Ubiquitination in Health and Diseases
Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena,...
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| Year of Publication: | 2021 |
| Language: | English |
| Physical Description: | 1 electronic resource (292 p.) |
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Ishigami, Tomoaki edt Ubiquitination in Health and Diseases Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (292 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field. English Humanities bicssc Social interaction bicssc deubiquitinase degradation therapeutic target cancer hematopoiesis hematopoietic stem cells immune response regulation of gene expression ubiquitin system genetic diseases ubiquitin ligase deubiquitinases monoubiquitin signaling vesicular trafficking protein complex formation inflammation inhibitor innate immune interferon LUBAC NF-κB ubiquitin Parkinson’s disease dopa-responsive dystonia tyrosine hydroxylase α-synuclein fatty acid-binding protein 3 ubiquitination proteasomal degradation ubiquitin-proteasome system mitochondria E3 ubiquitin ligase MITOL/MARCH5 salt-sensitive hypertension Nedd4L/Nedd4-2 epithelial sodium channel aldosterone sensitive distal nephron excitation-transcription coupling RNF183 RNF186 RNF182 RNF152 RING finger mTOR endoplasmic reticulum stress osmotic stress ubiquitin code virus infection virus-host interaction tau protein semisynthesis disulfide-coupling polyubiquitin fibrils aggregation neurodegeneration deubiquitination inhibitors protein quality control proteolysis protein stabilization regulatory T cells mesenchymal stem cell cortical bone derived stem cell myocardial infarction blood pressure renal salt reabsorption vascular function ubiquitin proteasome system ubiquitin–proteasome pathway cilia ciliogenesis differentiation proliferation ciliopathy E3s DUBs UPS neurodegenerative disease immune-related diseases 3-0365-0546-6 3-0365-0547-4 Ishigami, Tomoaki oth |
| language |
English |
| format |
eBook |
| author2 |
Ishigami, Tomoaki |
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Ishigami, Tomoaki |
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t i ti |
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Sonstige |
| title |
Ubiquitination in Health and Diseases |
| spellingShingle |
Ubiquitination in Health and Diseases |
| title_full |
Ubiquitination in Health and Diseases |
| title_fullStr |
Ubiquitination in Health and Diseases |
| title_full_unstemmed |
Ubiquitination in Health and Diseases |
| title_auth |
Ubiquitination in Health and Diseases |
| title_new |
Ubiquitination in Health and Diseases |
| title_sort |
ubiquitination in health and diseases |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2021 |
| physical |
1 electronic resource (292 p.) |
| isbn |
3-0365-0546-6 3-0365-0547-4 |
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Not Illustrated |
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AT ishigamitomoaki ubiquitinationinhealthanddiseases |
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