Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / / Luiza Rusu.
Giant cell arteritis (GCA) is a primary systemic vasculitis characterized by systemic inflammation and vascular insufficiency of large and medium blood vessels which may lead to end-organ damage in patients age 50 and older. Standard corticosteroid treatment of GCA significantly improves the intima-...
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Place / Publishing House: | London : : IntechOpen,, 2021. |
Year of Publication: | 2021 |
Language: | English |
Physical Description: | 1 online resource (126 pages) |
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Rusu, Luiza, author. Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / Luiza Rusu. Giant Cell Arteritis London : IntechOpen, 2021. 1 online resource (126 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Description based on: online resource; title from PDF information screen (IntechOpen, viewed March 25, 2023). Giant cell arteritis (GCA) is a primary systemic vasculitis characterized by systemic inflammation and vascular insufficiency of large and medium blood vessels which may lead to end-organ damage in patients age 50 and older. Standard corticosteroid treatment of GCA significantly improves the intima-media thickness while having less influence on vascular endothelial dysfunction. GCA morbidity may be related to both cardiovascular complications and corticosteroid toxicity. Therefore, we aim to discuss 1 characteristic aspects of vascular damage, 2 several mechanisms that cause vascular dysfunction, intima-media 'nodular' thickness, progressive narrowing of the arterial lumen and vascular blockage in the context of systemic inflammation, thrombosis and of the cardiovascular complications in GCA and 3 new therapeutic glucocorticosteroid-sparing (GS) agents which might be a more productive way of avoiding the invalidating or life-threatening cardiovascular complications of GCA. Author information -- 1.Introduction -- 2.Characteristics of vascular damage in GCA arteries -- 3.Vascular remodeling of healthy arteries to GCA arteries -- 4.Vascular remodeling is the 'unmet need' in GCA treatment-standard therapy and future perspectives -- 5.Discussion and conclusions -- References. Arteritis. 1-83969-208-1 |
language |
English |
format |
eBook |
author |
Rusu, Luiza, |
spellingShingle |
Rusu, Luiza, Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / Author information -- 1.Introduction -- 2.Characteristics of vascular damage in GCA arteries -- 3.Vascular remodeling of healthy arteries to GCA arteries -- 4.Vascular remodeling is the 'unmet need' in GCA treatment-standard therapy and future perspectives -- 5.Discussion and conclusions -- References. |
author_facet |
Rusu, Luiza, |
author_variant |
l r lr |
author_role |
VerfasserIn |
author_sort |
Rusu, Luiza, |
title |
Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / |
title_full |
Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / Luiza Rusu. |
title_fullStr |
Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / Luiza Rusu. |
title_full_unstemmed |
Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / Luiza Rusu. |
title_auth |
Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / |
title_alt |
Giant Cell Arteritis |
title_new |
Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / |
title_sort |
cellular and molecular characteristics of vascular damage in giant cell arteritis, the unmet needs for targeted treatment / |
publisher |
IntechOpen, |
publishDate |
2021 |
physical |
1 online resource (126 pages) |
contents |
Author information -- 1.Introduction -- 2.Characteristics of vascular damage in GCA arteries -- 3.Vascular remodeling of healthy arteries to GCA arteries -- 4.Vascular remodeling is the 'unmet need' in GCA treatment-standard therapy and future perspectives -- 5.Discussion and conclusions -- References. |
isbn |
1-83969-209-X 1-83969-208-1 |
callnumber-first |
R - Medicine |
callnumber-subject |
RC - Internal Medicine |
callnumber-label |
RC694 |
callnumber-sort |
RC 3694.5 I53 R878 42021 |
illustrated |
Not Illustrated |
dewey-hundreds |
600 - Technology |
dewey-tens |
610 - Medicine & health |
dewey-ones |
616 - Diseases |
dewey-full |
616.13 |
dewey-sort |
3616.13 |
dewey-raw |
616.13 |
dewey-search |
616.13 |
work_keys_str_mv |
AT rusuluiza cellularandmolecularcharacteristicsofvasculardamageingiantcellarteritistheunmetneedsfortargetedtreatment AT rusuluiza giantcellarteritis |
status_str |
n |
ids_txt_mv |
(CKB)4920000002063839 (NjHacI)994920000002063839 (EXLCZ)994920000002063839 |
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is_hierarchy_title |
Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / |
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1764995749199740928 |
fullrecord |
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