Dietary curcumin and health effects / / Francesca Cirulli, Roberta Masella (editors).

• TeilnehmendeR: Cirulli, Francesca,; Masella, Roberta,
• Place / Publishing House: [Basel] : : MDPI - Multidisciplinary Digital Publishing Institute,, 2023.
• Year of Publication: 2023
• Language: English
• Physical Description: 1 online resource (208 pages)

The Special Issue provides twelve contributions, of which three original articles, seven narrative reviews, one systematic review, and one meta-analysis that, altogether, offer a multifaceted and multidisciplinary overview that allows to draw a picture as intriguing and fascinating as possible on the benefits of curcumin and also to suggest potential fields of activities still to be explored. Among the biological activities exerted by curcumin, the anti-oxidative and anti-inflammatory properties reported in many studies make it a potential effective tool in preventing and counteracting chronic-degenerative diseases, very often associated with obesity and aging, such as cardiovascular diseases, T2D, metabolic dysfunctions, neurodegenerative diseases, and cancer, all of them characterized by the presence of oxidative and inflammatory processes. The main concerns that arise from the evaluation of the preventive/therapeutic effects of curcumin are, first of all, the still small number of randomized placebo-control studies available; in addition, small sample sizes have generally been considered, and different protocols and different formulations as well as different routes of administration of curcumin have been used. Thus, it is quite difficult to compare the results and to provide a standard protocol for the use of this promising natural compound. For these reasons, and taking in account the growing use of curcumin by the general population, further investigations to confirm and expand current findings are mandatory and research on curcumin and its effects on human health have to be fostered and promoted.

Table of Contents

About the Editors vii -- Preface to "Dietary Curcumin and Health Effects" ix -- Curcumin: A Promising Tool to Develop Preventive and Therapeutic Strategies against Non-Communicable Diseases, Still Requiring Verification by Sound Clinical Trials 1 -- Cytotoxic, Genotoxic and Senolytic Potential of Native and Micellar Curcumin 7 -- An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults 25 -- Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease 37 -- Curcumin and Its Potential Impact on Microbiota 49 -- Curcuma Longa, the "Golden Spice" to Counteract Neuroinflammaging and Cognitive -- Decline-What Have We Learned and What Needs to Be Done 61 -- Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role? 79 -- Anticancer Mechanism of Curcumin on Human Glioblastoma 93 -- Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes-A Meta-Analysis of Randomized Controlled Trial 113 -- Curcumin from Turmeric Rhizome: A Potential Modulator of DNA Methylation Machinery in Breast Cancer Inhibition 125 -- Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications? 147 -- Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin 165 -- The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials 183.