Chagas Disease : : from cellular and molecular aspects of trypanosoma cruzi-host interactions to the clinical intervention / / edited by Rubem Menna-Barreto.
Even 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial cha...
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| Place / Publishing House: | London : : IntechOpen,, 2022. ©2022 |
| Year of Publication: | 2022 |
| Language: | English |
| Physical Description: | 1 online resource (ix, 266 pages) :; illustrations |
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Table of Contents:
- Preface
- Section 1 The State of Art
- Chapter 1 Introductory Chapter: Chagas Disease
- A Multidisciplinary Old Public Health Problem by Rubem Menna-Barreto
- Section 2 The Treatment
- Chapter 2 New Therapeutics for Chagas Disease: Charting a Course to Drug Approval by Anthony Man and Florencia Segal
- Chapter 3 The Saga of Selenium Treatment Investigation in Chagas Disease Cardiopathy: Translational Research in a Neglected Tropical Disease in Brazil by Tania C. de Araujo-Jorge, Anna Cristina C. Carvalho, Roberto R. Ferreira, Luciana R. Garzoni, Beatriz M.S. Gonzaga, Marcelo T. Holanda, Gilberto M. Sperandio da Silva, Maria da Gloria Bonecini-Almeida, Mauro F.F. Mediano, Roberto M. Saraiva and Alejandro M. Hasslocher-Moreno
- Chapter 4 Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning by Marcos André Vannier-Santos, Ana Márcia Suarez-Fontes, Juliana Almeida-Silva, Alessandra Lifsitch Viçosa, Sandra Aurora Chavez Perez, Alejandro Marcel Hasslocher-Moreno, Gabriel Parreiras Estolano da Silveira, Luciana Fernandes Portela and Roberto Magalhães Saraiva
- Section 3 The Pathogenesis
- Chapter 5 Digestive Disorders in Chagas Disease: Megaesophagus and Chagasic Megacolon by Víctor Hugo García Orozco, Juan Enrique Villalvazo Navarro, Carlos Solar Aguirre, Carlos Manuel Ibarra Ocampo, César Iván Díaz Sandoval, Carlos Alejandro Ortíz Gallegos, Diego Javier Oregel Camacho and Araceli Noriega Bucio
- Chapter 6 How Do Mouse Strains and Inoculation Routes Influence the Course of Experimental Trypanosoma cruzi Infection? by Flávia de Oliveira Cardoso, Carolina Salles Domingues, Tânia Zaverucha do Valle and Kátia da Silva Calabrese
- Chapter 7 Modulation of Host Cell Apoptosis by Trypanosoma cruzi: Repercussions in the Development of Chronic Chagasic Cardiomyopathy by Fiordaliso Carolina Román-Carraro, Diego Maurizio Coria-Paredes, Arturo A. Wilkins-Rodríguez and Laila Gutiérrez-Kobeh
- Chapter 8 Evaluation of Molecular Variability of Isolates of Trypanosoma cruzi in the State of Rio de Janeiro-Brazil by Helena Keiko Toma, Luciana Reboredo de Oliveira da Silva, Teresa Cristina Monte Gonçalves, Renato da Silva Junior and Jacenir R. Santos-Mallet.