Protein-Ligand Interactions : : Proceedings of the Symposium held at the University of Konstanz, Germany, September 1974 / / hrsg. von Gideon Blauer, Horst Sund.
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Other title: | Frontmatter -- Preface -- Section I. General -- Letter from J. Wyman to the Members of the Symposium -- Concerted Changes in an Allosteric Macromolecule -- Ligand Interactions in Globular Proteins -- Discussion -- Ligand Binding to Enzyme Complexes -- Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography -- Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes -- Section II. Enzymes -- The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis -- The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog -- The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin -- Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes -- On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600 -- The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity -- Cooperative Interactions without Symmetry or Subunits -- A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A -- Section III. Repressors -- Lactose Operator Sequences and the Action of Lac Repressor -- The Active Sites of Lac Repressor -- Lac Repressor -- The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules -- Effect of Alterations in Lac Operator DNA on Repressor Binding -- Interaction of Lac Repressor with Non-Specific DNA Binding Sites -- Section IV. Receptors -- Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata -- Subunit Structure and Binding Sites of the Acetylcholine Receptor -- Further Characterization of Purified Acetylcholine Receptor and its Incorporation into Phospholipid Vesicles -- Structural and Functional Studies of an Acetylcholine Receptor -- Section V. Antibodies, Drugs and Metabolites -- Antibody Combining Sites as a Model for Molecular Recognition -- Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis -- Problems in Studying Protein Binding with Regard to the Interaction of Steroids with a Specific Binding Globulin -- The Interaction of Low-Molecular Compounds with Serum Albumin as Measured by Optical Methods. Circular Dichroism of Bilirubin-Human Serum Albumin Complexes in the Presence of Alcohols in Aqueous Solution -- Section VI. Detergents and Electrolytes -- The Nature of Specific and Non-Specific Interactions of Detergents with Proteins: Complexing and Unfolding -- Interaction of Detergents with Proteins: Effect of Counter Ions on the System Ferrimyoglobin- Laurylpyridinium Halides in Aqueous Medium -- Influence of Ions on the Kinetics of Cooperative Conformational Changes in Globular Proteins -- Neutral Salt Effects on the Conformational Stability of Biological Macromolecules -- Concluding Remarks -- Index of Contributors -- Subject Index -- Backmatter |
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Format: | Mode of access: Internet via World Wide Web. |
ISBN: | 9783110830811 9783110637861 |
DOI: | 10.1515/9783110830811 |
Access: | restricted access |
Hierarchical level: | Monograph |
Statement of Responsibility: | hrsg. von Gideon Blauer, Horst Sund. |
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