Protein-Ligand Interactions : : Proceedings of the Symposium held at the University of Konstanz, Germany, September 1974 / / hrsg. von Gideon Blauer, Horst Sund.

• Superior document: Title is part of eBook package: De Gruyter DGBA Medicine and Life Sciences - <1990
• MitwirkendeR: Antonini, Eraldo,; Barkley, Mary D.,; Beyreuther, K.,; Blauer, G.,; Bode, J.,; Bourgeois, Suzanne,; Brunori, M.,; Brunori, Maurizio,; Buehner, Manfred,; Changeux, J.P.,; Chiancone, Emilia,; Cohen, J.B.,; Colosimo, A.,; Colosimo, Alfredo,; Coulondre, C.,; Deutsch, J.,; Dieter, H.,; Fanelli, M. Rosaria Rossi,; Fanning, T.,; Files, J. G.,; Flossdorf, J.,; Frère, Jean-Marie,; Ganem, D.,; Geisler, N.,; Gho, D.,; Ghuysen, Jean-Marie,; Gilbert, Walter,; Goody, R. S.,; Gordon, A.,; Gralla, Jay,; Gross, Carol A.,; Helmreich, Ernst J. M.,; Hill, B. Müller,; Hippel, Peter H. von,; Hucho, F.,; Jobe, Alan,; Kania, J.,; Karlin, Arthur,; Kathmann, P.,; Kirschner, Kasper,; Koberstein, R.,; Kula, M.-R.,; Kushnir, Tamar,; Lavie, E.,; Lu, P.,; Lutz, R.A,; Majors, John,; Mannherz, H. G.,; Mansouri, A.,; Maxam, Allan,; McNamee, Mark G.,; Meissner, H.,; Michaelson, D.,; Miller, J. H.,; Moody, T.,; Navon, Gil,; Nieto, Manuel,; Pecht, I.,; Perkins, Harold R.,; Pfeuffer, Thomas,; Piatt, T.,; Pohl, Fritz M.,; Popot, J.L.,; Prätorius, H.-J.,; Raftery, M.A.,; Revzin, Arnold,; Ross, M.J.,; Sadler, John R.,; Schlotmann, M.,; Schmeissner, U.,; Schmitz, A.,; Steinhardt, Jacinto,; Stroud, R.M.,; Sugiyama, H.,; Sund, H.,; Triesch, I.,; Vandlen, R.,; Wang, Amy C.,; Wang, James C.,; Weber, Gregorio,; Weber, K.,; Weber, M.,; Weder, H. G.,; Weill, Cheryl L.,; Weischet, Wolfgang,; Wiegand, U.-W.,; Winterhalter, K. H.,; Wiskocil, Robert L.,; Woody, Robert W.,; Wyman, J.,; Wyman, Jeffries,; Yonath, J.,; lorio, E. E. Di,
• HerausgeberIn: Blauer, Gideon,; Sund, Horst,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2019]; ©1975
• Year of Publication: 2019
• Edition: Reprint 2019
• Language: German
• Physical Description: 1 online resource (486 p.) :; Num. figs.

Table of Contents

• Frontmatter
• Preface
• Section I. General
• Letter from J. Wyman to the Members of the Symposium
• Concerted Changes in an Allosteric Macromolecule
• Ligand Interactions in Globular Proteins
• Discussion
• Ligand Binding to Enzyme Complexes
• Discussion
• Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography
• Discussion
• Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes
• Discussion
• Section II. Enzymes
• The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis
• Discussion
• The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog
• Discussion
• The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin
• Discussion
• Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes
• Discussion
• On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600
• Discussion
• The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity
• Discussion
• Cooperative Interactions without Symmetry or Subunits
• Discussion
• A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A
• Discussion
• Section III. Repressors
• Lactose Operator Sequences and the Action of Lac Repressor
• Discussion
• The Active Sites of Lac Repressor
• Discussion
• Lac Repressor
• Discussion
• The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules
• Discussion
• Effect of Alterations in Lac Operator DNA on Repressor Binding
• Discussion
• Interaction of Lac Repressor with Non-Specific DNA Binding Sites
• Discussion
• Section IV. Receptors
• Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata
• Discussion
• Subunit Structure and Binding Sites of the Acetylcholine Receptor
• Discussion
• Further Characterization of Purified Acetylcholine Receptor and its Incorporation into Phospholipid Vesicles
• Discussion
• Structural and Functional Studies of an Acetylcholine Receptor
• Discussion
• Section V. Antibodies, Drugs and Metabolites
• Antibody Combining Sites as a Model for Molecular Recognition
• Discussion
• Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis
• Discussion
• Problems in Studying Protein Binding with Regard to the Interaction of Steroids with a Specific Binding Globulin
• Discussion
• The Interaction of Low-Molecular Compounds with Serum Albumin as Measured by Optical Methods. Circular Dichroism of Bilirubin-Human Serum Albumin Complexes in the Presence of Alcohols in Aqueous Solution
• Discussion
• Section VI. Detergents and Electrolytes
• The Nature of Specific and Non-Specific Interactions of Detergents with Proteins: Complexing and Unfolding
• Discussion
• Interaction of Detergents with Proteins: Effect of Counter Ions on the System Ferrimyoglobin- Laurylpyridinium Halides in Aqueous Medium
• Discussion
• Influence of Ions on the Kinetics of Cooperative Conformational Changes in Globular Proteins
• Discussion
• Neutral Salt Effects on the Conformational Stability of Biological Macromolecules
• Discussion
• Concluding Remarks
• Index of Contributors
• Subject Index
• Backmatter