Concepts in Gene Therapy / / ed. by John A. Barranger, Michael Strauss.

• Superior document: Title is part of eBook package: De Gruyter DGBA Physical Sciences 1990 - 1999
• MitwirkendeR: Bahnson, Alfred,; Ball, Edward,; Barranger, John A.,; Baum, Christopher,; Beeler, Margeret,; Blankenstein, Thomas,; Bohl, Delphine,; Bohnlein, Ernst,; Brand, Karsten,; Cayeux, Sophie,; Cichon, Gunter,; Coutelle, Charles,; Culver, Kenneth W.,; Dedieu, Jean-François,; Dickson, George,; Dorken, Bernd,; Dunigan, James,; Eckert, Hans-Georg,; Eckstein, Fritz,; Evans, Christopher H.,; Fink, D. J.,; Ghivizzani, Steven C.,; Ginzberg, Dalia,; Glorioso, J. C.,; Goins, W. F.,; Gotthardt, Michael,; Grifman, Mirta,; Gunzburg, Walter H.,; Heard, Michel,; Heidenreich, Olaf,; Herz, Joachim,; Kang, Richard,; Kemp, Amy,; Krisky, D.,; Lancia, Jason,; Learish, Randall,; Lev-Lehman, Efrat,; Liu, Chunming,; Mannion-Henderson, Jane,; Marconi, P.,; McCarty, D. M.,; Mierski, Joseph,; Milich, Lynn,; Mohney, Trina,; Nimgaonkar, Maya,; Oligino, T.,; Orsini, Cécile,; Ostertag, Wolfram,; Perricaudet, Michel,; Poliani, P. L.,; Rakhmilevich, Alexander L.,; Ramakrishnan, R.,; Rice, Erin,; Robbins, Paul D.,; Salmons, Brian,; Samulski, R. J.,; Sandig, Volker,; Schmidt, Walter,; Schuster, Herbert,; Soreq, Hermona,; Stocking, Carol,; Strauss, Michael,; Sullenger, Bruce A.,; Vallor, Michael J.,; Vigne, Emmanuelle,; Wagener, Thomas,; Watkins, Simon,; Willnow, Thomas E.,; Wu, Catherine H.,; Wu, George Y.,; Yang, Ning-Sun,; Yeh, Patrice,; Zakut, Haim,
• HerausgeberIn: Barranger, John A.,; Strauss, Michael,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2020]; ©1997
• Year of Publication: 2020
• Edition: Reprint 2020
• Language: English
• Physical Description: 1 online resource (553 p.)

Table of Contents

• Frontmatter
• Preface
• Contents
• I. Methods of Gene Delivery
• 1. Retroviral Vectors
• 2. Adenoviral Vectors
• 3. Herpes Simplex Virus Mediated Gene Transfer to Neurons
• 4. Adeno-Associated Viral Vectors
• 5. Virus Functions for Artificial Vectors
• 6. Targeted Gene Delivery and Expression in Hepatocytes
• 7. Particle-Mediated Gene Delivery System for Cancer Research
• II. Methods for Inactivation or Restoration of Gene Function
• 8. Gene Inactivation by Homologous Recombination - Animal Models of Plasma Lipoprotein Disorders
• 9. Potential Antisense Oligonucleotide Therapies for Neurodegenerative Diseases
• 10. Synthetic Ribozymes: The Hammerhead Ribozyme
• 11. Ribozymes as Tools for the Gene Therapist
• III. Cellular Target Systems
• 12. Gene Transfer and Transgene Expression in Hematopoietic Cells
• 13. The Liver as a Target for Gene Therapy
• 14. Gene Therapy for Gaucher Disease via Genetically Engineered Primary Myoblasts
• 15. In vivo Secretion of Therapeutic Proteins from Neo-Organs
• IV. Genetic Diseases
• 16. Gene Therapy for Cystic Fibrosis - Strategies, Problems and Perspectives
• 17. Gene Therapy for Dystrophin Deficiency
• 18. Gene Therapy For Familial Hypercholesterolemia
• 19. Therapeutic Strategies for the Lysosomal Storage Disorders
• V. Non-Genetic and Infectious Diseases
• 20. Gene Therapy for Arthritis
• 21. Gene Therapy for HIV-1 Disease
• VI. Cancer
• 22. Suicide Genes for the Treatment of Cancer
• 23. Tumor Cell Vaccines Using Genetically Modified Cells Coexpressing Cytokines and the T Cell Costimulatory Molecule B7
• 24. Dosage Impact on Immunotherapy with Cytokine-Gene Modified Cancer Vaccines
• 25. Tumor Suppressor Gene Therapy - Growth Arrest and Programmed Cell Death
• Acknowledgement
• References
• Contributors
• Index