Prions : : Some Physiological and Pathophysiological Aspects / / edited by Ivo Nikolaev Sirakov.
The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic di...
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Place / Publishing House: | London, United Kingdom : : IntechOpen,, 2019. |
Year of Publication: | 2019 |
Language: | English |
Physical Description: | 1 online resource (82 pages) :; illustrations some color |
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(CKB)4970000000100424 (NjHacI)994970000000100424 (oapen)https://directory.doabooks.org/handle/20.500.12854/66955 (EXLCZ)994970000000100424 |
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Nikolaev Sirakov, Ivo edt Prions : Some Physiological and Pathophysiological Aspects / edited by Ivo Nikolaev Sirakov. Prions IntechOpen 2019 London, United Kingdom : IntechOpen, 2019. 1 online resource (82 pages) : illustrations some color text txt rdacontent computer c rdamedia online resource cr rdacarrier Description based on: online resource; title from PDF information screen (Intech, viewed October 17, 2022). Includes bibliographical references. The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE. English Prion diseases. Infectious & contagious diseases 1-78985-017-7 Sirakov, Ivo Nikolaev, editor. |
language |
English |
format |
eBook |
author2 |
Sirakov, Ivo Nikolaev, |
author_facet |
Sirakov, Ivo Nikolaev, |
author2_variant |
s i n si sin i n s in ins |
author2_role |
TeilnehmendeR |
title |
Prions : Some Physiological and Pathophysiological Aspects / |
spellingShingle |
Prions : Some Physiological and Pathophysiological Aspects / |
title_sub |
Some Physiological and Pathophysiological Aspects / |
title_full |
Prions : Some Physiological and Pathophysiological Aspects / edited by Ivo Nikolaev Sirakov. |
title_fullStr |
Prions : Some Physiological and Pathophysiological Aspects / edited by Ivo Nikolaev Sirakov. |
title_full_unstemmed |
Prions : Some Physiological and Pathophysiological Aspects / edited by Ivo Nikolaev Sirakov. |
title_auth |
Prions : Some Physiological and Pathophysiological Aspects / |
title_alt |
Prions |
title_new |
Prions : |
title_sort |
prions : some physiological and pathophysiological aspects / |
publisher |
IntechOpen IntechOpen, |
publishDate |
2019 |
physical |
1 online resource (82 pages) : illustrations some color |
isbn |
1-83881-768-9 1-78985-018-5 1-78985-017-7 |
callnumber-first |
Q - Science |
callnumber-subject |
QR - Microbiology |
callnumber-label |
QR201 |
callnumber-sort |
QR 3201 P737 S664 42019 |
illustrated |
Illustrated |
dewey-hundreds |
500 - Science |
dewey-tens |
570 - Life sciences; biology |
dewey-ones |
579 - Microorganisms, fungi & algae |
dewey-full |
579.29 |
dewey-sort |
3579.29 |
dewey-raw |
579.29 |
dewey-search |
579.29 |
work_keys_str_mv |
AT nikolaevsirakovivo prionssomephysiologicalandpathophysiologicalaspects AT sirakovivonikolaev prionssomephysiologicalandpathophysiologicalaspects AT nikolaevsirakovivo prions AT sirakovivonikolaev prions |
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(CKB)4970000000100424 (NjHacI)994970000000100424 (oapen)https://directory.doabooks.org/handle/20.500.12854/66955 (EXLCZ)994970000000100424 |
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Prions : Some Physiological and Pathophysiological Aspects / |
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