Chemistry and Biology of Pteridines : : Pteridines and Folic Acid Derivatives. Proceedings of the International Symposium on Pteridines and Folic Acid Derivatives, Chemical, Biological and Clinical Aspects. / 7, : St. Andrews, Scotland, September 21–24, 1982 / / ed. by John A. Blair.

• Superior document: Title is part of eBook package: De Gruyter DGBA Reference Works <1990
• MitwirkendeR: Abou-Donia, M. M.,; Abou-Donia, Martha M.,; Abou-Hadeed, Khaled,; Abramson, R. G.,; Ahmed, Faizy,; Akino, Miki,; Al-Beir, A.,; Allan, R. N.,; Allen, J. R.,; Anstead, G. M.,; Appaji Rao, N.,; Armarego, W. L. F.,; Armarego, Wilfred L. F.,; Armarego, Wilfred L.F.,; Atarés, M.,; Ayling, June E.,; Baccanari, D. P.,; Bacher, Adelbert,; Bailey, Steven W.,; Baker, D. J.,; Baker, Dorothea J.,; Balinska, Malgorzata,; Ballou, David P.,; Barford, P. A.,; Barford, P.A.,; Bartels, Rainer,; Bartke, Michael,; Bates, J.,; Baugh, C. M.,; Baur, Ralph,; Beardsley, G. Peter,; Beddell, C. R.,; Beddell, Christopher R.,; Bees, Lilias,; Beifort, Marlene,; Bellahsene, Z.,; Bellahsene, Zina,; Benkovic, Patricia A.,; Benkovic, S. J.,; Benkovic, Stephen J.,; Berends, W.,; Berndt, Jürgen,; Berry, Helen K.,; Bertino, J. R.,; Bertino, J.R.,; Bestwick, Richard K.,; Bevan, A. W.,; Birdsall, B.,; Black, A. M.,; Blair, J. A.,; Blair, J.A.,; Blakley, Raymond L.,; Blankenship, D. T.,; Bobinson, David H.,; Bock, Lothar,; Bodenberger, Ulrich,; Bognar, Andrew L.,; Bolin, J. T.,; Bonneterre, J.,; Bonneterre, Jacques,; Booth, Joseph W.,; Boyle, P. H.,; Boyle, Peter,; Bray, Robert C.,; Broom, Arthur D.,; Brown, Desmond J.,; Brown, Gene M.,; Brown, V. H.,; Burge, A. S. V.,; Burgen, A. S. V.,; Bühler, Matthias,; Cameron, Bobert C.,; Campbell, Caryl L.,; Cardesa-Garcia, J.,; Champness, J. N.,; Champness, J. Ν.,; Champness, John N.,; Chan, Joseph H.,; Chan, M.M-S.,; Chan, P. Y.,; Chanarin, I.,; Choolun, R.,; Choteau, P.,; Cichowiez, David J.,; Clement, R. P.,; Clore, G. M.,; Cocco, Lennie,; Cody, Vivian,; Collins, Timothy D.,; Cook, Robert J.,; Cooper, Bernard A.,; Corrocher, Roberto,; Cossins, E.A.,; Cotton, R. G. H.,; Cotton, Richard G.H.,; Coward, J. Κ.,; Coward, James K.,; Craig, G.,; Curtius, H.-Ch.,; Daluge, Susan,; Daniels, A. J.,; Daniels, Alejandro J.,; Danks, David M.,; Dann, J. G.,; Daubner, S. Colette,; Dautrevaux, Michel,; DeBrosse, Charles W.,; DeGraw, J. I.,; DeJarnette, Elaine,; Deacon, Rosemary,; Delcamp, T. J.,; Demaille, Alain,; Deschenes, R.,; Dhondt, J.-L.,; Dhondt, Jean-Louis,; Diddens, Heyke,; Doig, M. T.,; Dolores Real, Maria,; Dorsett, D.,; Dow, Jocelyn,; Doyle, Paul M.,; Duch, David S.,; Dunlap, R. Bruce,; Dwivedi, Chandra M.,; Eggar, C.,; Elstner,,; Elwell, Lynn P.,; Erbe, Richard W.,; Farriaux, J. P.,; Farriaux, Jean-Pierre,; Feeney, J.,; Ferone, R.,; Ferone, Robert,; Ferré, Juan,; Filman, D. J.,; Fink, Michael,; Fink, Rita,; Firgaira, Frank A.,; Floss, Heinz G.,; Fonda, Susan,; Freisheim, J. H.,; Freisheim, J.H.,; Frisius, Hildegard,; Fuchs, D.,; Fuchs, Dietmar,; Galivan, John,; Gaumont, Y.,; Geddes, A. J.,; Gerisch, Günther,; Ghisla, Sandro,; Goldman, Daniel