Breaking the cycle : : attacking the malaria parasite in the liver / / edited by Ute Frevert, Urszula Krzych, Thomas L. Richie.
Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transm...
Saved in:
Superior document: | Frontiers in Human Neuroscience, |
---|---|
: | |
TeilnehmendeR: | |
Place / Publishing House: | [Place of publication not identified] : : Frontiers Media SA,, 2015. |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers in Human Neuroscience,
|
Physical Description: | 1 online resource (173 pages) :; illustrations, charts; digital, PDF file(s). |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993547671104498 |
---|---|
ctrlnum |
(CKB)3710000000631104 (oapen)https://directory.doabooks.org/handle/20.500.12854/42444 (EXLCZ)993710000000631104 |
collection |
bib_alma |
record_format |
marc |
spelling |
Richie, Thomas auth http://viaf.org/viaf/2373164842504613040006 Breaking the cycle : attacking the malaria parasite in the liver / edited by Ute Frevert, Urszula Krzych, Thomas L. Richie. Frontiers Media SA 2015 [Place of publication not identified] : Frontiers Media SA, 2015. 1 online resource (173 pages) : illustrations, charts; digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Frontiers research topics Frontiers in Human Neuroscience, 1664-8714 Includes bibliographical references. Open access Unrestricted online access star Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans – the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center’s DNA prime / Ad boost vaccine, Sanaria, Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Nijmegen Medical Centre’s chemoprophylaxis with sporozoites vaccine. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host’s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world’s population constantly at risk of malaria. Description based on e-publication, viewed on January 16, 2019. English Plasmodium falciparum. Malaria Immunological aspects. Malaria Prevention. Malaria Research. Liver Immunology. Liver Parasites. Hepatology. Plasmodis lemac CD8 T cell Plasmodium B cell antigen-presenting cell immune response Malaria vaccine hepatic microenvironment CD4 T cell animal model adjuvants Frevert, Ute editor Krzych, Urszula, editor, contributor. https://orcid.org/0000-0002-6428-3949 2-88919-695-X Frontiers in Human Neuroscience, 1664-8714. |
language |
English |
format |
eBook |
author |
Richie, Thomas |
spellingShingle |
Richie, Thomas Breaking the cycle : attacking the malaria parasite in the liver / Frontiers research topics Frontiers in Human Neuroscience, |
author_facet |
Richie, Thomas Frevert, Ute Krzych, Urszula, Richie, Thomas |
author_variant |
t r tr |
author2 |
Frevert, Ute Krzych, Urszula, Richie, Thomas |
author2_variant |
u f uf u k uk t r tr |
author2_role |
TeilnehmendeR TeilnehmendeR |
author_sort |
Richie, Thomas |
title |
Breaking the cycle : attacking the malaria parasite in the liver / |
title_sub |
attacking the malaria parasite in the liver / |
title_full |
Breaking the cycle : attacking the malaria parasite in the liver / edited by Ute Frevert, Urszula Krzych, Thomas L. Richie. |
title_fullStr |
Breaking the cycle : attacking the malaria parasite in the liver / edited by Ute Frevert, Urszula Krzych, Thomas L. Richie. |
title_full_unstemmed |
Breaking the cycle : attacking the malaria parasite in the liver / edited by Ute Frevert, Urszula Krzych, Thomas L. Richie. |
title_auth |
Breaking the cycle : attacking the malaria parasite in the liver / |
title_new |
Breaking the cycle : |
title_sort |
breaking the cycle : attacking the malaria parasite in the liver / |
series |
Frontiers research topics Frontiers in Human Neuroscience, |
series2 |
Frontiers research topics Frontiers in Human Neuroscience, |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (173 pages) : illustrations, charts; digital, PDF file(s). |
isbn |
2-88919-695-X |
issn |
1664-8714 |
illustrated |
Illustrated |
work_keys_str_mv |
AT richiethomas breakingthecycleattackingthemalariaparasiteintheliver AT frevertute breakingthecycleattackingthemalariaparasiteintheliver AT krzychurszula breakingthecycleattackingthemalariaparasiteintheliver |
status_str |
n |
ids_txt_mv |
(CKB)3710000000631104 (oapen)https://directory.doabooks.org/handle/20.500.12854/42444 (EXLCZ)993710000000631104 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers in Human Neuroscience, |
is_hierarchy_title |
Breaking the cycle : attacking the malaria parasite in the liver / |
container_title |
Frontiers in Human Neuroscience, |
author2_original_writing_str_mv |
noLinkedField noLinkedField noLinkedField |
_version_ |
