safety evaluation--activities in Japan -
- Applying transcriptional profiling in drug safety evaluation
- Reframing the risk assessment paradigm : towards a systems biology approach.