A.,; Goodford, P. J.,; Goodford, Peter J.,; Grimshaw, C.E.,; Gronenborn, A.,; Grossowicz, Nathan,; Grzelakowska-Sztabert, Barbara,; Gröbner, Peter,; Guest, A. E.,; Hainline, Bryan E.,; Ham, Ulrike,; Hamrell, Michael R.,; Hanlon, M. H.,; Hansen, Steen Ingemann,; Harding, Nigel,; Harrington, Peter J.,; Hasegawa, Hiroyuki,; Hausen, A.,; Hausen, Arno,; Hausen, Α.,; Hawkes, Timothy R.,; Hearl, W. G.,; Heckel, Armin,; Heintel, D.,; Henderson, G.B.,; Herlin, Christophe,; Hillman, Robert S.,; Hilton, Jack H.,; Holm, Jan,; Hopkins, Sam,; Hsieh, Monica,; Hsieh, P.,; Huber, Ch.,; Huennekens, F.M.,; Hyde, E. I.,; Hyde, Richard M.,; Häusermann, M.,; Hübsch, Walter,; Hüfner, Michael,; Ichiyama, Arata,; Inoue, Fumio,; Inoue, Kayo,; Iqbal, M. Perwaiz,; Iwai, Kazuo,; Jackson, Robert C.,; Jacobsen, D.W.,; Jacobson, K. Bruce,; Jastreboff, Malgorzata,; Johnson, Jean L.,; Jongejan, J. A.,; Kapatos, Gregory,; Karasik, M.,; Kassan, Sharon,; Katoh, S.,; Kaufman, S.,; Kaufman, Seymour,; Keating, S.,; Keller, Paul J.,; Kelly, L. F.,; Kempton, R. J.,; Kfdzierska, Barbara,; King, F. V.,; Kisliuk, R. L.,; Kisliuk, R.L.,; Kisliuk, Roy L.,; Kisthard, Holly,; Klein Amy, Nancy,; Kohashi, M.,; Kohashi, Masahiro,; Kozloff, L. M.,; Kočevar, Marijan,; Kraut, J.,; Kumar, A .A.,; Kumar, A. A.,; Kuyper, L. F.,; Kuyper, Lee F.,; Kölb, Hans-Jochen,; Lamey, Philip,; Largilliere, C.,; Lasser, Gerald W.,; Lazarus, Robert A.,; Le Van, Quang,; Leach, M.J.,; Leeming, R.J.,; Lefebvre, Jean,; Leimbacher, W.,; Levine, Robert A.,; Lewis, Garry P.,; Lockhart, Ronan,; Loidl, Peter,; London, Robert E.,; Lovenberg, Walter,; Lue-Shing, Helena,; Lumb, M.,; Lut, Hermann,; Lute, M.,; Lyall, William J.S.,; Lyngbye, Jǿrgen,; Maclntyre, Mary-Frances,; Mager, H. I. X.,; Maley, Frank,; Maley, G. F.,; Maley, Gladys F.,; Mandelbaum-Shavit, Frederika,; Mangum, M.,; Margreiter, R.,; Mark, James E.,; Masada, Masahiro,; Mathews, Christopher K.,; Matsuo, Nobutake,; Matsuura, Sadao,; Matthews, D. A.,; Matthews, Rowena G.,; Mazda, Toshio,; McCairns, E.,; McGing, P.,; McGuire, J. J.,; McMartin, Kenneth E.,; Miller, A. A.,; Miller, Jeffrey B.,; Milstien, S.,; Mizokami, Takashi,; Moffett, Ginnie L.,; Molloy, A.,; Montgomery, John A.,; Morar, C.,; Mueller, W. Thomas,; Ménsua, José Luis,; Nagatsu, Ikuko,; Nagatsu, Toshiharu,; Nair, C. P. P.,; Nair, M. G.,; Nair, M.G.,; Nakazawa, Nobuhiko,; Narasimha Rao, D.,; Nayyir-Mazhir, R.,; Nichol, C. A.,; Nichol, Charles A.,; Nicholson, Sidney H.,; Niederwieser, A.,; Nielsen, Peter,; Niethammer, Dietrich,; Noel, C.,; Noronha, J. M.,; Norrington, F. E.,; North, A. C. T.,; O\x27Donnell, R.A.,; Oates, G. D.,; Ogawa, Hiroshi,; Pallai, Michele,; Parniak, Michael,; Paterson, Richard A.,; Paterson, S. J.,; Paton, Duncan R.,; Paur, Eva,; Pendergast, William,; Perry, Janet,; Peterson, Darrell,; Pfleiderer, Wolfgang,; Pheasant, A. E.,; Pheasant, Α.E.,; Piper, W. N.,; Potterton, E. A.,; Priest, D. G.,; Purohit, Sarla,; Quadros, E.T.,; Rabinowitz, Jesse