Lymphocyte Activation and Differentiation : : Fundamental and Clinical Aspects. Proceedings of the 18th International Leucocyte Culture Conference. La Grande Motte, France, June 19–24, 1987 / / ed. by J. Dornand, J. C. Mani.
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Table of Contents:
- Frontmatter
- PREFACE
- CONTENTS
- INTRODUCTION
- Fundamental and Clinical Aspects of Lymphocyte Activation and Differentiation
- PLENARY LECTURE
- Oncogenes and Multistep Carcinogenesis
- SYMPOSIA BIOCHEMICAL AND CELLULAR ASPECTS OF LYMPHOCYTE ACTIVATION
- Biochemical and Molecular Events Controlled by Lymphoid and Myeloid Growth Factors
- PGE2 Inhibition of Human T Lymphocytes Proliferation: Regulatory Effect of PGE2 on the Intra-Cellular Signaling Pathways
- Structure-Function Relationships for the Interleukin 2 Receptor
- Monovalent Cation Fluxes as Regulators of Critical Nuclear Events in Lymphocyte Activation: Mirror Image Processes in Differentiation and Proliferation
- Diacylglycerol, Calcium, cAMP and cGMP Mediate Qualitatively Distinct Protein Kinase C Translocation Events in Normal B Lymphocytes
- Phosphorylation of Prosolin and Leucocyte Growth Regulation
- DIFFERENTIATION OF T AND B LYMPHOCYTES
- Regulation of Human B Cell Function
- The Role of Lymphokines in the Immunoglobulin Class Switch
- Mouse and Human B Cell Activating Factors
- Molecular Cloning of the Murine T11 (CD2) cDNA
- Antigen Expression and Proliferative Activity during B and T Cell Development
- MOLECULAR BIOLOGY OF LEUCOCYTES (ANTIGENS, RECEPTORS, INTERLEUKINS)
- The Molecular Biology of the Multisubunit Interleukin-2 Receptor
- Expression and Rearrangement of T Cell Receptor Genes in Human Leukemic T Cell Lines
- The Human T-Cell Rearranging γ Genes (TRGγ)
- Immunoglobulin Gene Expression
- Structure and Expression of Mouse Fcy Receptor II (FcyRII)
- VIRUS-INDUCED LYMPHOCYTE DYSFUNCTIONS
- The Impact of the Presence of EBV on the Interaction of B Cell Lines with T Lymphocytes
- Induction of B Cell Activation Markers by Epstein-Barr Virus
- Production of Interleukin-1 (IL1) by EBV-Infected Cells
- DNA-Mediated Gene Transfer of Epstein-Barr Virus Receptor onto Murine Fibroblasts
- ACCESSORY CELL FUNCTIONS
- Modulation of IL1 Receptor Expression by IL1, Prostaglandins and Glucocorticoids
- Tumor Necrosis Factors: Modulation of Synthesis and Biological Activities
- Analysis of the Structure and Function of Immunectin
- Natural Effector Cells of the Intestinal Epithelium: Ontogeny, Function, and Regulation
- Analysis of Ia-Transfected Fibroblasts: Antibody and T Cell Recognition Sites Segregate with the 31 Domain of the E3 Polypeptide Chain
- WORKSHOPS WORKSHOP A. GROWTH AND DIFFERENTIATION FACTORS
- Inhibition by Cyclosporin A of the IL2 Dependent Autocrine Growth in a Human Tumor T Cell Line and Fate of IL2 Receptors after Endocytosis
- Interleukin B, a B Cell-Derived Lymphokine
- Induction and Enhancement of Lymphokine Gene Expression in Human T Cell Clones Transfected with HTLV-I pX cDNA
- Evidence for a Human B Cell Activating Factor Acting on Resting B Lymphocytes
- Splicing Intermediates of the IL-2 Receptor (p55 Subunit)
- The Role of Plasminogen Activator in Regulating T Cell Proliferation and Interferon Production
- Membrane and Soluble IL2-R Produced by Human T Cell Clones: A Comparative Study
- Phenotype and Cytokines Production by Human Myeloma Cell Lines
- B + Null Cell-Derived Prothymocyte Differentiating Activity (PTDA): Biological Properties and Physicochemical Characterization
- TDM-Activated Macrophages Produce a Cytostatic Factor Distinct from TNFα, IFNα,β, and IL-1
- Characterization of a Factor Produced by Human Alloreactive T Cell Clones
- WORKSHOP B. MECHANISMS OF AUTOIMMUNITY
- Effector Mechanisms of Autoimmune Diseases
- T Cell Response to Myelin Basic Protein in Healthy Subjects and Multiple Sclerosis Patients
- Active T Cell Regulation of Autoimmune Responses in Autoimmune and "Nonautoimmune" Spleen Cell Populations
- Interleukin-2 Receptor Targeted Immunotherapy of Autoimmune Diseases: Treatment Strategies for Type I Diabetes
- Protection of Non-Obese Diabetic (NOD) Mice from Insulitis by Neonatal Injection of F1 Spleen Cells
- WORKSHOP C. ONCOGENES AND LEUCOCYTE TRANSFORMATION
