Molecular imaging in Parkinson's Disease / / Cristina Polito.
The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Florence underwent clinical assessment, neuropsychological...
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| Superior document: | Premio Firenze University Press tesi di dottorato (Series), ; 18 |
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| Place / Publishing House: | Firenze : : Firenze University Press,, 2011 |
| Year of Publication: | 2011 |
| Language: | Italian |
| Series: | Premio Firenze University Press tesi di dottorato (Series) ;
18. |
| Physical Description: | 1 online resource (68 pages) :; illustrations; digital, PDF file(s). |
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| Summary: | The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Florence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus. |
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| Bibliography: | Includes bibliographical references. |
| Access: | Open Access |
| Hierarchical level: | Monograph |
| Statement of Responsibility: | Cristina Polito. |