Vitamin D : : A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 / / ed. by Anthony W. Norman, Monique Thomasset, Roger Bouillon.
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Table of Contents:
- Frontmatter
- FOREWORD
- Official Sponsors and Donors
- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D
- Vitamin D Workshop. Career Recognition Awardees
- Contents
- Chemistry of Vitamin D
- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation
- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships
- Chemical Conversion of Vitamin D3 to Calcitriol Lactone
- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol
- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses
- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs
- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions
- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers
- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs
- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3
- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3
- Structure-Activity Studies of Fluorinated Vitamin D Analogs
- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion
- Synthesis of 24-Hydroxy-Vitamin D Analogues
- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3
- A New Route to the Vitamin D Triene System
- Studies on the Synthesis of 19-Norprevitamin D3 Analogues
- Structure/Function Studies of Vitamin D Steroids
- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications
- Future Prospects for Vitamin D Analogs
- Chemistry and Biology of 22,23-yne Analogs of Calcitriol
- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity
- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells
- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs
- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues
- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton
- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto
- New Discoveries in Vitamin D Related Compounds
- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility
- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region
- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues
- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues
- 20-Methyl Vitamin D Analogues
- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results
- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs
- Vitamin D Binding Protein
- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues
- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum
- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues
- Vitamin D Hydroxylases: Biochemistry and Regulation
- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine
- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase
- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain
- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene
- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats
- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1
- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver
- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria
- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy
- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis
- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients
- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1)
- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats
- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate
- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues
- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase
- Vitamin D Metabolism and Catabolism
- Target Cell Metabolism of Vitamin D and its Analogs
- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin
- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes
- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells
- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82
- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3
- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate
- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney
- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes
- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific
- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line
- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells
- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells
- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes
- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry
- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs
- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts
- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta
- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny
- Receptors for 1a,25(OH)2D3
- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation
- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization
- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone
- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D
- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers
- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription
- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements
- Immunohistochemical Localization of 1,25-Dihydroxy
- vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas
- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8)
- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats
- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization
- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library
- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor
- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type
- Gene Regulation
- 1,25(OH)2D3 Response Elements: Is There an Order?
- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation
- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3
- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements
- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses
- A Novel Vitamin D Response Element in the Murine c-fos Promoter
- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines
- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA)
- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein
- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo
- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells
- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells
- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription
- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines
- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin
- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different
- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3
- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene
- Rapid Actions of Vitamin D Steroids
- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts
- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences
- Nongenomic Effects of Vitamin D
- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3
- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol
- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells
- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei
- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes
- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3
- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3
- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts
- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells
- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes
- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes
- Calbindins D—Function and Gene Regulation: Calcium Transport
- Mechanistic Studies on Intestinal Ca2 + Transport
- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins
- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones
- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor
- Studies of the Human Calbindin-D9K Gene
- Calbindins Revisited in the Rat Dental Pulp
- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts
- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture
- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells
- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC)
- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs
- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells
- Does Calbindin-D28K Buffer Intracellular Free Calcium?
- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3
- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells
- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K
- Effect of Antisense Sequences Against Calretinin on WiDr Cells
- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment
- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua
- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption
- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms
- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum
- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney
- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat
- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker
- Cell Differentiation
- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines
- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis)
- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro
- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects
- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation
- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts
- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß
- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation
- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts
- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices
- Cancer
- Immunology
- Dermatology
- Neurosciences
- Renal Osteodystrophy
- Bone and Cartilage
- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs
- Assays for Vitamin D Steroids
- Nutrition
- Osteoporosis
- Neonatology and Pregnancy
- Gerontology
- Other Basic Science Topics
- Other Clinical Topics
- Author Index
- Subject Index
- Cell Line Index
- Zoo Index
- Backmatter
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