C.,; Rajagopalan, Κ. V.,; Randies, David,; Rao, Κ. N.,; Redweik, U.,; Reibnegger, G.,; Reibnegger, Gilbert,; Reizer, Jonathan,; Riegelhaupt, Rona,; Roberts, G. C. K.,; Roberts, Gordon C.K.,; Rode, Wojciech,; Rokos, Hartmut,; Rokos, Katharina,; Roland, S.,; Rosenblatt, David S.,; Rosowsky, A.,; Rosowsky, Andre,; Rosowsky, Andrew,; Roth, B.,; Roth, Barbara,; Rothenberg, Sheldon,; Rowe, P. B.,; Rowe, Peter B.,; Rozmyslovicz, Mary K.,; Sadewasser, D.,; Said, Hamid M.,; Sakate, Sakae,; Saleh, A. M.,; Samsonoff, William,; Sargent, R. Geoffrey,; Sauer, D.,; Sauer, Hansjörg,; Sawada, Makoto,; Scanlon, Kevin J.,; Schalhorn, Andreas,; Schirch, LaVerne,; Schlingraann, Gerhard,; Schreiber, C.,; Schwalbe, Carl H.,; Schweiger, Manfred,; Scott, J. M.,; Seydel, J. K.,; Shane, Barry,; Shapiro, Howard M.,; Shapiro, Thomas E.,; Shinozuka, Kazuo,; Sikora, Ewa,; Silva, Francisco,; Singer, S. C.,; Sirotnak, F. M.,; Sirotnak, F.M.,; Slieker, Lawrence J.,; Smith, Gary K.,; Smith, P. L.,; Smithwick, A.,; Spielberger, M.,; Spiro, Craig,; Srinivasan, Ananthachari,; Stammers, D. K.,; Stammers, David K.,; Stanovnik, Branko,; Staudenmann, W.,; Steinberg, Stephen,; Stokstad, E. L. Robert,; Stokstad, E.L.R.,; Stone, D.,; Strum, Williamson B.,; Stupp-Poutot, Gabriele,; Stäben, Chuck,; Suckling, C. J.,; Suckling, Colin J.,; Sueoka, T.,; Sugimoto, Takashi,; Suresh, M.R.,; Susten, S. S.,; Szakolcai, Akos,; Tagawa, H.,; Talente, Edward,; Tang, Kuo-Chang,; Tansik, R.,; Taylor, Edward C.,; Temple, Carroll,; Tišler, Miha,; Tornita, Kazuhiro,; Tse, J.,; Tseng, Chi-Ping,; Tsusue, Motoo,; Vanhille, P.,; Vanoni, Maria A.,; Vestal, K.,; Vie, M. Claude,; Visser, K.,; Vitols, Κ.S.,; Viveros, O. H.,; Viveros, O. Humberto,; Volz, Κ. W.,; Wagner, Conrad,; Wang, Jin-Chen C.,; Wang, M.,; Waring, Paul,; Watkins, David,; Watson, J.E.,; Waxman, S.,; Waxman, Samuel,; Webber, Stephanie,; Weir, D. G.,; Welsh, William J.,; Wetzel, GUnter,; Whitburn, S.B.,; Whitehead, V. Michael,; Whiteley, J. M.,; Whiteley, John M.,; Wick, Michael,; Wiederrecht, Gregory J.,; Wilgus, Harvey,; Wilmanns, Wolfgang,; Wilson, S. P.,; Wobbe, C. R.,; Wood, Hamish C. S.,; Wood, Hamish C.S.,; Wright, J. E.,; Wright, Joel E.,; Wächter, H.,; Wächter, Helmut,; Yamada, S.,; Yamaguchi, Tokio,; Yanagisawa, Mariko,; Yim, John J.,; Yoshida, Takeo,; Yoshioka, Shin\x27ichi,; Young, Douglas W.,; Zakrzewski, Sigmund F.,; Ziegler, Irmgard,; Ζieger, Irmgard,; Ζ¡eger, Irmgard,
• HerausgeberIn: Blair, John A.,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2015]; ©1983
• Year of Publication: 2015
• Edition: Reprint 2014
• Language: English
• Series: Chemistry and Biology of Pteridines ; 7
• Physical Description: 1 online resource (1070 p.) :; Zahlr. Abb.

Table of Contents

