Fibrinogen. Proceedings/ Workshop on Fibrinogen. / Vol. 4, : Fibrin formation and Fibrinolysis ; April, 2–3, 1985, London, England / / hrsg. von D. A. Lane.

• Superior document: Title is part of eBook package: De Gruyter DGBA Medicine and Life Sciences - <1990
• MitwirkendeR: Beck, Eugene A.,; Bernadou, A.,; Bertrand, O.,; Blobel, H.,; Bode, W.,; Bonnet, P.,; Boucheix, C.,; Brommer, E.J.P.,; Caen, J.P.,; Chhatwal, G.S.,; Coccheri, S.,; Colella, S.,; Dejana, E.,; Delvos, U.,; Desvignes, P.,; Douglas, J.T.,; Dunn, F.W.,; Eastham, R.,; Elwood, P.C.,; Engbers, J.,; Erroi, A.,; Etherington, M.D.,; Forbes, C.D.,; Fuhge, P.,; Furlan, Miha,; Gabrijelčič, D.,; Gaffney, P.J.,; Gilmour, R.A.,; Ginsberg, M.H.,; Gollwitzer, R.,; Graeff, H.,; Hafter, R.,; Handley, D.A.,; Haverkate, F.,; Heimburger, N.,; Henschen, A.,; Henschen, Agnes,; Hugo, R. von,; Huijsmans, C.M.G.,; Ireland, Helen,; Jasani, M.K.,; Jayson, M.I.V.,; Kaudewitz, H.,; Keegan, A.,; Kehl, Maria,; Keyser, J.,; Knight, I.,; Knight, Irina,; Koopman, J.,; Koppert, P.,; Koppert, P.W.,; Kudryk, Bohdan,; Kulbe, G. E.,; Lane, D.A.,; Lane, David A.,; Languino, L.R.,; Leekstna, O.C.,; Lijnen, H.R.,; Linke, R. P.,; Liu, C.Y.,; Lowe, G.D.O.,; Maes, Luk,; Mantovani, A.,; Manucci, Piero M.,; Marguerie, G.,; Meijer-Huizinga, F.M.,; Million, R.,; Mirshahi, M.,; Miyada, D.,; Mourik, J.A. van,; Müller, E.,; Müller-Berghaus, G.,; Nieuwenhuizen, W.,; O’Brien, J.R.,; Palareti, G.,; Perrot, J.Y.,; Perry, M.J.,; Peters, R.F.,; Pirkle, H.,; Plow, E.F.,; Poggi, M.,; Pountain, G.,; Preissner, K.T.,; Prydz, Hans,; Rampling, M.W.,; Reber, Peter,; Redman, Colvin,; Rupp, Christoph,; Rötker, J.,; Samama, M.,; Scheefers-Borchel, U.,; Schröck, R.,; Schubring, C.,; Selmayr, E.,; Smith, Elspeth B.,; Soria, C.,; Soria, J.,; Southan, Christopher,; Svenson, E.,; Sweetnam, P.M.,; Takada, A.,; Takada, Y.,; Talbot, M.D.,; Theodor, I.,; Thiel, W.,; Thomaïdis, A.,; Thompson, Elizabeth,; Tomlinson, I.,; Tweed, M.F.,; Vukasin, P.,; Walker, Joyce E.,; Wallen, P.,; Weimar, B.,; Werf, W.G.C. van der,; Yarnell, J.W.G.,; Yu, Sharon,
• HerausgeberIn: Lane, D. A.,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2019]; ©1986
• Year of Publication: 2019
• Edition: Reprint 2019
• Language: German
• Series: Fibrinogen. Proceedings/ Workshop on Fibrinogen ; Vol. 4
• Physical Description: 1 online resource (396 p.) :; Num. figs.