- Complex Transcriptional Regulation of Nuclear Proto Oncogenes: Existence of a Block to Elongation in C-Myc and C-Fos Genes
- Determinants of C-Fos and C-Myc mRNAs Instability
- Cloning and Functional Analysis of the Human C-fms Gene
- Effects of Proliferative (Interleukin, Colony Stimulating Factors) and Antiproliferative (Cyclic AMP, Interferon) Signals on Gene Expression in Myeloid and Lymphoid Cell Lines
- The Progession to Tumourigenes is Following Transformation of Murine Myelomonocytic Cell by V-Myc
- HTLV-I Infection of a Human Antigen Specific Proliferating/Cytotoxic T Cell Clone Results in a Loss of Cytotoxicity but does not Affect the T Cell Receptor
- WORKSHOP D. EXPERIMENTAL MODELS OF IMMUNOMODULATION
- Roles of Monokines in the Nonspecific Host Defence Stimulated by Exogenous Agents
- Enhancement of the Immune Response Using a Synthetic B-Lymphocyte Mitogen Covalently Linked to Antigens
- Effects of in vivo Treatment of Mice with Anti-Murine T3 Antibody: Suppression of Transplantation Responses
- Gamma-Interferon Protects Listeria-Susceptible BALB/c Mice from Lethal Listeriosis without Affecting the Development of Protective Immunity
- Effect of a Lipophilic Muramylitri peptide on Gamma-Interferon Induced Major Histocompatibility Antigen (MHC) and Leu-M3 Antigen Changes in Human Monocytes
- Effect of Cyclosporin A (CsA) on the Induction of Memory T Lymphocytes
- Modulation by Cyclosporin A (CsA) of the Immune System of Mice Infected with Lymphocytic Choriomeningitis Virus (LCMV)
- Modulation of Lymphocyte Activation in vitro by a Soluble Placental Factor
- The Role of Interleukins and the Interleukin-2 Receptor in the Pathogenesis of Murine Cutaneous Leishmaniasis
- In vitro Studies of Synthetic Glycolipids: A New Class of Compounds with Immunomodulating Activity
- Immunotoxicity Studies of PCB (Aroclor 1254) in the Adult Rhesus (Macaca mulatta) Monkey
- Human Cytomegalovirus Induces Alterations in Mixed Lymphocyte Reactions
- WORKSHOP E. IMMUNODEFICIENCIES
- Immunological Aspects of AIDS and HIV Infection
- Studies Regarding the Interaction of the T4 (CD4) Molecule with the Envelope Protein gp120 of the Human Immunodeficiency Virus (HIV)
- Low Level Re-Expression of the Silent MHC Class-II Genes in the Lymphoblasts from Patients with the HLA-Class II Deficient SCID
- Adenylate Cyclase and 5'Nucleotidase Activities of Peripheral Blood Mononuclear Cells is Psoriasis
- WORKSHOP F. NATURAL KILLER CELLS
- Natural Killer Cells
- Characterization and Population Kinetics of Liver-Associàted Large Granular Lymphocytes (Natural Killer Cells)
- Modulation of Lymphonkine Activated Killer Activity of Lymphocytes Isolated from Human Peripheral Blood and Bone Marrow by Recombinant IL4
- Inhibition of Human Natural Killer Cells by Resistant Target Cells
- Changes in Gene Expression Associated with Activation or Inhibition of Natural Killer Function
- Fibronectin Expression by Endogenous and Activated NK Cells
- Cytolytic Potential of CD3+4-8- T Cells with Differently Organized T Cell Receptor Y Chains
- WORKSHOP G, DIFFERENTIATION AND ACTIVATION OF T LYMPHOCYTES
- CD1a Molecules Form Intermolecular Complexes with HLA Class I Molecules or Other CD1 Molecules on Normal Human Thymus Cells
- The CD2 Pathway of Activation. Epitope Requirements, Linkage to Other Surface Molecules and Early Biochemical Events
- A T-Cell Surface Molecule Different from CD2 is Involved in Spontaneous Rosette Formation with Erythrocytes
- A Dual Function of the T4 Molecule in the Cytolytic Activity of Human T Cell Clones
- Role of Antigen-Specific T Cell Receptor and Associated Proteins in the Activation of a Cytolytic T Cell Clone Analysed by Protein Phosphorylation and by T Cell Receptor Negative Variants
- Y-Chain T Cell Receptors on Denoritic Epidermal Cells
- Stimulation of T Cells via LY-6C: A Phssphatidylinositol-Anchored Cell Surface Molecule which Generates Intracellular Calcium Mobilization upon Cross-Linking
- New Subgroups in the Human T Cell Rearranging VΓ Gene Locus
- Genomic Organisation of the Constant Regions of the Human T-Cell Rearranging Gene Γ
- Second Signals for T Cell Mitogenesis Provided by a MAbs CD45 (T200) and CD5 (T1)
- WORKSHOP H.
