The Construction of Analogy-Based Research Programs : : The Lock-and-Key Analogy in 20th Century Biochemistry / / Rebecca Mertens.
When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical struc...
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Superior document: | Title is part of eBook package: De Gruyter DG Plus PP Package 2019 Part 2 |
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Place / Publishing House: | Bielefeld : : transcript Verlag, , [2019] ©2019 |
Year of Publication: | 2019 |
Language: | English |
Series: | Science Studies
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Online Access: | |
Physical Description: | 1 online resource (224 p.) |
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Other title: | Frontmatter -- Table of contents -- Preface -- 1 The lock-and-key analogy and its influence on 20th century biochemistry -- 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907 -- 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930 -- 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960 -- 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs -- 6 Concluding remarks on the construction of analogy-based research programs -- Literature |
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Summary: | When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity.Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. |
Format: | Mode of access: Internet via World Wide Web. |
ISBN: | 9783839444429 9783110766691 9783110719567 9783110610765 9783110664232 9783110610178 9783110606195 9783110662771 |
DOI: | 10.1515/9783839444429?locatt=mode:legacy |
Access: | restricted access |
Hierarchical level: | Monograph |
Statement of Responsibility: | Rebecca Mertens. |