Frontmatter -- Preface -- ACKNOWLEDGEMENTS -- PARTICIPANTS -- Contents -- The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds -- Chemical Aspects (1) -- Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products -- Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins -- The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones] -- Some Simple s-Triazolopteridines -- Linear Tricyclic Analogs of Pteridines -- Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis -- Syntheses of some Blocked 7,8-Dihydropteridines -- Synthesis of Chiral Reduced Pteridine Coenzymes -- Report on Discussions -- Chemical Aspects (2) -- Reactivity of Pteridines -- Synthesis and Antitumor Activity of 10-Deazaminopterins -- Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin -- The Nor-Analogues of Folic Acid -- Report on Discussions -- Neurochemical and Clinical Aspects -- Metabolism of Pteridine Cofactors in Neurochemistry -- Pteridines in Cancer and Other Diseases -- Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing -- A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSE -- Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate -- Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis -- Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia -- Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers -- Report on Discussions -- Enzymology -- The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase -- Catalytic Site of Dihydrofolate Reductase -- Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase -- Methylene Tetrahydrofoíate Reductase: Studies in a Human Mutant and Mammalian Liver -- Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine -- Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis -- The Mechanism of Action of the Transformylase Enzymes -- Folypolyglutamate Synthesis in Neurospora Crassa -- Report on Discussions -- Clinical Aspects: Cancer -- Folates and Cancer Chemotherapy -- Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells -- A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells -- Further Characterization of the Pterdine Binding Variant of Alphas-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases -- Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates -- Attempts to Design Inhibitors of Dihydrofolate Reductase Using Interactive Computer Graphics with Real Time Energy Calculations -- Control of Methotrexate Polyglutamate Synthesis in Cultured Rat Hepatoma Cells -- Differential Effects of Methotrexate or Fluorodeoxyuridine upon Mitochondrial and Cellular Nucleotide Pools -- Report on Discussions -- Bioorganic Chemistry and Enzymology -- Chemical Mechanisms in the Action of Pteridine Coenzymes -- Irreversible Inactivation of Rat Liver Phenylalanine Hydroxylase by Reaction with (6S)-L-Erythro-Tetrahydrobiopterin -- p-Azidophenylalanine: A Potential Photoaffinity Probe for Rat-Liver Phenylalanine Hydroxylase -- Pyrimidine Models for the Cofactor of Phenylalanine Hydroxylase -- Activation of Molecular Oxygen by Tetrahydropterin Monooxygenases -- Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates -- Properties of Thymidylate Synthase from Streptococcus