- DIFFERENTIATION AND ACTIVATION OF B LYMPHOCYTES
- Immunobiology of B Lymphocytes
- Regulation of B Lymphocyte Responsiveness by Multiple Cytokines
- Influence of IL4 on the Induction of Immunoglobulin Secretion by BCAF-Containing Supernatant
- Early B Cells Immortalized by Epstein-Barr Virus (EBV) - A Phenotypic Study
- The Human B Cell Repertoire: Multispecificity as a Major Characteristic of Antibodies Secreted by Human EBV-Transformable Cord Blood B Cells
- Analysis of Excessive B Cell Growth in Lymph Nodes of L. major Infected Mice: The Effect of L. major Specific T-Cell Clones
- Antibody Response in vitro of Human Peripheral Blood Lymphocytes: Application of a Limiting Dilution Method
- Frequency Analysis of Functional Immunoglobulin CE Gene Expression in LPS-Reactive Murine B Cells
- Changes in Gene Expression in Differentiating B Lymphocytes
- Regulation of Lipopolysaccharide (LPS)-Induced B Cell Differentiation by Ly-5 and Uyb-2 Molecules
- WORKSHOP I. LIPIDIC MEDIATORS OF THE IMMUNE RESPONSE
- Phospholipid-Derived Mediators and the Immune Response
- Anti-Oxidants and IL2 Synthesis
- Role of Lipoxygenase Pathway Products in IL2 Synthesis
- Platelet Activating Factor (PAF) Induces Human Suppressor Cell Activity
- PAF-Acether Induces an Enhanced Release of Interleukin-1 (IL-1) from Human Monocytes
- Down-Regulation of CD2 and CD3 Antigen Expression by PAF-Acether
- WORKSHOP J. NEURAL MODULATION OF IMMUNITY
- Neuroendocrine Modulation of Immunity
- Cyclic AMP Response to Dopamine in the Human Monocyte-Like Cell Line U-937
- ß-Endorphin Inhibits Thy-1 Antigen Expression on Murine Thymocytes and Antagonizes Thymosin Fraction V Action
- WORKSHOP K. BIOCHEMISTRY OF LEUCOCYTE STIMULATION AND EFFECTOR MECHANISMS
- Genes Preferentially Expressed in Cytolytic T Cells
- Signal Transduction in Lymphocyte Activation
- IL-2 Mediated Induction of Lytic Granules, Perforin, and BLT-Esterase in Potent, Granule-Free Cytolytic T Lymphocytes Indicates an Alternative Function of Lytic Granules
- Extracel1ular ATP Initiates the Proliferative Response of PMA-Activated Medullary Thymocytes by Increasing their Cytosolic Free Calcium Concentration
- Evidence for a Kinase Cascade Stimulated by Interleukin 2 in Cytotoxic T Cell Clones
- The Regulation of Cytoskeletal Protein Gene Expression in Lymphocytes
- Protein Phosphorylation During T Cell Activation
- Clues to Mechanisms of Activation for Killing from the Observations of Changes in Intracellular (Ca++) in Individual Cytolytic T Cells and Targets
- Induction of Activation Signals in Human T Lymphocytes
- Both Lyt2+ and L3T4+ Cell Subsets Secrete the Serine Esterase Granzyme A in Response to a Specific Antigenic Stimulus
- WORKSHOP L. ACCESSORY CELLS-LYMPHOCYTE INTERACTIONS
- Accessory Cells-Lymphocyte Interactions
- A Role for HLA-Class I Molecules from Accessory Cells in T-Cell Activation
- Adhesion Molecules of Monocytes
- Cellular and Molecular Basis of Self-Induced Proliferation of T Lymphocytes (SIPofT)
- Human T Cell Activation: Participation of T Cell Differentiation Antigen Cluster 2 (CD2) in the Generation and/or Transduction of Accessory Cell Signals
- WORKSHOP PI. IDIOTYPIC REGULATION
- The Influence of Vk Gene Polymorphism on the Induction of Silent Idiotypes in the Arsonate System
- Allogeneic Manipulation of the "GAT" Idiotypic Cascade does not Influence the VH Gene Usage
- Specific Suppression of the Primary Antibody Response with Immune Complexes Formed in Antibody Excess Depends on the Idiotype and the Isotype of the Antibody Forming the Complex
