Lymphocyte Activation and Differentiation : : Fundamental and Clinical Aspects. Proceedings of the 18th International Leucocyte Culture Conference. La Grande Motte, France, June 19–24, 1987 / / ed. by J. Dornand, J. C. Mani.

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• MitwirkendeR: Abehsira-Amar, O.,; Akahoshi, T.,; Alsinet, E.,; Aman, P.,; Ambrus, J. L.,; Amiot, M.,; Andary, M.,; Anderson, V.,; Ang, S. L.,; Arai, K. I.,; Armand, J.,; Arnold, D. L.,; Arulanandan, A.,; Arvieux, J.,; Ashida, T.,; Aubrit, F.,; Bach, J. F.,; Bach, M. A.,; Baehr, R. V.,; Bagnasco, M.,; Ballieux, R. E.,; Bataille, R.,; Beatty, P. G.,; Bekkhoucha, F.,; Benner, R.,; Bensimon, C.,; Benveniste, J.,; Berke, G.,; Bernard, A.,; Bertoglio, J.,; Besedovsky, H.,; Bessler, W. G.,; Billaud, M.,; Birg, F.,; Birnbaum, D.,; Biron, P.,; Bishop, J. M.,; Blaise, D.,; Blanc, M.,; Blanchard, D.,; Blanchard, J. M.,; Blattner, F.,; Bluestone, J. A.,; Blume, K. G.,; Blythman, H. E.,; Boasson, M.,; Boeffard, F.,; Bolhuis, R. L. H.,; Boltz, R. C.,; Bonadonna, L.,; Bonnafous, J. C.,; Bonnerot, C.,; Bonneville, M.,; Bonnieu, A.,; Borche, L.,; Bordigoni, A.,; Borst, J.,; Bouloux, C.,; Boumsell, L.,; Bourrie, B.,; Bouvrette, L.,; Bouwens, L.,; Boyer, C.,; Brait, M.,; Braquet, P.,; Braverman, R.,; Brochier, J.,; Brown, E.,; Brunet, J. F.,; Bruskin, A.,; Bryce, F.,; Buferne, M.,; Bunschoten, H.,; Burroughs, D.,; Busson, P.,; Böltz, T.,; Bösing-Schneider, R.,; Cahn, J. Y.,; Calender, A.,; Calkins, C. E.,; Cambier, J. C.,; Campana, D.,; Cantaloube, J. F.,; Cantarovich, D.,; Cantor, H.,; Capra, J. D.,; Carayon, P.,; Carosella, E.,; Casellas, P.,; Caulfield, M. J.,; Cerdan, C.,; Cerottini, J. C.,; Chantler, P.,; Charron, D.,; Chastagner, P.,; Chatenoud, L.,; Chen, Z. Z.,; Chocquet, A.,; Chouaib, S.,; Claassen, I .,; Clark, E. A.,; Clayton, L. K.,; Clot, J.,; Cochran, S. A.,; Coligan, J. E.,; Colomb, M. G.,; Combaret, V.,; Cook, G. P.,; Cooper, H. L.,; Corbet, S.,; Cordier, G.,; Corley, R. B.,; Corradin, G.,; Courcoul, M.,; Coustan-Smith, E.,; Coutinho, A.,; Crastes De Paulet, A.,; Daeron, M.,; Dastot, H.,; Dausset, J.,; Dautry-Varsat, A.,; De Vries, J. E.,; De Waal Malefijt, R.,; Degos, L.,; Del Guercio, P.,; Del Rey, A.,; Delage, M.,; Denizot, F.,; Derocq, J. M.,; Deryckx, S.,; Deschaux, P. A.,; Diamantstein, T.,; Dierich, M. P.,; Dimanche, M. T.,; Diu, A.,; Dornand, J.,; Dreyfus, F.,; Du, R.-P.,; Dubigeon, P.,; Dubreuil, P.,; Due Dodon, M.,; Dukor, P.,; Dulioust, A.,; Dumont, F. J.,; Dunger, A.,; Dupperay, C.,; Duprez, V.,; Durfee, T.,; Dussossoy, D.,; D’Orazi, G.,; El