Animal model studies on viral infections / Topic editors: Akio Adachi and Tomoyuki Miura.

• Superior document: Frontiers in microbiology
• Author: Tomoyuki Miura
• TeilnehmendeR: Adachi, Akio,; Miura, Tomoyuki,
• Place / Publishing House: [Place of publication not identified] : : Frontiers Media SA,, 2015.; ©2007-2015
• Year of Publication: 2015
• Language: English
• Series: Frontiers in microbiology.
• Physical Description: 1 online resource (173 pages) :; illustrations; digital, PDF file(s).

Understanding viral replication and pathogenicity properties in infected individuals is a major mission of animal virology. Animal models are essential to analyze the in vivo viral characteristics and to develop countermeasures against viruses. To fight against a wide variety of viruses, basic studies with specific and/ or common approaches are required. This Research Topic collects articles that describe studies on numerous virus species at various stages toward animal experiments: (i) description/evaluation/ new challenges of animal model studies; (ii) experimental material/methods for animal model studies; (iii) observations for upcoming animal model studies. Numbers of DNA and RNA viruses such as HHV-6, HPV, Ebola virus, HCV, dengue virus, HTLV-1, HIV-1, SIV, and measles virus are covered by this special issue consisting of original research, methods, review, mini-review, and opinion articles. All readers would understand, we believe and hope, that animal model studies are critical for current virology as always.

Table of Contents

Animal model studies on viral infections --Animal models for human Herpesvirus 6 infection --Animal models for Ebola and Marburg virus infections --Hepatitis C virus infection and related liver disease: the quest for the best animal model --Can non-human primates serve as models for investigating Dengue disease pathogenesis? --A transgenic mouse model of human T cell Leukemia virus type-1 associated diseases --Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus --Macaques as model hosts for studies of HIV-1 infection --Macaque-tropic Human Immunodeficiency Virus type 1: breaking out of the host restriction factors --Genetic similarity of circulating and small intestinal virus at the end stage of acute pathogenic Simian-Human Immunodeficiency Virus infection --A novel but simple method for generation of human dendritic cells from unfractionated peripheral blood mononuclear cells within 2 days: its application for induction of HIV-1-reactive CD4⁺ T cells in the hu-PBL SCID mice --Growth potentials of CCR5-Tropic/CXCR4-Tropic HIV-1mt clones in macaque cells --Sensitive detection of measles virus infection in the blood and tissues of humanized mouse by one-step quantitative RT-PCR --Quantification of viral infection dynamics in animal experiments --Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells --Increased infectivity in human cells and resistant to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail --Natural infection of murine novovirus in conventional and specific pathogen free laboratory mice --HPV18 E1̂ˆ̂E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.