Applications of toxicogenomics in safety evaluation and risk assessment / edited by Darrell R. Boverhof, B. Bhaskar Gollapudi.

• Author: ProQuest (Firm)
• TeilnehmendeR: Boverhof, Darrell R.; Gollapudi, B. Bhaskar.; ProQuest (Firm)
• Year of Publication: 2011
• Language: English
• Physical Description: xiii, 377 p., [8] p. of plates :; ill. (some col.)

Table of Contents

Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan - -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach.