The Roots of Modern Biochemistry : : Fritz Lippmann's Squiggle and its Consequences / / ed. by Hans von Döhren, Horst Kleinkauf, Lothar Jaenicke.

• Superior document: Title is part of eBook package: De Gruyter DGBA Medicine and Life Sciences - <1990
• MitwirkendeR: Agustin, Jovenal San,; Akers, H.A.,; Allende, Jorge E.,; Anderson, B.,; Anke, T.,; Ase, K.,; Auer, Bernhard,; Babloyantz, A.,; Baddiley, James,; Bakker, Evert P.,; Baltscheffsky, Herrick,; Baltscheffsky, Margareta,; Barker, H.A.,; Bauer, Karl,; Baxter, Ross M.,; Bennett, Thomas Peter,; Bessman, Samuel P.,; Blaschko, Η.,; Bloch, Konrad,; Brot, Nathan,; Buchanan, John M.,; Coleman, Timothy,; Coronel, Carlos,; Delbrück, A.,; Dimroth, Peter,; Duine, J. A.,; Dunn, Lily,; Duve, Christian de,; Döhren, Hans von,; Ebashi, Setsuro,; Fehr, Susanne,; Fei, Le,; Finver, S.,; Fox, J. Lawrence,; Fox, Sidney W.,; Fruton, Joseph S.,; Fujii, T.,; Ganoza, M. Clelia,; Gevers, Wieland,; Goldberg, Irving H.,; Goldblatt, D.,; Grisolia, S.,; Gurr, E.,; Hadjiolov, A.A.,; Heber, Ulrich,; Hernández-Yago, J.,; Herrlich, Peter,; Herrmann, Heinz,; Herzog, Herbert,; Hierowski, Marion T.,; Hilz, H.,; Hirsch-Kauffmann, Monica,; Hiskes, Anne L.,; Hoch, F. L.,; Horecker, B.L.,; Igarashi, K.,; Ikeuchi, Toshihiko,; Jagow, G. von,; Jencks, William P.,; Kaiser, Georg,; Kaiser, Werner M.,; Kaji, A.,; Kalckar, Herman Μ.,; Karin, Michael,; Karlson, Peter,; Kaufman, S.,; Kaufmann, Elaine E.,; Kikkawa, U.,; Kleinkauf, Horst,; Klocker, Helmut,; Knecht, E.,; Krampitz, Lester O.,; Krebs, Hans A.,; Kubota, Kou,; Kudoh, Jun,; Kurahashi, Kiyoshi,; Kurokawa, T.,; Kućan, Željko,; Lane, B.G.,; Lanyi, Janos Κ.,; Lara, F.J.S.,; Lardy, Henry,; Lees, Marjorie B.,; Lipmann, Freda Hall,; Lipmann, Fritz,; Liu, Ming-Cheh,; Lundin, Maria,; Maas, Werner K.,; Martinoia, Enrico,; Maruyama, Koscak,; Maxon, Mary E.,; McDonald, Michael W.,; McElroy, W.D.,; Meyerhof, Wolfgang,; Mohan, Chandra,; Mohr, Evita,; Mommaerts, Wilfried F. Η. Μ.,; Moore, Τ. K.,; Mori, K.,; Morley, Steven D.,; Moulton, L.J.,; Mukai, Jun-Ichiro,; Najjar, V.A.,; Neupert, Walter,; Nishizuka, Y.,; Nomura, Masayasu,; Nyrén, Pål,; Ogawa, Yasuo,; Ogita, K.,; Okawa, N.,; Ono, Y.,; Park, C. R.,; Park, Jane Harting,; Parthier, Β.,; Peck, Harry D.,; Petrack, Barbara,; Pfanner, Nikolaus,; Racker, Efraim,; Rapoport, S.M.,; Ratner, Sarah,; Redfield, Betty,; Richter, Dietmar,; Roskoski, Robert,; Saito, N.,; Scherzer, Elisabeth,; Schmale, Hartwig,; Schneider, Rainer,; Schramm, G.,; Schweiger, Manfred,; Seger, R.,; Shaltiel, S.,; Shearman, M.S.,; Shoeman, Robert L.,; Siekevitz, Philip,; Slater, E.C.,; Spirin, Alexander S.,; Srere, Paul A.,; Steglich, W.,; Suiko, M.,; Suiko, Masahito,; Sullivan, Jerry W.,; Sy, J.,; Tamai, Y.,; Tanaka, C.,; Tanaka, M.,; Tao, Mariano,; Thurnher, Martin,; Ting-chung, Zhou,; Toyoda, Y.,; Vosberg, Hans-Peter,; Wagner, Erwin F.,; Weissbach, Herbert,; Wieland, Th.,; Witt, H. T.,; Wittmann, H.G.,; Wood, Harland G.,; Yonath, A.,; Zachau, Hans G.,; Zhao-geng, Zhang,; Zubay, Geoffrey,
• HerausgeberIn: Döhren, Hans von,; Jaenicke, Lothar,; Kleinkauf, Horst,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2011]; ©1988
• Year of Publication: 2011
• Edition: Reprint 2011
• Language: English
• Physical Description: 1 online resource (994 p.) :; Num. figs.

“The Roots of Modern Biochemistry is a superb introduction into modern biochemistry, much recommended as initial overview of the subject.” Prof. Dr. Hans Fritz, Ludwig-Maximilians-University Munich

„The Roots of Modern Biochemistry ist eine gute Einführung in die moderne Biochemie, und als Einstieg sehr zu empfehlen.” Prof. Dr. Hans Fritz, Ludwig-Maximilians-Universität München

Table of Contents

I-VI -- Preface -- Contents -- 1. Fritz Lipmann (1899-1986) -- 1. Fritz Lipmann (1899-1986) -- Life with Fritz -- A Long Life in Times of Great Upheaval -- Fritz Lipmann: In Memoriam -- Lipmann's Remarkably Fulfilled Life as a Researcher -- Fritz Lipmann: June 12, 1899 - July 24, 1986 -- Fritz Lipmann Molding the Design of Molecular Bioenergetics -- Recollections of Fritz Lipmann, 1941-1945 -- In Celebration of the Scientific Genius of Fritz Lipmann -- Lipmann and "Not Strictly Biochemistry" -- Communication in Metabolic Control Intuition and Method in Biochemistry: Four Years each with Krebs and Lipmann -- Fritz Lipmann: Squiggle to Protein Sulfation -- Fritz Lipmann (1899-1986), Honorary Member of the Leopoldina Academy -- Dahlem in the Late Nineteen Twenties -- Our Apprenticeship -- The Kaiser-Wilhelm-Institutes in Berlin-Dahlem in the Late 1930ies and Early 1940ies: Reminiscences of a Student of Biochemistry -- On the Origin of the Squiggle (~) -- 2. Biochemistry Comes of Age -- 2. Biochemistry Comes of Age -- The History of Metabolites Isolated from Urine -- The Pentose Phosphate Pathway -- Glycolysis and the Dawn of Modern Biochemistry -- Energy-Rich Bonds and Enzymatic Peptide Synthesis -- A Nostalgic View of the TCA Cycle in Bacteria -- The Role of Vitamins and their Carrier Proteins in Citrate Fermentation -- Lipmann's Influence on Firefly Luminescence -- Sulfur in Biomimetic Peptide Syntheses -- The Function of Teichoic Acids in Walls and Membranes of Bacteria -- The Amidotransferases: Origins of the Concept of Affinity Labeling of Enzymes -- Intracellular Protein Degradation: Past, Present and Future -- Lipmann's Squiggle and the Unification of Cellular Structure and Function -- The Historical Intermingling of Biochemistry and Cell Biology -- Regulation of Function of Membrane Proteins by Phosphorylation and Dephosphorylation -- Molecular Biology of Brain Peptides and their Cognate Receptors -- The Biological Activity of Tuftsin, Thr-Lys-Pro-Arg -- Biosynthesis of Linear Gramicidin, Pentadeca Peptide, is Tight Linked to Serine Metabolism and to Membranous Phosphoglyceride -- From Phosphoenolpyruvate Carboxykinase to Sporulation: Personal Reflections on Dr. F. Lipmann -- Research on Nonribosomal Systems: Biosynthesis of Peptide Antibiotics -- Metabolism of Carnosine and Related Peptides -- 3. Molecular Biology Sharpens its Tools -- 3. Molecular Biology Sharpens its Tools -- DNA Repair in Human Cells: Molecular Cloning of cDNAS Coding for Enzymes Related to Repair -- Acyl ~ Phosphate Intermediates in Oxidative DNA Sugar Damage by Antibiotics -- Rts1: A Multiphenotypic, Unusual Temperature Sensitive Drug Resistance Factor -- The Partial Dependency of Human Prostatic Growth Factor on Steroid Hormones in Stimulating Thymidine Incorporation into DNA -- Developmentally Regulated Gene Amplification in Rhynchosciara -- Fritz Lipmann, a Few Personal Memories, and: What Else Came Out of the High-Energy Phosphate Bond? -- Regulation of Gene Expression by Posttranslational Modification of Transcription Factors -- How Does the Arginine Repressor Regulate the Synthesis of Arginine Biosynthetic Enzymes? -- The Biochemistry and Molecular Biology of the Terminal Reactions of Methionine Biosynthesis in Escherichia coli -- The Wheat Embryo, Then and Now -- Mechanism of Cytotoxic Action and Structures of Thiadiazolo-pyrimidines -- Architecture of Ribosomal Particles as Investigated by Image Reconstruction and X-Ray Crystallographic Studies -- Initiation of Protein Synthesis: Early Participation and Recent Revisit -- Structure of Ribosomal RNA Genes of Eukaryotes: Some Solved and Unsolved Questions -- Energetics and Dynamics of the Protein- Synthesizing Machinery -- Expression -- Punctuation in the Genetic Code: A Plausible Basis for the Degeneracy of the Code to Initiate Translation -- Reconstruction of Translation: Role of EF-P in Regulation of Peptide Bond Formation -- On the Role of Spermine in Protein Synthesis -- 4. Functional Dynamics -- 4.1 The Squiggle - Symbol of Bioenergetics -- 4.1 The Squiggle - Symbol of Bioenergetics -- Energy-Rich Compounds and Work -- Squiggle Phosphate of Inorganic Pyrophosphate and Polyphosphates -- Enzymology of 3'-Squiggled Nucleotides -- Pyridine Nucleotides as Group Transfering Coenzymes -- The Nature of Squiggle in Oxidative Phosphorylation -- Motional Dynamics of Fatty Acids: Advantages of 15N and Deuterium Substituted Fatty Acid Spin Labels for Studies of Lipid-Protein Interactions and Motion in Membrane Bilayers -- Thyroid Hormones and Oxidative Phosphorylation -- Structure-Activity Relationships of Natural and Synthetic E-β-Methoxyacrylates of the Strobilurin and Oudemansin Series -- The Intracellular Mechanism of Insulin Action -- Unity and Diversity in Biological Redox Catalysis: Comparative Enzymology of Some Microbial Oxidoreductases Showing Variation in Cofactor Identity -- Ammonia-Forming, Dissimilatory Nitrite Reductases as a Homologous Group of Hexaheme C-Type Cytochromes in Metabolically Diverse Bacteria -- Halorhodopsin -- Control of Futile Transmembrane Potassium Cycling in Escherichia coli -- Bioenergetics of Protein Transport into Mitochondria: Role of ΔΨ and of Nucleoside Triphosphates -- Some Recent Functional and Structural Contributions to the Molecular Mechanism of Photosynthesis -- Salt Toxicity and Mineral Deficiency in Plants: Cytoplasmic Ion Homeostasis, a Necessity for Growth and Survival under Stress -- 4.2 Molecular Recognition and Communication -- 4.2 Molecular Recognition and Communication -- Dawn of Ca Research: Regulation of Muscle Contraction -- Comparative Aspects of the Mechanisms of Energy Transduction in Sarcoplasmic Reticulum between Rabbit and Frog Skeletal Muscle -- Caltrin: A Versatile Regulator of Calcium Transport in Spermatozoa -- Protein Kinase C, the Structural Heterogeneity and Differential Expression in Rat Brain -- Regulation of Erythrocyte Membrane Cytoskeletal Protein Interactions by Phosphorylation -- A Kinase Splitting Membranal Proteinase: Use in the Study of Receptors Involved in the Cellular Response to Hormones -- Fritz Lipmann, Phosphoproteins and Regulation of Aromatic Amino Acid Hydroxylase Activity -- The Regulation of Hepatic Phenylalanine Hydroxylase by Phosphorylation- Dephosphorylation -- Catabolite Inactivation and Adenylate Cyclase in Yeast -- Protein Modification by Tyrosine-Sulfation: Possible Functional Implications -- Proteoglycans and Connective Tissue Pathobiochemistry -- Acylation of Myelin Proteolipid Protein: A Link to the Past -- The Unusual Regulation of the Adenylyl cyclase of Amphibian Oocytes by Progesterone - A Review -- Sterol Synergism, a Tool for Studies on Sterol Function -- Chemical Modification of Benzodiazepine Receptors of Cortical P2 Membranes -- Dual Pathways for the Catabolism of γ- Hydroxybutyrate: Cytosolic and Mitochondrial Mechanisms -- 5. Evolution -- 5. Evolution -- Prebiotic Syntheses and the Mechanism of Early Chemical Evolution -- Prebiotic Roots of Informed Protein Synthesis: Nature of the Lipmann Connection -- A Case for an Additional RNA Base Pair in Early Evolution -- Inorganic Pyrophosphate in Cellular Energetics and Evolution -- Selforganization in Biosystems -- List of Contributors -- Acknowledgements -- Lipmann's Coworkers at Massachusetts General Hospital, Boston, and the Rockefeller University, New York -- Fritz Lipmann: Bibliography 1924-1985 -- Index