Moatassim, C.,; Emilie, D.,; Evans, S. W.,; Even, J.,; Fahey, D.,; Farrar, W. L.,; Fauci, A. S.,; Favrot, M. C.,; Favrot, M.,; Fehlmann, M.,; Ferrer, M.,; Ferris, D. K.,; Fevrier, M.,; Figdor, C. G.,; Fischer, E.,; Flesch, M.,; Foon, K. A.,; Forman, S. J.,; Foroni, L.,; Forster, A.,; Fort, P.,; Fougereau, M.,; Fradelizi, D.,; Frati, L.,; Freeman, G.,; Freixas, M.,; Fridman, W. H.,; Froussard, P.,; Frugoni, P.,; Gahmberg, C. G.,; Galli, S. J.,; Gascan, H.,; Gaspard, M. H.,; Gaya, A.,; Gazzolo, L.,; Gerber, M.,; Gergely, J.,; Ghanem, N.,; Giacomini, E.,; Gillet, A.,; Gismondi, A.,; Gladstone, P.,; Gluckman, E.,; Gmelig-Meyling, F.,; Godard, A.,; Goeddel, D. V.,; Goldman, C.,; Goldsby, R. A.,; Goldstein, H.,; Golstein, P.,; Gombert, J.,; Goodwin, J. S.,; Goube De Laforest, P.,; Gougeon, M. L.,; Gregory, C. D.,; Griseelli, C.,; Gros, O.,; Gros, P.,; Guilhou, J. J.,; Guillon, J. -C.,; Guimezanes, A.,; Gunther, C.,; Guyot, A.,; Guyotat, D.,; Hafler, D.,; Hahn, H. J.,; Hakem, R.,; Halbwachs-Mecarelli, L.,; Halle-Pannenko, O.,; Harel-Bellan, A.,; Harper, K.,; Hashim, G.,; Hatzfeld, A.,; Hatzfeld, J.,; Hayward, A. R.,; Hayward, S.,; Heiskala, M. K.,; Hemar, A.,; Herve, P.,; Hill, J.,; Hirn, M.,; Hirsch, R.,; Hogarth, P. M.,; Hoor, G. Ten,; Hoover, R.,; Hourmant, M.,; Howell, M. D.,; Huch, S.,; Huet, S.,; Ifrah, N.,; Jacobson, S.,; Jacques, Y.,; Jankovic, D. L.,; Jankovic, D.,; Janossy, G.,; Jansen, F. K.,; Jansen, F.,; Jeanteur, P.,; Jelinek, D. F.,; Jonker, M.,; Jordan, B. R.,; Jordan, B.,; Jourdan, M.,; Jung, G.,; Kahn-Perles, B.,; Kai, C.,; Kaldy, P.,; Kaminski, M. S.,; Kaplan, J. G.,; Katagiri, M.,; Kawabata, I.,; Kazatchkine, M. D.,; Kiderlen, A. F.,; Kimura, N.,; King, L. B.,; Kirschgens, C.,; Klein, B.,; Klein, E.,; Klein, G.,; Klein, J. R.,; Klimetzek, V.,; Kloting, I.,; Koning, F.,; Kornbluth, J.,; Kosmatopoulos, K.,; Kouassi, E.,; Kracht, M.,; Krebs, B.,; Kroon, A.,; Kurrle, R.,; Kuttler, B.,; Körner, M.,; Landmann, R.,; Langlet, C.,; Latour, M.,; Laurent, G.,; Laurent, J. C.,; Layet, C.,; Le Mauff, B.,; Leahy, M.,; Lebleu, B.,; Leblond, V.,; Lecron, J. C.,; Lefranc, M. -P.,; Lefranc, M. P.,; Lemaire, G.,; Lemonnier, F. A.,; Lenoir, G.,; Leo, O.,; Lepoivre, M.,; Levesque, J. P.,; Lew, A. M.,; Li, Y. S.,; Linssen, P. C. L. M.,; Lipsky, P. E.,; Lisowska-Grospierre, A.,; Littmann, D.,; Lockhoff, O.,; Logtenberg, T.,; Lohmann-Matthes, M. L.,; Lohoff, M.,; Long, E. O.,; Longacre, S.,; Longhi, B.,; Loo, J. C. K.,; Lotteau, V.,; Luzzati, A. L.,; MacDonald, H. R.,; Mach, B.,; Mahe, Y.,; Maiissen, B.,; Mak, T. W.,; Maloy, W. L.,; Mani, J. C.,; Mannoni, P.,; Maraninchi, D.,; Marchiol, C.,; Martorell, J.,; Marvel, J.,; Maryanski, J. L.,; Mason, J. O.,; Matsushima, K.,; Mawas, C.,; McCairns, E.,; McFarland, H. F.,; McFarland, P.,; McMillan, M.,; Mechti, N.,; Metzger, J.,; Michallet, M.,; Michel, F.,; Miller, R. D.,; Milstein, C.,; Mir, A.,; Miyatake, S.,; Modesti, A.,; Moore, J. S.,; Moreau, J. F.,; Moreau, J. L.,; Morrone, S.,; Mossalayi, M. D.,; Mostowski, H.,; Motta, I.,; Murthi, V. K.,; Nabholz, M.,; Nakagawa, N.,; Nakagawa, T.,; Nashan, B.,; Neuberger, M. S.,; Noir, A.,; Novogrodsky