A master regulator of oxidative stress : : the transcription factor Nrf2 / / edited by Jose Antonio Morales-Gonzalez, Ángel Morales-González, Eduardo Osiris Madrigal-Santillan.
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. The...
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| Place / Publishing House: | Rijeka, Croatia : : IntechOpen,, [2016] ©2016 |
| Year of Publication: | 2016 |
| Language: | English |
| Physical Description: | 1 online resource (210 pages) :; illustrations |
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| Other title: | Master regulator of oxidative stress A Master Regulator of Oxidative Stress â The Transcription Factor Nrf2 |
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| Summary: | Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways. |
| Bibliography: | Includes bibliographical references. |
| ISBN: | 9535154621 9535128388 |
| Access: | Open access |
| Hierarchical level: | Monograph |
| Statement of Responsibility: | edited by Jose Antonio Morales-Gonzalez, Ángel Morales-González, Eduardo Osiris Madrigal-Santillan. |