Faecium -- Cloning the Gene for Eukaryotic C1-THF Synthase -- Report on Discussions -- Biochemistry and Biology -- The Enzymatic Synthesis of the Drosopterins: Identification of a Pyrimidodiazepine as an Intermediate -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis -- The Role of Pteridines in Regulation of Growth -- Evidence for a Folate Bound to Rat Hepatic Uroporphyrinogen III Cosynthase and its Role in the Biosynthesis of Heme -- Report on Discussions -- Presented Papers -- Aerobic Oxidation of 5,6,7,8-Tetrahydroneopterin -- The Conformations of 7,8 (6H)-Dihydropterin Substrates and the Activity of Dihydropteridine Reductase (E.C.1.6.99.10) -- Dihydrofolate Reductase: The Stereochemistry of Inhibitor Selectivity -- Synthesis of an 8-Deaza Analog of the Intermediate in the Thymidylate Synthetase Reaction (1) -- The Synthesis of Analogs of Pteroylglatamyl-y-Phosphate as Potential Inhibitors of Folylpolyglutamate Synthetase -- Synthesis and Activity of 8,10-Dideazaminopterin -- CNDO/2 Molecular Orbital Calculations on the Antifolate DAMP and Some of its Analogues: Conformational Characteristics -- Fluorescent Analogues of Methotrexate as Probes for Folate Antagonist Molecular Receptors -- Dihydrofolate Reductase Overproduction Identified by Flow Cytometry Using a Fluorescent Methotrexate Analogue -- New Syntheses and Transformations of Some Pteridines and Pteridine 3-Oxides -- Photooxidation of Mercaptopteridines -- Reactivity of 6,7-Dichloro-1, 3-Dimethyllumazine -- Synthesis, Reactivity and Properties of 8-Substituted 2-Thio- and 2,4-Dithiolumazines -- The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures -- Structural Studies of Antifolate Drugs -- Isolation and Characterization of a Novel Folate Antagonist -- Synthesis and Biological Properties of the S-8 Analog of 7,8-Dihydropteridinealcohol -- Synthesis of Dihydrobiopterin from Dihydroneopterin Triphosphate in Rat Tissues and Human Blood Corpuscles: Diagnosis of Atypical Phenylketonuria due to Biopterin Deficiency by Assay of an Enzyme Involved in the Synthesis -- Stereospecific Enzyme Mediated Syntheses of Tetrahydrofolate Derivatives -- Immobilization of Dihydrofolate Reductase from Amethopterin Resistant Lactobacillus Casei -- X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase -- A New Spectrophotometry Method for the Assessment of Tight Binding Benzyldiaminopyrimidine Inhibitors of Dihydrofolate Reductase -- Two Interconverting Conformers of a Drug-Receptor Complex: The Lactobacillus Casei Dihydrofolate Reductase-NADP+ - Trimethoprim Complex -- Multiple Conformations of the Dihydrofolate Reductase- Folate-NADP+ Complex -- The Three-Dimensional Structure of Mouse L1210 Dihydrofolate Reductase -- Isolation and Amino Acid Sequence Studies of Dihydrofolate Reductase from Neisseria Gonorrhoeae -- Purification of 7,8-Dihydropteroate-Synthetase from E. Coli by Affinity- and Hydrophobic Interaction Chromatography -- Isolation and Characterization of an E.