, A.,; Novotny, J.,; Olive, D.,; Oppenheim, J. J.,; Orbach-Arbouys, S.,; Orfanos, G.,; Osterhaus, A.,; O’Brien, R. L.,; O’Grady, L.,; Paessens, A.,; Pala, P.,; Palfree, R. R.,; Parant, M.,; Patarca, R.,; Patarroyo, M.,; Paul, W. E.,; Pebusque, M. J.,; Perarnau, B.,; Peters, M.,; Petit, J. F.,; Pettersson, S.,; Peyron, J. F.,; Peyronnet, P.,; Philip, I.,; Philip, T.,; Piccoli, M.,; Pico, J. L.,; Piechaczyk, M.,; Pierres, A.,; Pierres, M.,; Pignol, B.,; Planche, J.,; Plouvier, E.,; Poenie, M.,; Poncelet, P.,; Pontarotti, P.,; Porteu, F.,; Pouliot, C.,; Prasad, K. V. S.,; Prieto, J.,; Punturieri, A.,; Quastel, M. R.,; Quillet, A.,; Rabbits, T. H.,; Rabbits, T.,; Rabbitts, T. H.,; Racadot, E.,; Ramos, O.,; Raynal, B.,; Rebai, N.,; Rech, J.,; Reiffers, J.,; Reik, W.,; Reinherz, E. L.,; Resch, K.,; Revillard, J. P.,; Richer, G.,; Rickinson, A. B.,; Rio, B.,; Robb, R. J.,; Rojo, I.,; Rola-Pleszczynski, M.,; Rosen, D.,; Rosen-Bronson, S.,; Roth, C.,; Rothermel, A. L.,; Rouabhia, M.,; Rouet, R.,; Rowe, M.,; Rowe, P. B.,; Röllinghoff, M.,; Sachs, D. H.,; Sahai, B. M.,; Sahai, B.,; Sakata, H.,; Salem, P.,; Santoni, A.,; Sarmay, G.,; Saron, M. -F.,; Sauer, D.,; Savelkoul, H. F. J.,; Sayre, P. H.,; Scarpa, S.,; Schiff, C.,; Schild, G. C.,; Schlumberger, H. D.,; Schmitt-Verhulst, A. M.,; Schneider, P.,; Schwartz, J.,; Schwartz, R.,; Scott-Agara, D.,; Segal, S.,; Seidman, J. G.,; Seiinka, H. C.,; Seiki, M.,; Seiler, F. R.,; Sekaly, R. P.,; Sekkat, C.,; Seligmann, M.,; Severini, A.,; Sharma, S.,; Sharpe, M. J.,; Shevach, E. M.,; Shidani, B.,; Simpson, E.,; Singh, R.,; Sire, J.,; Sitia, R.,; Skibin, A.,; Snapper, C. M.,; Sodoyer, R.,; Solbach, W.,; Soulillou, J. P.,; Spits, H.,; Spooner, C. A.,; Stapleton, P.,; Stehelin, D.,; Stenzel, K. H.,; Stingl, G.,; Stlinkel, K. G.,; Strachan, T.,; Streck, H.,; Streissle, G.,; Suarez, H. G.,; Subramaniam, A.,; Surani, M. A.,; Suthanthiran, M.,; Sutton, L.,; Symonds, G.,; Szamel, M.,; Szigeti, R.,; Takayama, Y.,; Tanzer, J.,; Tassignon, J.,; Tate, G.,; Tayler, R.,; Tenner, A.,; Termeulen, J.,; Testi, R.,; Teyton, L.,; Theze, J.,; Thomas, Y.,; Thorpe, R.,; Tosato, G.,; Toubert, A.,; Tournier-Lasserve, E.,; Traeger, J.,; Truffa-Bachi, P.,; Tryphonas, H.,; Tsien, R. Y.,; Tsudo, M.,; Tursz, T.,; Uckun, F.,; Urbain, J.,; Uytdehaag, F.,; Van De Griend, R. J.,; Van der Linde-Preesman, A. A.,; Vandest, P.,; Varin, N.,; Velotti, F.,; Vernant, J. P.,; Vidal, H.,; Vilella, R.,; Vives, J.,; Vivier, E.,; Voisin, G. A.,; Volk, H. D.,; Wakasugi, H.,; Waldmann, T. A.,; Wesp, M.,; Weston, K.,; Wierenga, E.,; Wiesmüller, K. H.,; Williams, G. T.,; Wisse, E.,; Witort, E.,; Witzel, N.,; Wong, G. H. W.,; Wonigeit, K.,; Wright, C. L.,; Yakura, H.,; Yefenov, E.,; Yokota, T.,; Yokoyama, W. M.,; Yoshida, M.,; Young, K. R.,; Young, L. S.,; Yssel, H.,; Zaia, J. A.,; Zawidzka, Z. Z.,; Zerban, R.,; Zolnay, S.,; Zucker, J. M.,
