Chemistry and Biology of Pteridines : : Pteridines and Folic Acid Derivatives. Proceedings of the International Symposium on Pteridines and Folic Acid Derivatives, Chemical, Biological and Clinical Aspects. / 7, : St. Andrews, Scotland, September 21–24, 1982 / / ed. by John A. Blair.
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Table of Contents:
- Frontmatter
- Preface
- ACKNOWLEDGEMENTS
- PARTICIPANTS
- Contents
- The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds
- Chemical Aspects (1)
- Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products
- Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins
- The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones]
- Some Simple s-Triazolopteridines
- Linear Tricyclic Analogs of Pteridines
- Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis
- Syntheses of some Blocked 7,8-Dihydropteridines
- Synthesis of Chiral Reduced Pteridine Coenzymes
- Report on Discussions
- Chemical Aspects (2)
- Reactivity of Pteridines
- Synthesis and Antitumor Activity of 10-Deazaminopterins
- Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin
- The Nor-Analogues of Folic Acid
- Report on Discussions
- Neurochemical and Clinical Aspects
- Metabolism of Pteridine Cofactors in Neurochemistry
- Pteridines in Cancer and Other Diseases
- Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing
- A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSE
- Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate
- Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis
- Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia
- Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers
- Report on Discussions
- Enzymology
- The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase
- Catalytic Site of Dihydrofolate Reductase
- Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase
- Methylene Tetrahydrofoíate Reductase: Studies in a Human Mutant and Mammalian Liver
- Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine
- Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis
- The Mechanism of Action of the Transformylase Enzymes
- Folypolyglutamate Synthesis in Neurospora Crassa
- Report on Discussions
- Clinical Aspects: Cancer
- Folates and Cancer Chemotherapy
- Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells
- A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells
- Further Characterization of the Pterdine Binding Variant of Alphas-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases
- Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates
- Attempts to Design Inhibitors of Dihydrofolate Reductase Using Interactive Computer Graphics with Real Time Energy Calculations
- Control of Methotrexate Polyglutamate Synthesis in Cultured Rat Hepatoma Cells
- Differential Effects of Methotrexate or Fluorodeoxyuridine upon Mitochondrial and Cellular Nucleotide Pools
- Report on Discussions
- Bioorganic Chemistry and Enzymology
- Chemical Mechanisms in the Action of Pteridine Coenzymes
- Irreversible Inactivation of Rat Liver Phenylalanine Hydroxylase by Reaction with (6S)-L-Erythro-Tetrahydrobiopterin
- p-Azidophenylalanine: A Potential Photoaffinity Probe for Rat-Liver Phenylalanine Hydroxylase
- Pyrimidine Models for the Cofactor of Phenylalanine Hydroxylase
- Activation of Molecular Oxygen by Tetrahydropterin Monooxygenases
- Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates
- Properties of Thymidylate Synthase from Streptococcus Faecium
- Cloning the Gene for Eukaryotic C1-THF Synthase
- Report on Discussions
- Biochemistry and Biology
- The Enzymatic Synthesis of the Drosopterins: Identification of a Pyrimidodiazepine as an Intermediate
- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis
- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis
- The Role of Pteridines in Regulation of Growth
- Evidence for a Folate Bound to Rat Hepatic Uroporphyrinogen III Cosynthase and its Role in the Biosynthesis of Heme
- Report on Discussions
- Presented Papers
- Aerobic Oxidation of 5,6,7,8-Tetrahydroneopterin
- The Conformations of 7,8 (6H)-Dihydropterin Substrates and the Activity of Dihydropteridine Reductase (E.C.1.6.99.10)
- Dihydrofolate Reductase: The Stereochemistry of Inhibitor Selectivity
- Synthesis of an 8-Deaza Analog of the Intermediate in the Thymidylate Synthetase Reaction (1)
- The Synthesis of Analogs of Pteroylglatamyl-y-Phosphate as Potential Inhibitors of Folylpolyglutamate Synthetase
- Synthesis and Activity of 8,10-Dideazaminopterin
