Chagas Disease : : from cellular and molecular aspects of trypanosoma cruzi-host interactions to the clinical intervention / / edited by Rubem Menna-Barreto.

• TeilnehmendeR: Menna-Barreto, Rubem,
• Place / Publishing House: London : : IntechOpen,, 2022.; ©2022
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (ix, 266 pages) :; illustrations

Even 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial challenges that justify the intense research on this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species and vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features of the parasite's success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines. This book discusses Chagas disease and its etiological agent, including information on relevant clinical aspects such as diagnosis, treatment, biomarkers, and so on. It also presents information about cellular, molecular, and biochemical characteristics of the parasite-host interactions.

Table of Contents

Preface -- Section 1 The State of Art -- Chapter 1 Introductory Chapter: Chagas Disease -- A Multidisciplinary Old Public Health Problem by Rubem Menna-Barreto -- Section 2 The Treatment -- Chapter 2 New Therapeutics for Chagas Disease: Charting a Course to Drug Approval by Anthony Man and Florencia Segal -- Chapter 3 The Saga of Selenium Treatment Investigation in Chagas Disease Cardiopathy: Translational Research in a Neglected Tropical Disease in Brazil by Tania C. de Araujo-Jorge, Anna Cristina C. Carvalho, Roberto R. Ferreira, Luciana R. Garzoni, Beatriz M.S. Gonzaga, Marcelo T. Holanda, Gilberto M. Sperandio da Silva, Maria da Gloria Bonecini-Almeida, Mauro F.F. Mediano, Roberto M. Saraiva and Alejandro M. Hasslocher-Moreno -- Chapter 4 Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning by Marcos André Vannier-Santos, Ana Márcia Suarez-Fontes, Juliana Almeida-Silva, Alessandra Lifsitch Viçosa, Sandra Aurora Chavez Perez, Alejandro Marcel Hasslocher-Moreno, Gabriel Parreiras Estolano da Silveira, Luciana Fernandes Portela and Roberto Magalhães Saraiva -- Section 3 The Pathogenesis -- Chapter 5 Digestive Disorders in Chagas Disease: Megaesophagus and Chagasic Megacolon by Víctor Hugo García Orozco, Juan Enrique Villalvazo Navarro, Carlos Solar Aguirre, Carlos Manuel Ibarra Ocampo, César Iván Díaz Sandoval, Carlos Alejandro Ortíz Gallegos, Diego Javier Oregel Camacho and Araceli Noriega Bucio -- Chapter 6 How Do Mouse Strains and Inoculation Routes Influence the Course of Experimental Trypanosoma cruzi Infection? by Flávia de Oliveira Cardoso, Carolina Salles Domingues, Tânia Zaverucha do Valle and Kátia da Silva Calabrese -- Chapter 7 Modulation of Host Cell Apoptosis by Trypanosoma cruzi: Repercussions in the Development of Chronic Chagasic Cardiomyopathy by Fiordaliso Carolina Román-Carraro, Diego Maurizio Coria-Paredes, Arturo A. Wilkins-Rodríguez and Laila Gutiérrez-Kobeh -- Chapter 8 Evaluation of Molecular Variability of Isolates of Trypanosoma cruzi in the State of Rio de Janeiro-Brazil by Helena Keiko Toma, Luciana Reboredo de Oliveira da Silva, Teresa Cristina Monte Gonçalves, Renato da Silva Junior and Jacenir R. Santos-Mallet.