Concepts in Vaccine Development / / ed. by Stefan H. E. Kaufmann.
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Table of Contents:
- Frontmatter
- Preface
- Bicentennial of the first vaccination by Edward Jenner
- Contents
- 1. The Need for New Vaccines
- 1.1. Vaccines as Evolutionary Tools: The Virulence-Antigen Strategy
- 1.2. Economic Perspectives on Vaccine Needs
- 1.3. Future Immunization Strategies – Considerations from the Public Health View
- 1.4. The New Pertussis Vaccines
- 2. General Principles of Immunology
- 2.1. Basic Principles of Immunity Against Intracellular Bacteria and Protozoa
- 2.2. Viral Immunity and Vaccine Strategies
- 2.3. Broadly Reactive HLA Restricted Τ Cell Epitopes and Their Implications for Vaccine Design
- 2.4. Quantitative Considerations in the Design of Vaccination Strategies Against Pathogens Uniquely Susceptible to Cell-Mediated Attack
- 2.5. The Impact of the Type 1 and Type 2 Τ Helper Cell Concept on Novel Vaccine Design with Emphasis on Protection Against Leishmania Parasites
- 3. General Principles of Vaccinology
- 3.1. Modern Adjuvants. Functional Aspects
- 3.2. Biodegradable Microspheres as Vehicles for Antigens
- 3.3. Peptide Based Vaccines
- 3.4. Recombinant Bacteria as Vaccine Carriers of Heterologous Antigens
- 3.5. Genetic Detoxification of Bacterial Toxins
- 3.6. Recombinant Virus as Vaccination Carrier of Heterologous Antigens
- 3.7. Naked DNA Vaccination
- 3.8. Oral Vaccination, Mucosal Immunity and Oral Tolerance with Special Reference to Cholera Toxin
- 4. Specific Vaccination Strategies
- 4.1. Helicobacter pylori: Pathogenic Determinants and Strategies for Vaccine Design
- 4.2. Malaria Vaccination
- 4.3. Vaccination Against Schistosomiasis: Concepts and Strategies
- 4.4. AIDS Vaccination
- 4.5. Vaccination Therapy Against Autoimmune Diseases
- Contributors
- Index
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