Prions : : Some Physiological and Pathophysiological Aspects / / edited by Ivo Nikolaev Sirakov.
The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic di...
Saved in:
TeilnehmendeR: | |
---|---|
Place / Publishing House: | London, United Kingdom : : IntechOpen,, 2019. |
Year of Publication: | 2019 |
Language: | English |
Physical Description: | 1 online resource (82 pages) :; illustrations some color |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
LEADER | 01078nam a2200301 i 4500 | ||
---|---|---|---|
001 | 993545821204498 | ||
005 | 20221017104654.0 | ||
006 | m o d | ||
007 | cr ||||||||||| | ||
008 | 221017s2019 enka ob 000 0 eng d | ||
020 | |a 1-83881-768-9 | ||
020 | |a 1-78985-018-5 | ||
035 | |a (CKB)4970000000100424 | ||
035 | |a (NjHacI)994970000000100424 | ||
035 | |a (oapen)https://directory.doabooks.org/handle/20.500.12854/66955 | ||
035 | |a (EXLCZ)994970000000100424 | ||
040 | |a NjHacI |b eng |e rda |c NjHacl | ||
041 | 0 | |a eng | |
050 | 4 | |a QR201.P737 |b .S664 2019 | |
082 | 0 | 4 | |a 579.29 |2 23 |
100 | 1 | |a Nikolaev Sirakov, Ivo |4 edt | |
245 | 0 | 0 | |a Prions : |b Some Physiological and Pathophysiological Aspects / |c edited by Ivo Nikolaev Sirakov. |
246 | |a Prions | ||
260 | |b IntechOpen |c 2019 | ||
264 | 1 | |a London, United Kingdom : |b IntechOpen, |c 2019. | |
300 | |a 1 online resource (82 pages) : |b illustrations some color | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
588 | |a Description based on: online resource; title from PDF information screen (Intech, viewed October 17, 2022). | ||
504 | |a Includes bibliographical references. | ||
520 | |a The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE. | ||
546 | |a English | ||
650 | 0 | |a Prion diseases. | |
653 | |a Infectious & contagious diseases | ||
776 | |z 1-78985-017-7 | ||
700 | 1 | |a Sirakov, Ivo Nikolaev, |e editor. | |
906 | |a BOOK | ||
ADM | |b 2023-02-22 19:53:58 Europe/Vienna |f system |c marc21 |a 2019-04-13 22:04:18 Europe/Vienna |g false | ||
AVE | |i DOAB Directory of Open Access Books |P DOAB Directory of Open Access Books |x https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338098880004498&Force_direct=true |Z 5338098880004498 |b Available |8 5338098880004498 |