Protein Tyrosine Phosphatases : : Structure, Signaling and Drug Discovery / / Lalima G. Ahuja.
Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of sign...
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Ahuja, Lalima G., author. aut http://id.loc.gov/vocabulary/relators/aut Protein Tyrosine Phosphatases : Structure, Signaling and Drug Discovery / Lalima G. Ahuja. Berlin ; Boston : De Gruyter, [2018] ©2018 1 online resource (XIV, 282 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Frontmatter -- Preface -- About The Author -- Contents -- 1.Tyrosine Phosphorylation In Cell Signaling: Discovery And Beyond -- 2.Protein Phosphatases: Classification And Domain Architecture -- 3.Protein Tyrosine Phosphatases: Molecular Structure And Mechanism -- 4.The Receptor Protein Tyrosine Phosphatases: Structure And Function -- 5.The Double-Domain Receptor Protein Tyrosine Phosphatases -- 6 The Non-Receptor Protein Tyrosine Phosphatases: Part I -- 7.The Non-Receptor Protein Tyrosine Phosphatases: Part Ii -- 8.Protein Tyrosine Phosphatases: Strategies For Drug Development -- Index restricted access http://purl.org/coar/access_right/c_16ec online access with authorization star Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes. Mode of access: Internet via World Wide Web. In English. Description based on online resource; title from PDF title page (publisher's Web site, viewed 30. Aug 2021) Protein-tyrosine phosphatase. Biochemie. Medizinische Chemie. Proteintyrosinphosphatase. Signalproteine. Wirkstoffdesign. SCIENCE / Chemistry / Clinical. bisacsh Biochemistry. Drug Design. Medicinal Chemistry. Protein Tyrosine Phosphatase. Signalling Proteins. Title is part of eBook package: De Gruyter DG Plus eBook-Package 2018 9783110719550 Title is part of eBook package: De Gruyter EBOOK PACKAGE COMPLETE 2018 English 9783110604252 Title is part of eBook package: De Gruyter EBOOK PACKAGE COMPLETE 2018 9783110603255 ZDB-23-DGG Title is part of eBook package: De Gruyter EBOOK PACKAGE Physics, Chem., Mat.Sc, Geosc 2018 English 9783110604221 Title is part of eBook package: De Gruyter EBOOK PACKAGE Physics, Chemistry, Materials Sc, Geosc 2018 9783110603224 ZDB-23-DPC EPUB 9783110421842 print 9783110426434 https://doi.org/10.1515/9783110421774 https://www.degruyter.com/isbn/9783110421774 Cover https://www.degruyter.com/cover/covers/9783110421774.jpg |
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Ahuja, Lalima G., Ahuja, Lalima G., |
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Ahuja, Lalima G., Ahuja, Lalima G., Protein Tyrosine Phosphatases : Structure, Signaling and Drug Discovery / Frontmatter -- Preface -- About The Author -- Contents -- 1.Tyrosine Phosphorylation In Cell Signaling: Discovery And Beyond -- 2.Protein Phosphatases: Classification And Domain Architecture -- 3.Protein Tyrosine Phosphatases: Molecular Structure And Mechanism -- 4.The Receptor Protein Tyrosine Phosphatases: Structure And Function -- 5.The Double-Domain Receptor Protein Tyrosine Phosphatases -- 6 The Non-Receptor Protein Tyrosine Phosphatases: Part I -- 7.The Non-Receptor Protein Tyrosine Phosphatases: Part Ii -- 8.Protein Tyrosine Phosphatases: Strategies For Drug Development -- Index |
author_facet |
Ahuja, Lalima G., Ahuja, Lalima G., |
author_variant |
l g a lg lga l g a lg lga |
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VerfasserIn VerfasserIn |
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Ahuja, Lalima G., |
title |
Protein Tyrosine Phosphatases : Structure, Signaling and Drug Discovery / |
title_sub |