• HerausgeberIn: Dornand, J.,; Mani, J. C.,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2019]; ©1988
• Year of Publication: 2019
• Edition: Reprint 2019
• Language: English
• Physical Description: 1 online resource (XXI, 960 p.) :; Num. figs.

Table of Contents

Frontmatter -- PREFACE -- CONTENTS -- INTRODUCTION -- Fundamental and Clinical Aspects of Lymphocyte Activation and Differentiation -- PLENARY LECTURE -- Oncogenes and Multistep Carcinogenesis -- SYMPOSIA BIOCHEMICAL AND CELLULAR ASPECTS OF LYMPHOCYTE ACTIVATION -- Biochemical and Molecular Events Controlled by Lymphoid and Myeloid Growth Factors -- PGE2 Inhibition of Human T Lymphocytes Proliferation: Regulatory Effect of PGE2 on the Intra-Cellular Signaling Pathways -- Structure-Function Relationships for the Interleukin 2 Receptor -- Monovalent Cation Fluxes as Regulators of Critical Nuclear Events in Lymphocyte Activation: Mirror Image Processes in Differentiation and Proliferation -- Diacylglycerol, Calcium, cAMP and cGMP Mediate Qualitatively Distinct Protein Kinase C Translocation Events in Normal B Lymphocytes -- Phosphorylation of Prosolin and Leucocyte Growth Regulation -- DIFFERENTIATION OF T AND B LYMPHOCYTES -- Regulation of Human B Cell Function -- The Role of Lymphokines in the Immunoglobulin Class Switch -- Mouse and Human B Cell Activating Factors -- Molecular Cloning of the Murine T11 (CD2) cDNA -- Antigen Expression and Proliferative Activity during B and T Cell Development -- MOLECULAR BIOLOGY OF LEUCOCYTES (ANTIGENS, RECEPTORS, INTERLEUKINS) -- The Molecular Biology of the Multisubunit Interleukin-2 Receptor -- Expression and Rearrangement of T Cell Receptor Genes in Human Leukemic T Cell Lines -- The Human T-Cell Rearranging γ Genes (TRGγ) -- Immunoglobulin Gene Expression -- Structure and Expression of Mouse Fcy Receptor II (FcyRII) -- VIRUS-INDUCED LYMPHOCYTE DYSFUNCTIONS -- The Impact of the Presence of EBV on the Interaction of B Cell Lines with T Lymphocytes -- Induction of B Cell Activation Markers by Epstein-Barr Virus -- Production of Interleukin-1 (IL1) by EBV-Infected Cells -- DNA-Mediated Gene Transfer of Epstein-Barr Virus Receptor onto Murine Fibroblasts -- ACCESSORY CELL FUNCTIONS -- Modulation of IL1 Receptor Expression by IL1, Prostaglandins and Glucocorticoids -- Tumor Necrosis Factors: Modulation of Synthesis and Biological Activities -- Analysis of the Structure and Function of Immunectin -- Natural Effector Cells of the Intestinal Epithelium: Ontogeny, Function, and Regulation -- Analysis of Ia-Transfected Fibroblasts: Antibody and T Cell Recognition Sites Segregate with the 31 Domain of the E3 Polypeptide Chain -- WORKSHOPS WORKSHOP A. GROWTH AND DIFFERENTIATION FACTORS -- Inhibition by Cyclosporin A of the IL2 Dependent Autocrine Growth in a Human Tumor T Cell Line and Fate