O-GlcNAcylation and cancer / / Ikram El Yazidi-Belkoura, Tony Lefebvre, (editors).

• TeilnehmendeR: Lefebvre, Tony ,; El Yazidi-Belkoura, Ikram,
• Place / Publishing House: Basel : : MDPI - Multidisciplinary Digital Publishing Institute,, [2022]; ©2022
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (112 pages)

his book gathers reviews and articles on the role of O-GlcNAcylation in cancer underlying the pharmacological targeting of the O-GlcNAcylation enzymes OGT and OGA as a promising anticancer strategy. Particular attention is paid to the involvement of O-GlcNAcylation in the regulation of transcription and as a link between nutrition and epigenetic dynamics or cellular energy metabolism. The role of O-GlcNAcylation in metastasis, immune responses, and resistance to chemotherapeutic agents is also discussed.

Table of Contents

1. Introduction -- 2. O-GlcNAcylation -- 2.2. Functions of O-GlcNAcylation -- 3. O-GlcNAcylation and Cancer -- 3.1. O-GlcNAcylation and Metastasis -- 3.2. O-GlcNAcylation and Receptor Tyrosine Kinase -- 3.3. O-GlcNAcylation and Resistance to Chemotherapy -- 3.4. O-GlcNAcylation as Prognostic Marker -- 4. O-GlcNAcylation and Immune Responses in Cancer -- 4.1. Overview of Immune System and O-GlcNAcylation -- 4.2. T Cell Activation and Differentiation Regulated by O-GlcNAcylation -- 4.3. Macrophage Differentiation and Activation by O-GlcNAcylation -- 4.4. O-GlcNAcylation and Tumor Microenvironment -- 5. Cancer Therapeutics Targeting O-GlcNAcylation -- 6. Conclusions and Future Perspectives -- Author Contributions -- Funding -- Conflicts of Interest -- Footnotes -- References.