- The HLA-Restricted Presentation of Idiotype to Human Anti-Idiotypic T Cell Clones does not Require Processing by Antigen Presenting Cells
- Idiotypic Predominance Alteration in Anti-Arsonate Response by Priming with Anti-Idiotypic Antibodies
- Anti-Idiotype Induction of Humoral Immunity in Cattle
- Anti MHC-Receptor Cytotoxic T Lymphocytes: Their Role in the Specific Resistance to Graft-Versus-Host Reaction
- Altered Anti-Idiotype Response to a(1-3)Dextran-Associated Idiotypes in Mice Bearing an X-Linked Immune Defect
- WORKSHOP N. COMPLEMENT RECEPTORS
- Human CD3 Complement Receptors
- Influence of Antigen-Bound Complement Components C3b and C4b in Activation of Human T-Cell Clones
- Human C3 and C3dg Stimulate Proliferation of a Pre-B Lymphoblastoid Cell Line via CR2 Complement Receptor
- Activation of B Lymphocytes by Zymosan-Bound C3 Fragments
- Contribution of C3 Fragments to Lymphocyte Mediated Lysis of CR2 Carrying Cells
- "In vivo" and "in vitro" Modulation of CR1 (C3b Receptor) Expression by its Ligand C3b
- WORKSHOP O. MAJOR HISTOCOMPATIBILITY COMPLEX
- MHC in Leucocyte Biology
- HLA Class I α1, α2, and ß2-Microglobulin Domain Interactions
- Diversity and Function of Human Class II MHC Antigens
- DRα-DQß Mismatched Isotype Pairing Occurs in EBV Transformed B Cell Lines
- Distinct Epitopes for Kd-Restricted Cytolytic T Cells Specific for HLA-CW3 or HLA-A24 Map to the same Region of HLA
- Resistance or Susceptibility of Human Target Cells to NK Lysis: Correlation with the Surface Expression of HLA Class I Molecules and Induction of Susceptibility by Monoclonal Anti Class I Antibodies
- WORKSHOP P (SANOFI). CLINICAL APPLICATIONS OF ANTILEUCOCYTE MONOCLONAL ANTIBODIES
- Anti-Leucocyte Monoclonal Antibodies: From Laboratory Reagents to Therapeutic Agents
- Treatment of Donor Bone Marrow with FabT101 Ricin A-Chain Immunotoxin for the Prevention of Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation
- Monoclonal Antibodies for Bone Marrow Purging before Transplantation: A Brief Review
- Comparative Efficiency of an Immunomagnetic Purging Procedure and a Rabbit Complement Lysis to Eliminate BL Cells from the Bone Marrow
- In vivo Antigenic Modulation of CD5+ Cells in Renal Transplanted Patients Receiving Anti-CD5 Antibody Infusions
- In vivo Therapy by CD8 Monoclonal Antibody for Delays to Hematological Recovery after Autologous Bone Marrow Transplantation
- Autologous Bone Marrow Transplantation for Acute Lymphoblastic Leukemia in Remission. In vitro Purging of Inoculum with Monoclonal Antibodies and Complement
- Immunosuppression by Murine Monoclonal Antibodies: The Rhesus Monkey Used for Preclinical Testing
- Therapeutic Applications of Monoclonal Antibodies for Lymphoma and Leukemia
- BMA 031 - The TCR Specific Monoclonal Antibody for Clinical Applications
- Immunoassays for the Monitoring of Kidney Graft's Transplanted Patients under 33B3.1 MOAB Therapy
- Prospective Randomized Studies of T Cell Depletion in HLA Matched Bone Marrow Transplantation (BMT) for Leukemia: 2 Studies of the GEGMO in 92 Patients
- A Monoclonal Anti Interleukin 2 Receptor Prevents Human Kidney Graft Rejection
- Clinical Pharmacology of 0KT3
- Introduction to the Clinical Use of Monoclonal Antibodies as Immunosuppressive Agents
- General Considerations on the Quality Control of Monoclonal Antibodies before Therapeutic Use in Man
- Immunotoxins with Therapeutic Use in Man
- AUTHOR INDEX
- SUBJECT INDEX
- Backmatter
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