of IL2 Receptors after Endocytosis -- Interleukin B, a B Cell-Derived Lymphokine -- Induction and Enhancement of Lymphokine Gene Expression in Human T Cell Clones Transfected with HTLV-I pX cDNA -- Evidence for a Human B Cell Activating Factor Acting on Resting B Lymphocytes -- Splicing Intermediates of the IL-2 Receptor (p55 Subunit) -- The Role of Plasminogen Activator in Regulating T Cell Proliferation and Interferon Production -- Membrane and Soluble IL2-R Produced by Human T Cell Clones: A Comparative Study -- Phenotype and Cytokines Production by Human Myeloma Cell Lines -- B + Null Cell-Derived Prothymocyte Differentiating Activity (PTDA): Biological Properties and Physicochemical Characterization -- TDM-Activated Macrophages Produce a Cytostatic Factor Distinct from TNFα, IFNα,β, and IL-1 -- Characterization of a Factor Produced by Human Alloreactive T Cell Clones -- WORKSHOP B. MECHANISMS OF AUTOIMMUNITY -- Effector Mechanisms of Autoimmune Diseases -- T Cell Response to Myelin Basic Protein in Healthy Subjects and Multiple Sclerosis Patients -- Active T Cell Regulation of Autoimmune Responses in Autoimmune and "Nonautoimmune" Spleen Cell Populations -- Interleukin-2 Receptor Targeted Immunotherapy of Autoimmune Diseases: Treatment Strategies for Type I Diabetes -- Protection of Non-Obese Diabetic (NOD) Mice from Insulitis by Neonatal Injection of F1 Spleen Cells -- WORKSHOP C. ONCOGENES AND LEUCOCYTE TRANSFORMATION -- Complex Transcriptional Regulation of Nuclear Proto Oncogenes: Existence of a Block to Elongation in C-Myc and C-Fos Genes -- Determinants of C-Fos and C-Myc mRNAs Instability -- Cloning and Functional Analysis of the Human C-fms Gene -- Effects of Proliferative (Interleukin, Colony Stimulating Factors) and Antiproliferative (Cyclic AMP, Interferon) Signals on Gene Expression in Myeloid and Lymphoid Cell Lines -- The Progession to Tumourigenes is Following Transformation of Murine Myelomonocytic Cell by V-Myc -- HTLV-I Infection of a Human Antigen Specific Proliferating/Cytotoxic T Cell Clone Results in a Loss of Cytotoxicity but does not Affect the T Cell Receptor -- WORKSHOP D. EXPERIMENTAL MODELS OF IMMUNOMODULATION -- Roles of Monokines in the Nonspecific Host Defence Stimulated by Exogenous Agents -- Enhancement of the Immune Response Using a Synthetic B-Lymphocyte Mitogen Covalently Linked to Antigens -- Effects of in vivo Treatment of Mice with Anti-Murine T3 Antibody: Suppression of Transplantation Responses -- Gamma-Interferon Protects Listeria-Susceptible BALB/c Mice from Lethal Listeriosis without Affecting the Development of Protective Immunity -- Effect of a Lipophilic Muramylitri peptide on Gamma-Interferon Induced Major Histocompatibility Antigen (MHC) and Leu-M3 Antigen Changes in Human Monocytes -- Effect of Cyclosporin A (CsA) on the Induction of Memory T