In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark.
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Superior document: | Wissenschaftliche Reihe der Klinik für Pferde ; v.51 |
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Place / Publishing House: | Göttingen : : Cuvillier Verlag,, 2021. {copy}2021. |
Year of Publication: | 2021 |
Edition: | 1st ed. |
Language: | English |
Series: | Wissenschaftliche Reihe der Klinik für Pferde
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Online Access: | |
Physical Description: | 1 online resource (141 pages) |
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082 | 0 | |a 636.1089 | |
100 | 1 | |a Weber, Lisa Annabel. | |
245 | 1 | 0 | |a In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark. |
250 | |a 1st ed. | ||
264 | 1 | |a Göttingen : |b Cuvillier Verlag, |c 2021. | |
264 | 4 | |c {copy}2021. | |
300 | |a 1 online resource (141 pages) | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
490 | 1 | |a Wissenschaftliche Reihe der Klinik für Pferde ; |v v.51 | |
505 | 0 | |a Intro -- LIST OF ABBREVIATIONS -- SUMMARY -- ZUSAMMENFASSUNG -- 1. Introduction -- 1.1. The equine malignant melanoma -- 1.2. The equine sarcoid: an overview -- 1.3. Topical drug application -- 1.4. Naturally occurring substances in plane bark and their syntheticallymodified derivatives -- 1.5. Hypotheses and aims of the thesis -- 2. Manuscript I:Betulinic acid shows anticancer activity against equine melanoma cells andpermeates isolated equine skin in vitro -- 2.1. Supplemental data -- 3. Manuscript II:In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate asa topical treatment for equine skin cancer -- 4. Manuscript III:Concentration profiles and safety of topically applied betulinic acid andNVX-207 in eight healthy horses - A randomized, blinded, placebocontrolled,crossover pilot study -- 5. Manuscript IV:Effects of topically applied betulinic acid and NVX-207 on early stageequine melanoma - A prospective, randomized, double-blind, placebocontrolledpilot study -- 6. General discussion -- 6.1. Summarized findings -- 6.2. Interpretation of the findings -- 7. Major findings and conclusions -- 8. Future perspectives -- 9. References -- Affidavit -- Acknowledgements. | |
588 | |a Description based on publisher supplied metadata and other sources. | ||
590 | |a Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. | ||
650 | 0 | |a Skin--Cancer. | |
655 | 4 | |a Electronic books. | |
776 | 0 | 8 | |i Print version: |a Weber, Lisa Annabel |t In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark |d Göttingen : Cuvillier Verlag,c2021 |z 9783736974326 |
797 | 2 | |a ProQuest (Firm) | |
830 | 0 | |a Wissenschaftliche Reihe der Klinik für Pferde | |
856 | 4 | 0 | |u https://ebookcentral.proquest.com/lib/oeawat/detail.action?docID=6636881 |z Click to View |