- CNDO/2 Molecular Orbital Calculations on the Antifolate DAMP and Some of its Analogues: Conformational Characteristics
- Fluorescent Analogues of Methotrexate as Probes for Folate Antagonist Molecular Receptors
- Dihydrofolate Reductase Overproduction Identified by Flow Cytometry Using a Fluorescent Methotrexate Analogue
- New Syntheses and Transformations of Some Pteridines and Pteridine 3-Oxides
- Photooxidation of Mercaptopteridines
- Reactivity of 6,7-Dichloro-1, 3-Dimethyllumazine
- Synthesis, Reactivity and Properties of 8-Substituted 2-Thio- and 2,4-Dithiolumazines
- The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures
- Structural Studies of Antifolate Drugs
- Isolation and Characterization of a Novel Folate Antagonist
- Synthesis and Biological Properties of the S-8 Analog of 7,8-Dihydropteridinealcohol
- Synthesis of Dihydrobiopterin from Dihydroneopterin Triphosphate in Rat Tissues and Human Blood Corpuscles: Diagnosis of Atypical Phenylketonuria due to Biopterin Deficiency by Assay of an Enzyme Involved in the Synthesis
- Stereospecific Enzyme Mediated Syntheses of Tetrahydrofolate Derivatives
- Immobilization of Dihydrofolate Reductase from Amethopterin Resistant Lactobacillus Casei
- X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase
- A New Spectrophotometry Method for the Assessment of Tight Binding Benzyldiaminopyrimidine Inhibitors of Dihydrofolate Reductase
- Two Interconverting Conformers of a Drug-Receptor Complex: The Lactobacillus Casei Dihydrofolate Reductase-NADP+ - Trimethoprim Complex
- Multiple Conformations of the Dihydrofolate Reductase- Folate-NADP+ Complex
- The Three-Dimensional Structure of Mouse L1210 Dihydrofolate Reductase
- Isolation and Amino Acid Sequence Studies of Dihydrofolate Reductase from Neisseria Gonorrhoeae
- Purification of 7,8-Dihydropteroate-Synthetase from E. Coli by Affinity- and Hydrophobic Interaction Chromatography
- Isolation and Characterization of an E.
- Coli Mutant Affected in Dihydrofolate- and Folylpolyglutamate- Synthetase
- Purification and Properties of 5-Formyltetrahydrofolate Cyclodehydrase from Rabbit Liver
- Structural Studies on Formyl-Methenyl-Methylene Tetrahydrofolate Synthetase from Rabbit Liver
- Utilization of Folate Polyglutamate for Growth by Lactobacillus Casei
- Folate and Folate Enzymes as Structural Components of Bacteriophage Particles
- Studies on the Substrate Specificity of Mammalian Folylpolyglutamate Synthetase
- Properties of Corynebacterium Species Dihydrofolate Synthetase-Folylpolyglutamate Synthetase
- Purification and Characterization of Folylpolyglutamate Synthetase from Lactobacillus Casei and Hog Liver
- The Molybdenum Cofactor from Xanthine Oxidase: Quantitative Assay of the Molybdenum Cofactor by Activation of Nitrate Reductase Activity in Extracts of the Nit-1 Mutant of Neurospora crassa
- Structural Studies of Calf Thymus Thymidylate Synthase
- A Comparison of the T-Even Phage Induced and Escherichia Coli Thymidylate Synthases
- Thermophilicity of Dihydrofolate Reductase and Thymidylate Synthetase from a Thermophilic Microorganism
- Chemical Characterization of Two Folate-Binding Proteins from Mitochondria: Dimethylglycine Dehydrogenase and Sarcosine Dehydrogenase
- Allosteric Mung Bean (Vigna radiata) Serine Hydroxylmethyl-Transferase
- Comparative Study of the Eye Colour Mutants of Drosophila Melanogaster: Quantification of the Eye-Pigments and Related Metabolites
- Studies on Sepialumazine, the Characteristic Larval Integument Pigment of the Bombyx Mori Kiuki Mutant
- Macromolecular Regulation of Sepiapterin and Drosopterin Synthesis in the Purple Mutant of Drosophila
- The Hydroxylation of Phenylpropanoids by Euglena gracilis : Role of Pteridines
- Studies with Old Yellow Enzyme, Reconstitution with Lumazine Analogs as Coenzyme
- Biosynthesis of Riboflavin
- Biosynthesis of Riboflavin
- Metabolism and Function of Pterin Compounds in Seed Germination
- Thymidylate Synthetase During Proliferation and Differentiation of Physarum polycephalum
- Influence of Vitamin B12 on Folate Metabolism in Lactobacillus Leichmannii
- High-Affinity Binding of Folate to a Small and Large Molecular Size Protein from Human Milk
- High-Affinity Folate Binding in Leukocytes from Normal Subjects Displays Positive Cooperativity, and the Affinity Depends on the Protein Concentration
- Characteristics of 5-Methyltetrahydrofolate Binding to the Folate-Binding Protein from Cow's Whey