Structure, Signaling and Drug Discovery / |
title_full |
Protein Tyrosine Phosphatases : Structure, Signaling and Drug Discovery / Lalima G. Ahuja. |
title_fullStr |
Protein Tyrosine Phosphatases : Structure, Signaling and Drug Discovery / Lalima G. Ahuja. |
title_full_unstemmed |
Protein Tyrosine Phosphatases : Structure, Signaling and Drug Discovery / Lalima G. Ahuja. |
title_auth |
Protein Tyrosine Phosphatases : Structure, Signaling and Drug Discovery / |
title_alt |
Frontmatter -- Preface -- About The Author -- Contents -- 1.Tyrosine Phosphorylation In Cell Signaling: Discovery And Beyond -- 2.Protein Phosphatases: Classification And Domain Architecture -- 3.Protein Tyrosine Phosphatases: Molecular Structure And Mechanism -- 4.The Receptor Protein Tyrosine Phosphatases: Structure And Function -- 5.The Double-Domain Receptor Protein Tyrosine Phosphatases -- 6 The Non-Receptor Protein Tyrosine Phosphatases: Part I -- 7.The Non-Receptor Protein Tyrosine Phosphatases: Part Ii -- 8.Protein Tyrosine Phosphatases: Strategies For Drug Development -- Index |
title_new |
Protein Tyrosine Phosphatases : |
title_sort |
protein tyrosine phosphatases : structure, signaling and drug discovery / |
publisher |
De Gruyter, |
publishDate |
2018 |
physical |
1 online resource (XIV, 282 p.) |
contents |
Frontmatter -- Preface -- About The Author -- Contents -- 1.Tyrosine Phosphorylation In Cell Signaling: Discovery And Beyond -- 2.Protein Phosphatases: Classification And Domain Architecture -- 3.Protein Tyrosine Phosphatases: Molecular Structure And Mechanism -- 4.The Receptor Protein Tyrosine Phosphatases: Structure And Function -- 5.The Double-Domain Receptor Protein Tyrosine Phosphatases -- 6 The Non-Receptor Protein Tyrosine Phosphatases: Part I -- 7.The Non-Receptor Protein Tyrosine Phosphatases: Part Ii -- 8.Protein Tyrosine Phosphatases: Strategies For Drug Development -- Index |
isbn |
9783110421774 9783110719550 9783110604252 9783110603255 9783110604221 9783110603224 9783110421842 9783110426434 |
callnumber-first |
Q - Science |
callnumber-subject |
QP - Physiology |
callnumber-label |
QP609 |
callnumber-sort |
QP 3609 P56 A44 42018 |
url |
https://doi.org/10.1515/9783110421774 https://www.degruyter.com/isbn/9783110421774 https://www.degruyter.com/cover/covers/9783110421774.jpg |
illustrated |
Not Illustrated |
dewey-hundreds |
500 - Science |
dewey-tens |
570 - Life sciences; biology |
dewey-ones |
572 - Biochemistry |
dewey-full |
572/.68 |
dewey-sort |
3572 268 |
dewey-raw |
572/.68 |
dewey-search |
572/.68 |
doi_str_mv |
10.1515/9783110421774 |
oclc_num |
1059280908 |
work_keys_str_mv |
AT ahujalalimag proteintyrosinephosphatasesstructuresignalinganddrugdiscovery |
status_str |
n |
ids_txt_mv |
(DE-B1597)451312 (OCoLC)1059280908 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Title is part of eBook package: De Gruyter DG Plus eBook-Package 2018 Title is part of eBook package: De Gruyter EBOOK PACKAGE COMPLETE 2018 English Title is part of eBook package: De Gruyter EBOOK PACKAGE COMPLETE 2018 Title is part of eBook package: De Gruyter EBOOK PACKAGE Physics, Chem., Mat.Sc, Geosc 2018 English Title is part of eBook package: De Gruyter EBOOK PACKAGE Physics, Chemistry, Materials Sc, Geosc 2018 |
is_hierarchy_title |
Protein Tyrosine Phosphatases : Structure, Signaling and Drug Discovery / |
container_title |
Title is part of eBook package: De Gruyter DG Plus eBook-Package 2018 |
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1806144391571570688 |
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