1806055570907594752 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>04705nam a2200625 i 4500</leader><controlfield tag="001">993547671104498</controlfield><controlfield tag="005">20240730214743.0</controlfield><controlfield tag="006">m fo d 00| 0 </controlfield><controlfield tag="007">cr#c|#---|||||</controlfield><controlfield tag="008">160411s2015uuuuxx ad||fob 00|-0|eng|d</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/978-2-88919-695-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000631104</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/42444</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000631104</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">UkMaJRU</subfield><subfield code="e">rda</subfield><subfield code="d">NZ-WeVUL</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Richie, Thomas</subfield><subfield code="4">auth</subfield><subfield code="1">http://viaf.org/viaf/2373164842504613040006</subfield></datafield><datafield tag="245" ind1="0" ind2="0"><subfield code="a">Breaking the cycle :</subfield><subfield code="b">attacking the malaria parasite in the liver /</subfield><subfield code="c">edited by Ute Frevert, Urszula Krzych, Thomas L. Richie.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2015</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">[Place of publication not identified] :</subfield><subfield code="b">Frontiers Media SA,</subfield><subfield code="c">2015.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (173 pages) :</subfield><subfield code="b">illustrations, charts; digital, PDF file(s).</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">text file</subfield><subfield code="b">PDF</subfield><subfield code="2">rda</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Frontiers research topics</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers in Human Neuroscience,</subfield><subfield code="x">1664-8714</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="506" ind1=" " ind2=" "><subfield code="a">Open access</subfield><subfield code="f">Unrestricted online access</subfield><subfield code="2">star</subfield></datafield><datafield tag="520" ind1="3" ind2=" "><subfield code="a">Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans – the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center’s DNA prime / Ad boost vaccine, Sanaria, Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Nijmegen Medical Centre’s chemoprophylaxis with sporozoites vaccine. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host’s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world’s population constantly at risk of malaria.</subfield></datafield><datafield tag="588" ind1=" " ind2=" "><subfield code="a">Description based on e-publication, viewed on January 16, 2019.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Plasmodium falciparum.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Malaria</subfield><subfield code="x">Immunological aspects.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Malaria</subfield><subfield code="x">Prevention.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Malaria</subfield><subfield code="x">Research.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Liver</subfield><subfield code="x">Immunology.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Liver</subfield><subfield code="x">Parasites.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Hepatology.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Plasmodis</subfield><subfield code="2">lemac</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CD8 T cell</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Plasmodium</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">B cell</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">antigen-presenting cell</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">immune response</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Malaria vaccine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">hepatic microenvironment</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CD4 T cell</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">animal model</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">adjuvants</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Frevert, Ute</subfield><subfield code="e">editor</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Krzych, Urszula,</subfield><subfield code="e">editor, contributor.</subfield><subfield code="1">https://orcid.org/0000-0002-6428-3949</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Richie, Thomas</subfield><subfield code="4">auth</subfield><subfield code="1">http://viaf.org/viaf/2373164842504613040006</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88919-695-X</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Frontiers in Human Neuroscience,</subfield><subfield code="x">1664-8714.</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2024-07-31 01:04:12 Europe/Vienna</subfield><subfield code="d">00</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2016-04-12 04:07:06 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338613890004498&Force_direct=true</subfield><subfield code="Z">5338613890004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338613890004498</subfield></datafield></record></collection> |