Coli Mutant Affected in Dihydrofolate- and Folylpolyglutamate- Synthetase -- Purification and Properties of 5-Formyltetrahydrofolate Cyclodehydrase from Rabbit Liver -- Structural Studies on Formyl-Methenyl-Methylene Tetrahydrofolate Synthetase from Rabbit Liver -- Utilization of Folate Polyglutamate for Growth by Lactobacillus Casei -- Folate and Folate Enzymes as Structural Components of Bacteriophage Particles -- Studies on the Substrate Specificity of Mammalian Folylpolyglutamate Synthetase -- Properties of Corynebacterium Species Dihydrofolate Synthetase-Folylpolyglutamate Synthetase -- Purification and Characterization of Folylpolyglutamate Synthetase from Lactobacillus Casei and Hog Liver -- The Molybdenum Cofactor from Xanthine Oxidase: Quantitative Assay of the Molybdenum Cofactor by Activation of Nitrate Reductase Activity in Extracts of the Nit-1 Mutant of Neurospora crassa -- Structural Studies of Calf Thymus Thymidylate Synthase -- A Comparison of the T-Even Phage Induced and Escherichia Coli Thymidylate Synthases -- Thermophilicity of Dihydrofolate Reductase and Thymidylate Synthetase from a Thermophilic Microorganism -- Chemical Characterization of Two Folate-Binding Proteins from Mitochondria: Dimethylglycine Dehydrogenase and Sarcosine Dehydrogenase -- Allosteric Mung Bean (Vigna radiata) Serine Hydroxylmethyl-Transferase -- Comparative Study of the Eye Colour Mutants of Drosophila Melanogaster: Quantification of the Eye-Pigments and Related Metabolites -- Studies on Sepialumazine, the Characteristic Larval Integument Pigment of the Bombyx Mori Kiuki Mutant -- Macromolecular Regulation of Sepiapterin and Drosopterin Synthesis in the Purple Mutant of Drosophila -- The Hydroxylation of Phenylpropanoids by Euglena gracilis : Role of Pteridines -- Studies with Old Yellow Enzyme, Reconstitution with Lumazine Analogs as Coenzyme -- Biosynthesis of Riboflavin -- Biosynthesis of Riboflavin -- Metabolism and Function of Pterin Compounds in Seed Germination -- Thymidylate Synthetase During Proliferation and Differentiation of Physarum polycephalum -- Influence of Vitamin B12 on Folate Metabolism in Lactobacillus Leichmannii -- High-Affinity Binding of Folate to a Small and Large Molecular Size Protein from Human Milk -- High-Affinity Folate Binding in Leukocytes from Normal Subjects Displays Positive Cooperativity, and the Affinity Depends on the Protein Concentration -- Characteristics of 5-Methyltetrahydrofolate Binding to the Folate-Binding Protein from Cow's Whey -- Interactions of Folate-Dependent Enzymes of DNA Precursor Metabolism in T4 Phage-Infected Bacteria -- The Regulation of Biopterin Biosynthesis in the Rat -- Biosynthesis of Tetrahydrobiopterin in Mammalian Tissues by De Novo and Salvage Pathways -- Perspectives on Tetrahydrobiopterin Biosynthesis in Mammals -- Human Dihydropteridine Reductase (DHPR) Deficiency -- Coordinate Regulation of Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Adrenal Medullary Chromaffin Cells -- Regulation of Adrenocortical Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Normal and Spontaneously Hypertensive Rats -- Inhibition of Brain Sepiapterin Reductase by a Catecholamine and an Indoleamine -- Mouse Mastocytoma Tryptophan Hydroxylase: Role of Iron and Catalase in the Expression of Enzyme Activity after Activation by Anaerobic Preincubation with Dithiothreitol -- Folic Acid Induced Kindling in Rats: Changes in Brain Amino Acids -- Impaired Pteroylpolyglutamate Synthesis in the Cobalamin-Inactivated