Lymphocytes -- Modulation by Cyclosporin A (CsA) of the Immune System of Mice Infected with Lymphocytic Choriomeningitis Virus (LCMV) -- Modulation of Lymphocyte Activation in vitro by a Soluble Placental Factor -- The Role of Interleukins and the Interleukin-2 Receptor in the Pathogenesis of Murine Cutaneous Leishmaniasis -- In vitro Studies of Synthetic Glycolipids: A New Class of Compounds with Immunomodulating Activity -- Immunotoxicity Studies of PCB (Aroclor 1254) in the Adult Rhesus (Macaca mulatta) Monkey -- Human Cytomegalovirus Induces Alterations in Mixed Lymphocyte Reactions -- WORKSHOP E. IMMUNODEFICIENCIES -- Immunological Aspects of AIDS and HIV Infection -- Studies Regarding the Interaction of the T4 (CD4) Molecule with the Envelope Protein gp120 of the Human Immunodeficiency Virus (HIV) -- Low Level Re-Expression of the Silent MHC Class-II Genes in the Lymphoblasts from Patients with the HLA-Class II Deficient SCID -- Adenylate Cyclase and 5'Nucleotidase Activities of Peripheral Blood Mononuclear Cells is Psoriasis -- WORKSHOP F. NATURAL KILLER CELLS -- Natural Killer Cells -- Characterization and Population Kinetics of Liver-Associàted Large Granular Lymphocytes (Natural Killer Cells) -- Modulation of Lymphonkine Activated Killer Activity of Lymphocytes Isolated from Human Peripheral Blood and Bone Marrow by Recombinant IL4 -- Inhibition of Human Natural Killer Cells by Resistant Target Cells -- Changes in Gene Expression Associated with Activation or Inhibition of Natural Killer Function -- Fibronectin Expression by Endogenous and Activated NK Cells -- Cytolytic Potential of CD3+4-8- T Cells with Differently Organized T Cell Receptor Y Chains -- WORKSHOP G, DIFFERENTIATION AND ACTIVATION OF T LYMPHOCYTES -- CD1a Molecules Form Intermolecular Complexes with HLA Class I Molecules or Other CD1 Molecules on Normal Human Thymus Cells -- The CD2 Pathway of Activation. Epitope Requirements, Linkage to Other Surface Molecules and Early Biochemical Events -- A T-Cell Surface Molecule Different from CD2 is Involved in Spontaneous Rosette Formation with Erythrocytes -- A Dual Function of the T4 Molecule in the Cytolytic Activity of Human T Cell Clones -- Role of Antigen-Specific T Cell Receptor and Associated Proteins in the Activation of a Cytolytic T Cell Clone Analysed by Protein Phosphorylation and by T Cell Receptor Negative Variants -- Y-Chain T Cell Receptors on Denoritic Epidermal Cells -- Stimulation of T Cells via LY-6C: A Phssphatidylinositol-Anchored Cell Surface Molecule which Generates Intracellular Calcium Mobilization upon Cross-Linking -- New Subgroups in the Human T Cell Rearranging VΓ Gene Locus -- Genomic Organisation of the Constant Regions of the Human T-Cell Rearranging Gene Γ -- Second Signals for T Cell Mitogenesis Provided by a MAbs CD45 (T200) and CD5 (T1) -- WORKSHOP H.

