In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark.

• Superior document: Wissenschaftliche Reihe der Klinik für Pferde ; v.51
• Author: Weber, Lisa Annabel.
• Place / Publishing House: Göttingen : : Cuvillier Verlag,, 2021.; {copy}2021.
• Year of Publication: 2021
• Edition: 1st ed.
• Language: English
• Series: Wissenschaftliche Reihe der Klinik für Pferde
• Physical Description: 1 online resource (141 pages)

Table of Contents

Intro -- LIST OF ABBREVIATIONS -- SUMMARY -- ZUSAMMENFASSUNG -- 1. Introduction -- 1.1. The equine malignant melanoma -- 1.2. The equine sarcoid: an overview -- 1.3. Topical drug application -- 1.4. Naturally occurring substances in plane bark and their syntheticallymodified derivatives -- 1.5. Hypotheses and aims of the thesis -- 2. Manuscript I:Betulinic acid shows anticancer activity against equine melanoma cells andpermeates isolated equine skin in vitro -- 2.1. Supplemental data -- 3. Manuscript II:In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate asa topical treatment for equine skin cancer -- 4. Manuscript III:Concentration profiles and safety of topically applied betulinic acid andNVX-207 in eight healthy horses - A randomized, blinded, placebocontrolled,crossover pilot study -- 5. Manuscript IV:Effects of topically applied betulinic acid and NVX-207 on early stageequine melanoma - A prospective, randomized, double-blind, placebocontrolledpilot study -- 6. General discussion -- 6.1. Summarized findings -- 6.2. Interpretation of the findings -- 7. Major findings and conclusions -- 8. Future perspectives -- 9. References -- Affidavit -- Acknowledgements.