In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark.

• Superior document: Wissenschaftliche Reihe der Klinik für Pferde ; v.51
• Author: Weber, Lisa Annabel.
• Place / Publishing House: Göttingen : : Cuvillier Verlag,, 2021.; {copy}2021.
• Year of Publication: 2021
• Edition: 1st ed.
• Language: English
• Series: Wissenschaftliche Reihe der Klinik für Pferde
• Physical Description: 1 online resource (141 pages)

Table of Contents

• Intro
• LIST OF ABBREVIATIONS
• SUMMARY
• ZUSAMMENFASSUNG
• 1. Introduction
• 1.1. The equine malignant melanoma
• 1.2. The equine sarcoid: an overview
• 1.3. Topical drug application
• 1.4. Naturally occurring substances in plane bark and their syntheticallymodified derivatives
• 1.5. Hypotheses and aims of the thesis
• 2. Manuscript I:Betulinic acid shows anticancer activity against equine melanoma cells andpermeates isolated equine skin in vitro
• 2.1. Supplemental data
• 3. Manuscript II:In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate asa topical treatment for equine skin cancer
• 4. Manuscript III:Concentration profiles and safety of topically applied betulinic acid andNVX-207 in eight healthy horses - A randomized, blinded, placebocontrolled,crossover pilot study
• 5. Manuscript IV:Effects of topically applied betulinic acid and NVX-207 on early stageequine melanoma - A prospective, randomized, double-blind, placebocontrolledpilot study
• 6. General discussion
• 6.1. Summarized findings
• 6.2. Interpretation of the findings
• 7. Major findings and conclusions
• 8. Future perspectives
• 9. References
• Affidavit
• Acknowledgements.