DIFFERENTIATION AND ACTIVATION OF B LYMPHOCYTES -- Immunobiology of B Lymphocytes -- Regulation of B Lymphocyte Responsiveness by Multiple Cytokines -- Influence of IL4 on the Induction of Immunoglobulin Secretion by BCAF-Containing Supernatant -- Early B Cells Immortalized by Epstein-Barr Virus (EBV) - A Phenotypic Study -- The Human B Cell Repertoire: Multispecificity as a Major Characteristic of Antibodies Secreted by Human EBV-Transformable Cord Blood B Cells -- Analysis of Excessive B Cell Growth in Lymph Nodes of L. major Infected Mice: The Effect of L. major Specific T-Cell Clones -- Antibody Response in vitro of Human Peripheral Blood Lymphocytes: Application of a Limiting Dilution Method -- Frequency Analysis of Functional Immunoglobulin CE Gene Expression in LPS-Reactive Murine B Cells -- Changes in Gene Expression in Differentiating B Lymphocytes -- Regulation of Lipopolysaccharide (LPS)-Induced B Cell Differentiation by Ly-5 and Uyb-2 Molecules -- WORKSHOP I. LIPIDIC MEDIATORS OF THE IMMUNE RESPONSE -- Phospholipid-Derived Mediators and the Immune Response -- Anti-Oxidants and IL2 Synthesis -- Role of Lipoxygenase Pathway Products in IL2 Synthesis -- Platelet Activating Factor (PAF) Induces Human Suppressor Cell Activity -- PAF-Acether Induces an Enhanced Release of Interleukin-1 (IL-1) from Human Monocytes -- Down-Regulation of CD2 and CD3 Antigen Expression by PAF-Acether -- WORKSHOP J. NEURAL MODULATION OF IMMUNITY -- Neuroendocrine Modulation of Immunity -- Cyclic AMP Response to Dopamine in the Human Monocyte-Like Cell Line U-937 -- ß-Endorphin Inhibits Thy-1 Antigen Expression on Murine Thymocytes and Antagonizes Thymosin Fraction V Action -- WORKSHOP K. BIOCHEMISTRY OF LEUCOCYTE STIMULATION AND EFFECTOR MECHANISMS -- Genes Preferentially Expressed in Cytolytic T Cells -- Signal Transduction in Lymphocyte Activation -- IL-2 Mediated Induction of Lytic Granules, Perforin, and BLT-Esterase in Potent, Granule-Free Cytolytic T Lymphocytes Indicates an Alternative Function of Lytic Granules -- Extracel1ular ATP Initiates the Proliferative Response of PMA-Activated Medullary Thymocytes by Increasing their Cytosolic Free Calcium Concentration -- Evidence for a Kinase Cascade Stimulated by Interleukin 2 in Cytotoxic T Cell Clones -- The Regulation of Cytoskeletal Protein Gene Expression in Lymphocytes -- Protein Phosphorylation During T Cell Activation -- Clues to Mechanisms of Activation for Killing from the Observations of Changes in Intracellular (Ca++) in Individual Cytolytic T Cells and Targets -- Induction of Activation Signals in Human T Lymphocytes -- Both Lyt2+ and L3T4+ Cell Subsets Secrete the Serine Esterase Granzyme A in Response to a Specific Antigenic Stimulus -- WORKSHOP L. ACCESSORY CELLS-LYMPHOCYTE INTERACTIONS -- Accessory Cells-Lymphocyte Interactions -- A Role for HLA-Class I Molecules from Accessory Cells in T-Cell Activation -- Adhesion Molecules of Monocytes -- Cellular and Molecular Basis of Self-Induced Proliferation of T Lymphocytes (SIPofT) -- Human T Cell Activation: Participation of T Cell Differentiation Antigen Cluster 2 (CD2) in the Generation and/or Transduction of Accessory Cell Signals -- WORKSHOP PI. IDIOTYPIC REGULATION -- The Influence of Vk Gene Polymorphism on the Induction of Silent Idiotypes in the Arsonate System -- Allogeneic Manipulation of the "GAT" Idiotypic Cascade does not Influence the VH Gene Usage -- Specific Suppression of the Primary Antibody Response with Immune Complexes Formed in Antibody Excess Depends on the Idiotype and