- Interactions of Folate-Dependent Enzymes of DNA Precursor Metabolism in T4 Phage-Infected Bacteria
- The Regulation of Biopterin Biosynthesis in the Rat
- Biosynthesis of Tetrahydrobiopterin in Mammalian Tissues by De Novo and Salvage Pathways
- Perspectives on Tetrahydrobiopterin Biosynthesis in Mammals
- Human Dihydropteridine Reductase (DHPR) Deficiency
- Coordinate Regulation of Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Adrenal Medullary Chromaffin Cells
- Regulation of Adrenocortical Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Normal and Spontaneously Hypertensive Rats
- Inhibition of Brain Sepiapterin Reductase by a Catecholamine and an Indoleamine
- Mouse Mastocytoma Tryptophan Hydroxylase: Role of Iron and Catalase in the Expression of Enzyme Activity after Activation by Anaerobic Preincubation with Dithiothreitol
- Folic Acid Induced Kindling in Rats: Changes in Brain Amino Acids
- Impaired Pteroylpolyglutamate Synthesis in the Cobalamin-Inactivated Rat
- A Radioimmunoassay for Determination of D-Erythro- Neopterin
- Radioimmunoassay for Neopterin in Body Fluid and Tissues
- A Specific Antiserum Against Tetrahydrobiopterin: Its Preparation and Application to Immunohistochemistry
- Speculation on the Mechanism of Therapeutic Action of Tetrahydrobiopterin in Human Disease
- Correlation of Tetrahydrobiopterin Content and Guanosine Triphosphate Cyclohydrolase Activity in Cells and Tissues
- Unconjugated Pteridines in Human Physiological Fluids. Normal and Pathological Profiles
- Biopterin and Phenylalanine Metabolism During Early Liver Regeneration
- GTP-Cyclohydrolase Activities in Rat Liver
- Phenylalanine Hydroxylase Assay Using Biopterin and Synthetic Pteridine
- Dihydropteridine Reductase Levels in Human Normal and Neoplastic Tissues
- Investigations of Tissue Folates in Normal and Malignant Tissues
- Blood Cell Biopterin as an Indicator of Transplanation- Induced Hemopoiesis and Leukemic Cell Proliferation
- Assessment of Urinary Neopterin in the Early Diagnosis of Human Allograft Rejection
- Behaviour of Neopterin Levels in Patients with Haematological and Gynaecological Neoplasms
- Pteridines in Dictyostelium discoideum and Physarum polycephalum
- Biochemical and Chemotherapy Studies on BW 301U, a Novel Lipophilic 2,4-Diaminopyridopyrimidine Antifolate
- Toxicity of a Series of Antifolate Compounds in a Methotrexate-Resistant Celi Line
- Interaction of Methotrexate Poly(L-Lysine) with Transformed Hepatic Cells in Culture
- A Novel Technique for Producing Folate-Deficient Hepatica Cells
- Methotrexate Metabolism in Acute Lymphoblastic Leukemia
- Altered Methotrexate Sensitivity in Human Leukemic K562 Amino Acid Transport Mutant Cells
- Methotrexate and Methotrexate Polyglutamates in Erythrocytes After High-Dose Methotrexate
- Methotrexate Polyglutamates in Human Fibroblasts: Reversal of Antifolate Cytotoxicity
- Human Cells Resistant to Methotrexate: Cross Resistance and Collateral Sensitivity to the Nonclassical Antifolates Trimetrexate, Metoprine, Homofolic Acid and CB3717
- Homology of Two Forms of Dihydrofolate Reductase in Human Leukaemic and L1210 Cells During Expression of Resistance to Methotrexate
- Adaptation of Folylpolyglutamates to Folate Deprivation in Mouse Hepatoma Cells
- Utilization and Loss of Reduced Folates by Human Fibroblasts in Vitro
- Factors Affecting Folate Polyglutamate Biosynthesis in Rat Liver
- Differential Binding of Folates but not Methotrexate (MTX) by Brush Border (BB) and Basal Lateral (BL) Membranes of Rat Renal Cortex
- Biosynthesis of Folate Derivatives in Ehrlich Ascites Carcinoma Cells Grown in Mice and in some Organs of the Host
- Variability of Thymidylate Synthetase in Ehrlich Carcinoma Cells and its Role in Resistance to 5-Fluorodeoxyuridine
- One-Carbon Metabolism in Human Lymphocytes
- Possible Mechanisms of Folate Catabolism
- The Intracellular Folate Pool: Studies of Kinetics and Functional Significance
- Intestinal Folate Transport. A pH-Dependent, Carrier- Mediated Process
- Effects of Folate Depletion on Growth and Survival of Human Cell Line K-562 in Culture
- Alterations in Folate Metabolism of the Rat Induced by Acute Ethanol Administration
- Participation of Pterins in the Control of Lymphocyte Transformation and Lymphoblast Proliferation
- The Pterin Component of the Molybdenum Cofactor (Molybdopterin): Relationship to Urothione
- Report on Presented Papers
- Author Index
- Subject Index
- Backmatter
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