The Impact of Food Bioactives on Health : : in vitro and ex vivo models / / edited by Kitty Verhoeckx, Paul Cotter, Iván López-Expósito, Charlotte Kleiveland, Tor Lea, Alan Mackie, Teresa Requena, Dominika Swiatecka, Harry Wichers.

• HerausgeberIn: Verhoeckx, Kitty.; Cotter, Paul.; López-Expósito, Iván.; Kleiveland, Charlotte.; Lea, Tor.; Mackie, Alan.; Requena, Teresa.; Swiatecka, Dominika.; Wichers, Harry.
• Place / Publishing House: Cham : : Springer International Publishing :, Imprint: Springer,, 2015.
• Year of Publication: 2015
• Edition: 1st ed. 2015.
• Language: English
• Physical Description: 1 online resource (xvii, 338 pages) :; colour illustrations; digital, PDF file(s).
• Notes: Bibliographic Level Mode of Issuance: Monograph

This book describes in vitro and ex vivo models that can be employed to investigate effects of digested food products on the GIT, or specific components thereof. Many such models exist and include, for example, those used to study digestion and fermentation in the small and large intestine, to inves...

Table of Contents

• Introduction
• Gastrointestinal digestion models, general introduction
• Static digestion models general introduction
• InfoGest consensus method
• Approaches to static digestion models
• Dynamic digestion models general introduction
• The TNO gastro-Intestinal Model (TIM)
• Dynamic Gastric Model (DGM)
• Human Gastric Simulator (Riddet model)
• The DIDGI® System
• General introduction to cells, cell lines and cell culture
• Epithelial cell models; General introduction
• Caco-2 cell line
• HT29 cell line
• The IPEC-J2 cell line
• Co-cultivation of Caco-2 and HT-29MT
• Innate and adaptive immune cells; General introduction
• THP-1 and U937 cells
• Peripheral blood mononuclear cells
• PBMC-derived T cells
• Dendritic Cells
• Co-culture Caco-2/ immune cells
• Enteroendocrine Cell Models: General introduction
• STC-1 cells
• NCI-H716 cells
• Murine GLUTag cells
• In vitro intestinal tissue models: General introduction
• Intestinal crypt organoids as experimental models
• Porcine ex vivo intestinal segment model
• Ussing chamber
• In vitro fermentation models: General Introduction
• One compartment fermentation model
• The TNO in vitro model of the colon - TIM-2
• The Simulator of the Human Intestinal Microbial Ecosystem – SHIME®
• The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI.