Solubility in Pharmaceutical Chemistry / / ed. by Christoph Saal, Anita Nair.

• Superior document: Title is part of eBook package: De Gruyter DG Ebook Package English 2020
• MitwirkendeR: Bauer-Brandl, Annette,; Beckmann, Wolfgang,; Berghausen, Joerg,; Brandl, Martin,; Desrayaud, Sandrine,; Dodd, Stephanie,; Dressman, Jennifer,; Elder, David,; Faller, Bernard,; Holm, René,; Laisney, Marc,; McDonagh, James L.,; Mitchell, John Bo,; Palmer, David S,; Reppas, Christos,; Saal, Christoph,; Skyner, Rachael E.,; Valko, Klara,; Vertzoni, Maria,
• HerausgeberIn: Nair, Anita,; Saal, Christoph,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2020]; ©2020
• Year of Publication: 2020
• Language: English
• Physical Description: 1 online resource (VIII, 362 p.)
• Other title: Frontmatter --; Contents --; List of contributors --; 1. Solubility – definition and basic physicochemical considerations --; 2. Solubility and supersaturation --; 3. In Silico methods to predict solubility --; 4. How solubility influences bioavailability --; 5. Estimation of intraluminal drug solubility --; 6. Biorelevant media --; 7. The role of solubility to optimize drug substances – a medicinal chemistry perspective --; 8. The role of solubility in optimizing drug products – a pharmaceutical development perspective --; 9. The relevance of solid-state forms for solubility --; 10. Solubility and phase behaviour from a drug substance manufacturing perspective --; 11. Biowaivers --; List of Abbreviations --; Index
• Format: Mode of access: Internet via World Wide Web.
• ISBN: 9783110559835; 9783110696288; 9783110696271; 9783110659061; 9783110616859; 9783110704716; 9783110704518; 9783110704754; 9783110704556
• DOI: 10.1515/9783110559835
• Access: restricted access
• Hierarchical level: Monograph
• Statement of Responsibility: ed. by Christoph Saal, Anita Nair.

This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.