the Isotype of the Antibody Forming the Complex -- The HLA-Restricted Presentation of Idiotype to Human Anti-Idiotypic T Cell Clones does not Require Processing by Antigen Presenting Cells -- Idiotypic Predominance Alteration in Anti-Arsonate Response by Priming with Anti-Idiotypic Antibodies -- Anti-Idiotype Induction of Humoral Immunity in Cattle -- Anti MHC-Receptor Cytotoxic T Lymphocytes: Their Role in the Specific Resistance to Graft-Versus-Host Reaction -- Altered Anti-Idiotype Response to a(1-3)Dextran-Associated Idiotypes in Mice Bearing an X-Linked Immune Defect -- WORKSHOP N. COMPLEMENT RECEPTORS -- Human CD3 Complement Receptors -- Influence of Antigen-Bound Complement Components C3b and C4b in Activation of Human T-Cell Clones -- Human C3 and C3dg Stimulate Proliferation of a Pre-B Lymphoblastoid Cell Line via CR2 Complement Receptor -- Activation of B Lymphocytes by Zymosan-Bound C3 Fragments -- Contribution of C3 Fragments to Lymphocyte Mediated Lysis of CR2 Carrying Cells -- "In vivo" and "in vitro" Modulation of CR1 (C3b Receptor) Expression by its Ligand C3b -- WORKSHOP O. MAJOR HISTOCOMPATIBILITY COMPLEX -- MHC in Leucocyte Biology -- HLA Class I α1, α2, and ß2-Microglobulin Domain Interactions -- Diversity and Function of Human Class II MHC Antigens -- DRα-DQß Mismatched Isotype Pairing Occurs in EBV Transformed B Cell Lines -- Distinct Epitopes for Kd-Restricted Cytolytic T Cells Specific for HLA-CW3 or HLA-A24 Map to the same Region of HLA -- Resistance or Susceptibility of Human Target Cells to NK Lysis: Correlation with the Surface Expression of HLA Class I Molecules and Induction of Susceptibility by Monoclonal Anti Class I Antibodies -- WORKSHOP P (SANOFI). CLINICAL APPLICATIONS OF ANTILEUCOCYTE MONOCLONAL ANTIBODIES -- Anti-Leucocyte Monoclonal Antibodies: From Laboratory Reagents to Therapeutic Agents -- Treatment of Donor Bone Marrow with FabT101 Ricin A-Chain Immunotoxin for the Prevention of Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation -- Monoclonal Antibodies for Bone Marrow Purging before Transplantation: A Brief Review -- Comparative Efficiency of an Immunomagnetic Purging Procedure and a Rabbit Complement Lysis to Eliminate BL Cells from the Bone Marrow -- In vivo Antigenic Modulation of CD5+ Cells in Renal Transplanted Patients Receiving Anti-CD5 Antibody Infusions -- In vivo Therapy by CD8 Monoclonal Antibody for Delays to Hematological Recovery after Autologous Bone Marrow Transplantation -- Autologous Bone Marrow Transplantation for Acute Lymphoblastic Leukemia in Remission. In vitro Purging of Inoculum with Monoclonal Antibodies and Complement -- Immunosuppression by Murine Monoclonal Antibodies: The Rhesus Monkey Used for Preclinical Testing -- Therapeutic Applications of Monoclonal Antibodies for Lymphoma and Leukemia -- BMA 031 - The TCR Specific Monoclonal Antibody for Clinical Applications -- Immunoassays for the Monitoring of Kidney Graft's Transplanted Patients under 33B3.1 MOAB Therapy -- Prospective Randomized Studies of T Cell Depletion in HLA Matched Bone Marrow Transplantation (BMT) for Leukemia: 2 Studies of the GEGMO in 92 Patients -- A Monoclonal Anti Interleukin 2 Receptor Prevents Human Kidney Graft Rejection -- Clinical Pharmacology of 0KT3 -- Introduction to the Clinical Use of Monoclonal Antibodies as Immunosuppressive Agents -- General Considerations on the Quality Control of Monoclonal Antibodies before Therapeutic Use in Man -- Immunotoxins with Therapeutic Use in Man -- AUTHOR INDEX -- SUBJECT INDEX -- Backmatter