Cellular and Molecular Characteristics of Vascular Damage in Giant Cell Arteritis, the Unmet Needs for Targeted Treatment / / Luiza Rusu.
Giant cell arteritis (GCA) is a primary systemic vasculitis characterized by systemic inflammation and vascular insufficiency of large and medium blood vessels which may lead to end-organ damage in patients age 50 and older. Standard corticosteroid treatment of GCA significantly improves the intima-...
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| Place / Publishing House: | London : : IntechOpen,, 2021. |
| Year of Publication: | 2021 |
| Language: | English |
| Physical Description: | 1 online resource (126 pages) |
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| Other title: | Giant Cell Arteritis |
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| Summary: | Giant cell arteritis (GCA) is a primary systemic vasculitis characterized by systemic inflammation and vascular insufficiency of large and medium blood vessels which may lead to end-organ damage in patients age 50 and older. Standard corticosteroid treatment of GCA significantly improves the intima-media thickness while having less influence on vascular endothelial dysfunction. GCA morbidity may be related to both cardiovascular complications and corticosteroid toxicity. Therefore, we aim to discuss 1 characteristic aspects of vascular damage, 2 several mechanisms that cause vascular dysfunction, intima-media 'nodular' thickness, progressive narrowing of the arterial lumen and vascular blockage in the context of systemic inflammation, thrombosis and of the cardiovascular complications in GCA and 3 new therapeutic glucocorticosteroid-sparing (GS) agents which might be a more productive way of avoiding the invalidating or life-threatening cardiovascular complications of GCA. |
| ISBN: | 183969209X |
| Hierarchical level: | Monograph |
| Statement of Responsibility: | Luiza Rusu. |