Table of Contents

Frontmatter -- Preface -- Contributors -- Contents -- I. Synthesis And Assembly -- A scheme for the intracellular assembly of human fibrinogen -- Evidence that platelet and plasma fibrinogen have the same A-alpha chain gene product -- Fibrinopeptide A and the phosphorylation of fibrinogen -- II. Structure and Function -- Size and shape of the fibrinogen molecule: crystalline forms of native and modified human fibrinogen -- The C-terminal polymerisation domain of fibrinogen -- γ- Chain Crosslinking Of Fibrin At Dd-Trans Contact -- Soluble fibrin contains fibrin polymers of different molecular weight. Ultracentrifugation studies at 37°C -- Relationship of final thickness of fibrin fibers to maximal rate of assembly and to fibrinopeptide B release -- III. Congenital Variants -- Fibrinogen New York 1: The structural, functional, and genetic defects and an hypothesis of the role of fibrin in the regulation of coagulation and fibrinolysis -- Fibrinogen Pontoise - a genetically abnormal fibrinogen with defective fibrin polymerisation but normal fibrinopeptide release -- Fibrinogen Milano I: Abnormal fibrin polymerization related to a carboxy-terrainal defect of the γ-chain (γ-330 Asp Val) -- Fibrinogen "Bergamo I" (Λα 16 Arg - Cys): Alternative methods for structure elucidation -- Screening small plasma samples by HPLC for abnormalities of fibrinopeptide release -- Iv. Fibrin(ogen) And Fibrinolysis -- On the role of fibrin in the fibrinolytic system -- Isolation and characterisation of plasmic degradation products of fibrinogen by high-performance liquid chromatography -- The acceleration of tissue-type plasminogen activator (t-PA)-mediated activation of plasminogen by fibrinogen cyanogen bromide fragments is species specific -- Role of fibrin polymerization in fibrinolysis: Comparison between polymerisable and unpolymerisable fibrins in the potentiating effect of plasminogen activation by tissue-type plasminogen activator (tpA) -- Role of fibrin and its degradation products in the activation of plasminogen by streptokinase and urokinase -- V. Interactions With Cells -- The role of fibrinogen in platelet aggregation -- Platelet-associated fibrinogen: Conformational change of fibrinogen induced by its adsorption to platelet-surface -- Migration of cultured endothelial cells in response to fibrinogen -- Characteristics of the interactions of fibrinogen and soluble fibrin with cultured endothelial cells -- Mechanism of fibrin-induced disorganisation of cultured human endothelial cells -- The fibrinogen: red cell interaction and its influence on blood rheology -- Haemorheologic effects of plasmin and thrombininduced fibrinogen derivatives: An in vitro study -- Binding of human fibrinogen to streptococci and its role in streptococcal pathogenicity -- VI. Assays To Fibrin(ogen) Fragments And Their Use -- Discrimination between fibrin and fibrinogen by a monoclonal antibody against a synthetic hexapeptide representing the amino-terminus of the alpha-chain of fibrin -- A new enzyme immunoassay of fibrin(ogen) degradation products in plasma using a monoclonal antibody -- Fibrin(ogen) degradation products. Determination using a monoclonal anti D neo antibody. Advantages in clinical investigation -- A monoclonal antibody, specific for human fibrinogen and fibrinopeptide A-containing fragments. Its application in an enzyme-immunoassay for fibrinogen degradation products, suitable for use in plasma -- A monoclonal antibody against the CNBr-peptide F-CB3 of the Aα-chain of human fibrinogen -- Clinical aspects of fibrin formation and fibrinolysis measured with monoclonal antibodies against D-dimer -- Fibrinogen derivatives in acute stroke -- VII. Fibrin(ogen) And Disease Pathology -- Triggering of the extrinsic blood coagulation system -- Extravascular fibrin formation and fibrinolysis in a model of inflammation accompanying cellular hypersensitivity -- Extra-vascular fibrin deposition in cellular hypersensitivity - the role of T lymphocyte-macrophage interactions -- Fibrinolytic studies in disorders of connective tissue -- Soluble fibrin/fibrinogen related antigen in human intima in relation to atherogenesis -- Fibrinogen as a possible risk factor for IHD in the Caerphilly study -- VIII. Appendix: Data On Fibrinogen -- Fibrinogen amino acid sequences -- Author Index -- Subject Index -- Backmatter