Rat -- A Radioimmunoassay for Determination of D-Erythro- Neopterin -- Radioimmunoassay for Neopterin in Body Fluid and Tissues -- A Specific Antiserum Against Tetrahydrobiopterin: Its Preparation and Application to Immunohistochemistry -- Speculation on the Mechanism of Therapeutic Action of Tetrahydrobiopterin in Human Disease -- Correlation of Tetrahydrobiopterin Content and Guanosine Triphosphate Cyclohydrolase Activity in Cells and Tissues -- Unconjugated Pteridines in Human Physiological Fluids. Normal and Pathological Profiles -- Biopterin and Phenylalanine Metabolism During Early Liver Regeneration -- GTP-Cyclohydrolase Activities in Rat Liver -- Phenylalanine Hydroxylase Assay Using Biopterin and Synthetic Pteridine -- Dihydropteridine Reductase Levels in Human Normal and Neoplastic Tissues -- Investigations of Tissue Folates in Normal and Malignant Tissues -- Blood Cell Biopterin as an Indicator of Transplanation- Induced Hemopoiesis and Leukemic Cell Proliferation -- Assessment of Urinary Neopterin in the Early Diagnosis of Human Allograft Rejection -- Behaviour of Neopterin Levels in Patients with Haematological and Gynaecological Neoplasms -- Pteridines in Dictyostelium discoideum and Physarum polycephalum -- Biochemical and Chemotherapy Studies on BW 301U, a Novel Lipophilic 2,4-Diaminopyridopyrimidine Antifolate -- Toxicity of a Series of Antifolate Compounds in a Methotrexate-Resistant Celi Line -- Interaction of Methotrexate Poly(L-Lysine) with Transformed Hepatic Cells in Culture -- A Novel Technique for Producing Folate-Deficient Hepatica Cells -- Methotrexate Metabolism in Acute Lymphoblastic Leukemia -- Altered Methotrexate Sensitivity in Human Leukemic K562 Amino Acid Transport Mutant Cells -- Methotrexate and Methotrexate Polyglutamates in Erythrocytes After High-Dose Methotrexate -- Methotrexate Polyglutamates in Human Fibroblasts: Reversal of Antifolate Cytotoxicity -- Human Cells Resistant to Methotrexate: Cross Resistance and Collateral Sensitivity to the Nonclassical Antifolates Trimetrexate, Metoprine, Homofolic Acid and CB3717 -- Homology of Two Forms of Dihydrofolate Reductase in Human Leukaemic and L1210 Cells During Expression of Resistance to Methotrexate -- Adaptation of Folylpolyglutamates to Folate Deprivation in Mouse Hepatoma Cells -- Utilization and Loss of Reduced Folates by Human Fibroblasts in Vitro -- Factors Affecting Folate Polyglutamate Biosynthesis in Rat Liver -- Differential Binding of Folates but not Methotrexate (MTX) by Brush Border (BB) and Basal Lateral (BL) Membranes of Rat Renal Cortex -- Biosynthesis of Folate Derivatives in Ehrlich Ascites Carcinoma Cells Grown in Mice and in some Organs of the Host -- Variability of Thymidylate Synthetase in Ehrlich Carcinoma Cells and its Role in Resistance to 5-Fluorodeoxyuridine -- One-Carbon Metabolism in Human Lymphocytes -- Possible Mechanisms of Folate Catabolism -- The Intracellular Folate Pool: Studies of Kinetics and Functional Significance -- Intestinal Folate Transport. A pH-Dependent, Carrier- Mediated Process -- Effects of Folate Depletion on Growth and Survival of Human Cell Line K-562 in Culture -- Alterations in Folate Metabolism of the Rat Induced by Acute Ethanol Administration -- Participation of Pterins in the Control of Lymphocyte Transformation and Lymphoblast Proliferation -- The Pterin Component of the Molybdenum Cofactor (Molybdopterin): Relationship to Urothione -- Report on Presented Papers -- Author Index -- Subject Index -- Backmatter