Vitamin D : : A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 / / ed. by Anthony W. Norman, Monique Thomasset, Roger Bouillon.
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| Other title: | Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of 1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Osteoporosis -- Neonatology and Pregnancy -- Gerontology -- Other Basic Science Topics -- Other Clinical Topics -- Author Index -- Subject Index -- Cell Line Index -- Zoo Index -- Backmatter |
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| Format: | Mode of access: Internet via World Wide Web. |
| ISBN: | 9783110882513 9783110637335 |
| DOI: | 10.1515/9783110882513 |
| Access: | restricted access |
| Hierarchical level: | Monograph |
| Statement of Responsibility: | ed. by Anthony W. Norman, Monique Thomasset, Roger Bouillon. |
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